Sentences with phrase «of cellular pathways»
Many terpenes and volatile chemicals released by plants appear to reduce all of these cellular pathways, promoting less inflammation, and hopefully less diseases like cancer.
http://colinchamp.com/
Kontoyiannis D., Boulougouris G., Manoloukos M., Armaka M., Apostolaki M., Pizarro T., Kotlyarov A., Forster I., Flavell R., Gaestel M., Tsichlis P., Cominelli F., Kollias G., 2002, «Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor - induced Crohn's - like inflammatory bowel disease», JEM, 196, 1563 - 74.
The multitude of cellular pathways targeted by anthelminthics is difficult to explain.
«The mineral zinc acts as a catalytic, structural and signaling factor in the regulation of a diverse array of cellular pathways involving hundreds of enzymes and proteins,» he said.
Small molecule drugs were used to inhibit the function of a cellular pathway associated with protein synthesis.
Using these orthogonal measures of cellular pathway analysis, we confirmed that HPP - 4382, in contrast to bardoxolone, did not induce significant cellular stress at high doses as measured by HSPA6 expression and that the mechanism of HPP - 4382 activity does not appear dependent on NF - B as ICAM1 expression is not induced by HPP - 4382 (data not shown).
Not exact matches
Intermittent fasting, regular exercise and consumption of dietary phytochemicals can have a major positive impact on health by bolster - ing adaptive cellular stress response pathways that protect against and counteract a range of major diseases.
The probablility of all the cellular machinery (enzymes, ion channels, RNA polymerase, anabolic and catabolic pathways, etc) just assembling out of randomn peptides and nucleic acids is infinitely small.
We are now beginning to understand some facets of human emotionality, decision - making, morality, trauma and the drive for political power down to the cellular level, by observing changes in neurochemistry, neural pathways, and neuro - anatomical transformations in the brain.
Once there, the protein acts on the osteoblasts and inhibits Wnt activity, which is a cellular signalling pathway that is involved in the formation of the skeleton and in certain disorders, such as osteoporosis, arthritis and myeloma.
When mutated, BRAF, an enzyme that acts in a signaling cascade known as the MAPK / ERK pathway, becomes overactive and leads to increased cellular growth, a hallmark of cancer.
«This occurs when CSN6 is deregulated through a series of cellular signaling pathways.»
Clinically important findings suggest that targeting the epidermal growth factor receptor (EGFR) and the fibroblast growth factor receptor (FGFR) cellular pathways may benefit thousands of patients with this disease, according to the study published today in the journal PLOS Genetics.
In addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researchers.
Called mTOR in mammals, for the term «mammalian target of rapamycin,» this pathway has a critical evolutionary value — it helps an organism avoid too much cellular expansion and growth when energy supplies are insufficient.
We also observed that HIV rewires cellular defensive pathways to benefit survival of the virus,» he added.
The transcription of non-coding regions in the genome is precisely regulated by cellular signaling pathways — and on a grand scale: up to 80 per cent of the RNA copies were non-coding.
«With this study, we have validated both NOX1 and NOX4 as core mediators of liver fibrosis and laid out the step - by - step cellular pathways that lead to this disease.»
«An exaggerated inflammatory response among cellular elements of the innate immune system can drive the adaptive immune system down an allergy - associated T H2 pathway,» said Vuillermin.
Through the mTOR signalling pathway, it is involved in the regulation of many cellular processes, including cell survival, metabolism, proliferation, differentiation, and senescence.
Cell lines are the workhorses of biology, routinely stocked and studied in every laboratory to understand cellular pathways, receptors, targets, hormones, and all aspects of normal and malignant physiology.
Rapamycin, which is an inhibitor of the mammalian target of rapamycin (mTOR) signaling pathway, has a variety of cellular functions and is known to possess both immunosuppressant and anti-tumor properties.
Meanwhile, cancer genome projects have yielded unprecedented insights into the cellular signaling pathways that drive the development and progression of cancer — information that has led to effective therapies tailored for individual patients.
The use of photo - clickable miRNAs may reveal more miRNA - involved cellular regulation pathways and more possible miRNA targets with pathological importance.
