Sentences with phrase «of cellular proliferation»

Immunohistochemical demonstration of Cyclin D1 have become an important mean for assessing cell proliferation, therefore the immunohistological demonstration of cell cycle related antigens such as CDKs which regulated by the different cyclins could provide a good tool for assessment of cellular proliferation [11].

Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c - Kit in small cell lung cancer cells.

Not exact matches

Through the mTOR signalling pathway, it is involved in the regulation of many cellular processes, including cell survival, metabolism, proliferation, differentiation, and senescence.

When researchers suppressed the ARF gene in mole - rat cells during the reprogramming process to iPSCs, the cells stopped proliferation with sign of cellular senescence, while the opposite happens with mouse cells.

Recently, researchers have begun to describe the function of autophagy, a cellular recycling process critical for homeostasis, in germline stem - cell proliferation of C. elegans.

The gene plays a key role in cellular proliferation and is activated in 90 % of all human pancreatic tumors.

The laboratory of Marcos Malumbres, who is head of the Spanish National Cancer Research Centre's (CNIO) Cell Division & Cancer Group, working alongside Isabel Fariñas» team from the University of Valencia, shows, in a study published today in the journal Nature Communications, how in mice the elimination of the Cdh1 protein — a sub-unit of the APC / C complex, involved in the control of cell division — prevents cellular proliferation of rapidly dividing cells.

This is significant because IP4 controls cell proliferation, cellular metabolism and aspects of the immune system.

As described in the article, when NANOG was increased in these mice, the epithelia showed an increase in cellular proliferation, hyperplasia, and an increase in the amount of DNA damage in the cells.

Their findings outlined four distinct cellular phases of sperm stem cells maturation, revealing how the stem cells progress from a «quiescent» state, to a «proliferation» state during which stem cells divide, to a final «differentiation» state when stem cells mature to become sperm.

What makes this technique novel is the accompaniment of an imaging agent known as Ga - 68 DOTATOC, which binds to somatostatin receptors in neuroendocrine cells that use the hormone somatostatin to mediate endocrine function, the release of neurotransmitters and cellular proliferation.

In the Nature Communications study, UTSW researchers also reported how miR - 17 causes cyst proliferation: the molecule essentially reprograms the metabolism of kidney cells so that cellular structures called mitochondria use less nutrients, freeing up resources to instead make cell parts that become cysts.

Rho - kinase inhibitor treatment increased the cellular proliferation up to twofold during the first 12 h, and a wound model based migration assay showed 50 % faster filling of the mechanically generated wound area.

A proteomics analysis revealed expression changes of 56 proteins, and a further protein pathway analysis suggested their association with the cell morphology, the organization, and the increased cellular movement and the proliferation.

Studies have established that CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion and migration.

The cell cycle regulator p21 mediates the ability of the tumor suppressor p53 to arrest cellular proliferation.

Nuclear accumulation of the AT < sub > 1 receptor in a rat vascular smooth muscle cell line: effects upon signal transduction and cellular proliferation.

Because sorafenib inhibits the chemical signals that can trigger both cellular proliferation and new blood vessel growth, Gomberg - Maitland and colleagues suspected it might slow the growth and thickening of the pulmonary artery walls.

In particular, they are focused on studying the functional role and molecular mechanisms of cellular senescence in both of these events, and how a deregulation of normal epithelial stem cell proliferation is involved.

The damage that it will repair is the one that is causal in senenscence of DNA pathway (such x-ray radiation causing senescence) and oncogenic activated senescence; but not of the type of replicative senescence (that's the domain of telomeres / telomerase / sub-telomeres and epigenetics) and cellular replication / proliferation.

Cancerisation can result from perturbations at each of these levels and is linked to misregulation of developmental signalling pathways, uncontrolled cellular proliferation and a loss of cellular identity.

Examples of these include cell proliferation, intracellular targeting, cell polarity, membrane traffic, cell migration, stem cell biology, chromatin regulation and function, differentiation, morphogenesis and biomechanics, and regeneration and cellular homeostasis, as well as developmental roles of genes, cellular structural dynamics, and signaling pathways.

Long associated with enabling the proliferation of cancer cells, the ancient cellular survival response regulated by Heat - Shock Factor 1 (HSF1) can also turn neighboring cells in their environment into co-conspirators that support malignant progression and metastasis.

These biochemical mechanisms influence four different actions, which are cellular apoptosis, the inhibition of cell proliferation, the suppression of cytokine production and the reduction of white blood cells or leukocytes.

We have also identified a transcriptional signature of aneuploidy that is associated with cellular stress and slow proliferation, and is found in aneuploid primary and cancer cells across a host of organisms.

Metazoans can now be defined by a long list of genomic synapomorphies — gene content, intron — exon structure and syntenies — as well as characteristics common to all animal life such as sex, development, controlled cellular proliferation, differentiation and growth, and immunity.

To achieve this goal, the center's clinical and basic investigators are engaging in four distinct yet synergistic projects: 1) identifying mechanisms of abnormal cell proliferation, 2) examining the role of thrombosis in the development of PAH, 3) studying the role of nitric oxide deficiency in PAH, and 4) testing two existing drugs to restore lost cellular function due to a genetic mutation related to PAH.

Studies on the effects of GHRH antagonists on prostate and lung cancers demonstrated their ability to modulate signaling pathways involved in cellular proliferation, survival, metastasis, and apoptosis.

- Synthesis of specific inhibitors of beta - catenin The progressive accumulation of nuclear beta - catenin, which deregulates cellular proliferation, differentiation, and migration, is an initial event in the development of colonic tumorigenes.

Trastuzumab directly inhibits the proliferation of HER2 - overexpressing breast cancer cells and induces immune - mediated killing of target cancer cells through antibody - dependent cellular cytotoxicity [20].

From the European Commission Research & Innovation website: «Study investigates aquatic parasites on fish», Researchers in the Czech Republic, Spain and the United Kingdom have successfully identified the cellular components and mechanisms that play a role in the proliferation of myxozoa, tiny aquatic parasites responsible for diseases in commercially valuable fish.

Our results reveal cellular heterogeneity in the onset of HSC aging and implicate a role for JAK2V617F - driven proliferation in the p53 - mediated functional decline of old HSCs.

Significant drop in PSA levels (which is a biomarker of prostate cell growth); a drop in cholesterol (which is what we'd expect with a lower - fat diet, and all that extra fiber); and, importantly, a significant decrease in the cellular proliferation rate.

The vaccinated Purdue dogs also developed autoantibodies to laminin, which is involved in many cellular activities including the adhesion, spreading, differentiation, proliferation and movement of cells.

Unlike normal plasma cells, the malignant plasma cells look large and round with a high mitotic index (measure of the proliferation of a cell population) in early stages of cellular differentiation.

Cancer begins through mutations at the cellular level, which leads to an abnormal proliferation of abnormal cells.

Tornado detection has improved with the addition of NEXRAD, the growth of the trained spotter networks, storm chasers armed with cellular data and imagery and the proliferation of cell phone cameras and social media.