Her laboratory studies the impact
of cellular metabolism on the epigenome, focusing on the role of acetyl - CoA in regulating histone acetylation.
Measuring the variations in the intensity of the resulting fluorescence provides a «dynamic
readout of cellular metabolism» which is a sensitive biomarker of drug response.
We will seek investigators that span a range of metabolism expertise, with an emphasis on interdisciplinary and collaborative - minded researchers passionate about exploring the basic molecular and mechanistic
underpinnings of cellular metabolism and its dysfunction in human disease.
Many of the clinical signs associated with canine hypothyroidism are directly related to
slowing of cellular metabolism, which results in development of mental dullness, lethargy, exercise intolerance, and weight gain without a corresponding increase in appetite.
LKB1, originally identified as a tumor suppressor protein, is currently thought as a critical
regulator of cellular metabolism and growth by controlling the activity of AMP - activated protein kinase (AMPK) and also 12 other kinases that are closely related to AMPK.
According to the United States Office of Dietary Supplements — National Institutes of Health, Zinc is involved in numerous
aspects of cellular metabolism.
Brain connectivity may be studied and analyzed using a broad range of network analysis approaches, many of which are also applied in parallel efforts to map and describe other biological networks, e.g.
those of cellular metabolism, gene regulation, or ecology.