Ballabio and his colleagues studied the role of the pathway in two normal cellular activities; how cells respond to physical exercise and how they respond to nutrient availability.
«This new study extends those original mechanistic findings to the amyloid pathway and preservation of cellular and synaptic connections.
Scientists have discovered a new cellular pathway that can promote and support the growth of cancer cells.
Pathways involved in cellular metabolism typically regulate themselves, meaning that some components of the pathway control each other's activities.
The other study showed how using a combination of drugs at increased potency could prove an effective therapy against glioblastoma by inhibiting the PI3K and MAPK cellular pathways.
The results suggest the simultaneous activation of certain molecular pathways — actions among molecules in a cell that can lead to change — in particular the MAPK and PI3K cellular pathways, triggered tumor initiation and produced increasingly dense low - grade gliomas that quickly progressed to glioblastoma multiforme (GBM).
This study reveals how lipids control SH2 domain - mediated cellular protein interaction networks and suggests a new strategy for the therapeutic modulation of pY - signaling pathways.
«Our study provides profound insight into the role of cellular hypoxia in FOP flare - ups and shows that cellular oxygen sensing through HIF - 1α is a critical regulator of the BMP pathway and heterotopic ossification in FOP,» Kaplan said.
The team's findings suggest that the egg's special cellular vesicles represent a new type of system that is a unique combination of three separate biological processes whose pathways may have diverged from their classic functions.
«Almost nothing is known» about the molecular and cellular mechanism by which water is detected in the mouth and throat, and the neural pathway by which that signal is transmitted to the brain, says Zachary Knight, a neuroscientist at the University of California, San Francisco.
The mechanisms underlying consciousness could reside at any of a variety of physical levels: molecular, cellular, circuit, pathway, or some organizational level not yet described.
A team of researchers led by Professor Lindsay Hinck at the University of California, Santa Cruz, examined the ROBO signaling pathway in breast epithelial cells and found that one family member, ROBO1, enhances cellular contractility and stimulates assembly of cell - matrix adhesions.
The growth of pNET malignant cells is closely tied to a cellular pathway known as mTOR (mammalian target of rapamycin).
«The discovery of these new, natural grape - derived polyphenol compounds targeting cellular and molecular pathways associated with inflammation may provide an effective way to treat a subset of people with depression and anxiety, a condition that affects so many people.»
Importantly, these newly identified helper proteins channel the cellular garbage by a «self - eating» pathway (autophagy) to the lysosome, a compartment of cells dedicated for destruction and recycling.
To coordinate their size and growth with current environmental conditions, cells rely on the mechanistic target of rapamycin complex 1 (mTORC1) pathway, which senses cellular stresses, growth factors, and the availability of nutrients, such as amino acids and glucose.
Known as much for its complexity as its vital role in regulating cellular and organismal growth, the mechanistic target of rapamycin complex 1 (mTORC1) pathway has seemingly been acting in mysterious ways.
A proteomics analysis revealed expression changes of 56 proteins, and a further protein pathway analysis suggested their association with the cell morphology, the organization, and the increased cellular movement and the proliferation.
Scientists in the laboratory of Stefan Jentsch at the MPIB now successfully used baker's yeast for screening for new cellular waste disposal pathways.
My lab is investigating the normal cellular functions of signaling pathways implicated in neurological disease, with an emphasis on axon growth and guidance.
Genome editing is used in many different cell types and organisms to specifically modify genes for the interrogation of fundamental cellular pathways.
Hsieh brings expert knowledge of prostate cancer and the PI3K pathway and its effects on a critical cellular process: translating genetic material into proteins, our cells» workhorses.
His lab went on to molecularly decode a number of new components of this cellular starvation pathway, which connects nutrition and exercise to suppression of both cancer and diabetes.
Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress.
Multiple effects of a novel epothilone analog on cellular processes and signaling pathways regulated by Rac1 GTPase in the human breast cancer cells.
Moreover; the PI3K / AKT pathway also can contribute to melanoma tumorigenesis through mutations or loss in PTEN and dysregulation in expression of AKT, which positively regulates the G1 / S phase progression in cell cycle, suppresses apoptosis and promotes cellular survival.