The technology offers unprecedented
views of cellular processes and will allow researchers to observe cells in their natural state, an important step in teasing out normal and disease processes.
But even using animal cells can be a terrific way to test and research the effect of experimentation on humans:
Many of the cellular processes and functions are quite similar between organisms.
Due to the major importance of iron in a wide
variety of cellular processes, and the harm caused by its uncontrolled accumulation in the body, its uptake and storage is strictly regulated.
Thanks to these cutting - edge technologies, the researchers are able to provide homogeneous
control of a cellular process over a very long period.
«Blocking this genetic key, called P - TEFb, prevents the immune system from mobilising such an aggressive response,» explains Dr Jenner «P - TEFb is important for a
lot of cellular processes, and drives uncontrolled growth in cancer cells.
AKT is a central point in cell signaling downstream of growth factors, cytokines, and other cellular stimuli, and thus it acts as a key regulator of a wide
range of cellular processes including growth, proliferation and survival [9].
Close collaboration between the Pasteur Institute and Inria, taking the form of the InBio join research group, whose aim is to develop a methodological framework for achieving a quantitative understanding of the
functioning of cellular processes, is the perfect illustration of the value of interdisciplinary research combining experimental approaches with methodological developments.
«Our study connects the dots between Werner syndrome and heterochromatin disorganization, outlining a molecular mechanism by which a genetic mutation leads to a general
disruption of cellular processes by disrupting epigenetic regulation,» says Izpisua Belmonte.
If researchers can unlock the
secrets of this cellular process, therapies that replace diseased cells with healthy ones may one day be possible — brain - cell transplants to combat Alzheimer's, for instance, or even the creation of whole organs from scratch.
Scientists look at the structure, function, and evolution of genes (genomics), analyze the interactions with proteins these genes produce (proteomics), and systematically track the chemical
traces of cellular processes (metabolomics).
The quantitative analysis of molecule interactions in bioimaging is key for understanding the molecular
orchestration of cellular processes and is generally achieved through the study of the spatial colocalization between different populations of molecules.
This work has several important applications, including improving our understanding of the basic
biology of cellular processes, providing insights into cancer etiology and progression and identifying prognostics for cancer treatment as well as developing novel treatment strategies.
LA JOLLA — Salk Professor Tony Hunter, who holds an American Cancer Society Professorship, has been awarded $ 500,000 as part of the $ 1 million Royal Swedish Academy of Sciences» inaugural Sjöberg Prize for Cancer Research for «groundbreaking
studies of cellular processes that have led to the development of new and effective cancer drugs.»
Researchers from the Pasteur Institute and Inria, with researchers from the CNRS and Paris Diderot University, and from the Institute of Science and Technology (IST) in Austria, have published two articles in Nature Communications about computer
control of cellular processes.
Studies have established that CD47 is involved in a
range of cellular processes, including apoptosis, proliferation, adhesion and migration.
Hackermüller: «This finding gave rise to a lively discussion as to whether this could be caused by chance events or mistakes in the
regulation of cellular processes.
They also assessed the levels of gut bacteria and the «chemical fingerprints»
of cellular processes (metabolites) in their stool and urine samples.
This pathway also regulates autophagy, one
of the cellular processes that eliminates amyloid - beta.
Lead researcher, Dr Luca Penso Dolfin from TGAC's Vertebrate & Health Genomics Group, said: «As miRNAs are so important in orchestrating a variety
of cellular processes, the discovery of these 91 novel miRNAs provides a vital starting point to explore their potentially major effects on gene regulation.»
And given the importance of transcription in the growth and maturation of cells in general, the team's result stands to inform scientists about a variety
of cellular processes.