Sentences with phrase «of cellular gene»

Because the pathophysiology of cancer is linked to alteration of cellular gene expression, the bioinformatics toolbox promises to offer countless molecular insights into mechanisms, diagnostics, and new medical interventions for cancer.

To account for the remarkable similarity between retrovirus oncogenes and their normal cellular kin, most virologists have settled on the idea that retrovirus oncogenes are copies of cellular genes.

«In contrast to RNA interference, which is commonly used to inactivate gene activity, the CRISPR - on system allows activation of cellular genes.

Not exact matches

Experiments proved that Heat Shock Factor 1 (HSF1), a sort of protective switch against some types of cellular stress, could bind to the TTR gene's promoter (a segment of DNA near the TTR gene).

The disruption of prenatal cellular activity in zebra fish, which share 80 percent of their genes with humans and are considered a good model for studying human brain development, seemed to result in hyperactivity, according to the Canadian study, which was published Monday in the Proceedings of the National Academy of Sciences.

A host of other genes, which control many other cellular processes do not show such abnormal DNA methylation after smoke exposure.

Scientists hacked the machinery of cellular warfare to splice genes.

The boosted genes had three main effects: improving cellular energy efficiency; upping insulin production, which improves control of blood sugar; and preventing the breakdown of caps on chromosomes that help prevent cells wearing out and ageing.

Sequence analysis of the virus revealed numerous genes previously thought to exist only in cellular organisms.

The gene signature identified by Hancock and his colleagues relates to a special type of immune suppression called cellular reprogramming and suggests that treating inflammation in sepsis is a bad idea.

Mothers Against Decapentaplegic: This gene helps control the biochemical translation of cellular messages.

Like all retroviruses, HIV has very few genes of its own and must take over the host's cellular machinery in order to propagate and spread throughout the body.

Gene Yeo, a professor of cellular and molecular medicine at UCSD, led the research and showed he could target RNA in living cells, a first step toward treating diseases like muscular dystrophy and neurodegeneration.

This enabled the researchers to detect mutations in three genes — GNPTAB, GNPTG, and NAGPA — involved in the function of lysosomes, the cellular sacs where debris gets recycled.

Some of those matching genes are vital for embryo survival, including several responsible for cell communication, cellular energy and adhesion to the lining of the uterus.

In humans, stuttering has long been linked to a mutation in the «housekeeping» gene Gnptab, which maintains basic levels of cellular function.

The pilot project tested a dozen or so of the most commonly used gene promoters (regions of DNA that facilitate gene transcription) and segments of DNA that encode ribosome - binding sites (sequences of messenger RNA that control protein translation) to determine whether they behave consistently in different cellular contexts.

To do this, they created a cellular model of Werner syndrome by using a cutting - edge gene - editing technology to delete WRN gene in human stem cells.

Although there are several ways to remove RB from the cellular machinery, the group found that complete loss, rather than inactivation, of the RB gene was associated with changes in gene - networks closely linked to aggressive disease.

Researchers did not understand what normally kept ras genes» protein production in check — and why certain ras mutations led to such chaotic, uncontrolled cellular activity — until the discovery of a snippet of genetic material called microRNA (miRNA).

When researchers suppressed the ARF gene in mole - rat cells during the reprogramming process to iPSCs, the cells stopped proliferation with sign of cellular senescence, while the opposite happens with mouse cells.

This so - called microRNA disrupts the expression of two key cellular genes called TGF - β and SMAD3, in a process known as RNA interference (RNAi).

A forward genetic screen in Drosophila melanogaster (fruit flies) identified mutant copies, or alleles, of a gene called cacophony associated with defects in autophagy and cellular homeostasis.

The gene Apc is like a club bouncer: It keeps cellular parties from growing out of control.

Kolodner describes the mismatch repair genes as performing the «cellular equivalent of a spellchecking function».

The researchers developed a computational framework to determine the structure of protein interaction networks in each sample and infer which genes performed different cellular functions within these networks.

They found many of the 131 regions were related to genes involved in growth and development and cellular function and maintenance.

Analysis of the tumor genes affected by the two drugs revealed that cabazitaxel had a greater effect on cellular division and regulation of chromatin — a spool for DNA that helps control which genes are in use and when — whereas docetaxel has a greater impact on DNA transcription and repair.

As scientists began to sequence human genes in the 1990s, sorting out the cellular locations of each gene's proteins became a priority, says Mathias Uhlén, a microbiologist at the Royal Institute of Technology in Stockholm, Sweden, and director of the Protein Atlas effort.

In particular, this region of the gene might serve as a landing place for cellular machinery that binds to the DNA and reads it, Nikolova said.

They found a mechanism explaining how, in the case of pathological cardiac hypertrophy, cardiomyocytes lose their adult cellular state and regress back towards their fetal form, switching on genes that were originally expressed as the heart develops in the embryo and usually permanently switched off after birth.

Scientists of Helmholtz Zentrum München and Ludwig - Maximilians - Universität Munich (LMU) have discovered that two new classes of histone modifications couple cellular metabolism to gene activity.

Optogenetic methods and tools have evolved fast, and in addition to be able to control cellular activity, researchers can now control the activity of gene function.

Named after the IBM Blue Gene supercomputer it relies on, the Blue Brain Project has started modelling — in every detail — the cellular infrastructure and electrophysiological interactions within the cerebral neocortex, which represents about 80 % of the brain and is believed to house cognitive functions such as language and conscious thought.

The cellular functions that Finch studied for his «second Ph.D.» included the activation of the gene that encodes tyrosine aminotransferase (TAT).

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

Yamanaka's group and two others followed up earlier this year with firmer evidence that these induced pluripotent stem (iPS) cells faithfully mimicked the patterns of gene activity and cellular differentiation observed in embryonic stem cells.

«Calcium signaling regulates many important cellular functions, like muscle contraction, neural communication, gene transcription and tissue growth,» said Fenfang Li, a postdoctoral research fellow in Zhong's laboratory and lead author of the study.

While her postdoc work is not related directly to cystinosis, she hopes there are aspects of the gene therapy and cellular therapy skills she is learning at Scripps that will be transferable to her work with the disease.

Understanding the best ways to work with RNA and the various RNA detection methods can help scientists advance our understanding of gene expression patterns and elucidate the roles of different genomic elements in cellular function and dysfunction.

A «perfect storm» leads to the collapse of almost all the molecular functions of SRY, including cellular trafficking, stability, DNA recognition and gene regulation.»

Scientists led by John Kuwada, professor of molecular, cellular and developmental biology at the University of Michigan, and Hiromi Hirata of the National Institute of Genetics in Japan originally identified the gene in mutant zebrafish that exhibited severe muscle weakness.

And many of the highlighted human genes are associated with the same critical cellular operations, such as the cell's protein - building factories, as in those species, MacArthur's group reports.

The gene plays a key role in cellular proliferation and is activated in 90 % of all human pancreatic tumors.

The analysis also showed that the preponderance of host responses shifted rapidly from activation of genes involved in cell damage and inflammation toward those linked to promotion of cellular and organ repair.

A total of 1738 predicted protein - coding genes were identified; however, only a minority of these (38 percent) could be assigned a putative cellular role with high confidence.

By comparing the gene expression patterns of normal beta cells and insulin - producing cells derived from alpha cells, the researchers confirmed nearly complete cellular reprogramming.

At the cellular level, although they share canonical types of inhibitory interneurons (INs) and excitatory principal neurons (PNs), it remains largely unknown to what extent a single type in different brain regions displays similarity in gene expression, axonal shape, connectivity, and developmental origins.

With just 121 protein - coding genes, the diminutive Tremblaya princeps, a symbiotic bacterium that lives inside specialized cells of the sap - eating mealybug, has the smallest known genome of any cellular organism on the planet.

The goal of the NIH program, as described on its website, is «to understand the principles behind the three - dimensional organization of the nucleus in space and time (the fourth dimension), the role nuclear organization plays in gene expression and cellular function, and how changes in the nuclear organization affect normal development as well as various diseases.»