Sentences with phrase «of cellular protein»

Thus, at higher temperatures, eukaryotic phytoplankton seem to require a lower density of ribosomes to produce the required amounts of cellular protein.

Alternative splicing is commonly believed to be a major source of cellular protein diversity.

Hartl, a biochemist, and Horwich, a geneticist, are pioneers in the realm of cellular protein... Read more

Oligonucleotide - labeled antibodies allow integration of cellular protein and transcriptome measurements at a single - cell level, with the number of simultaneously assayed protein markers far surpassing what can be measured by cytometry - based approaches.

Hartl, a biochemist, and Horwich, a geneticist, are pioneers in the realm of cellular protein chemistry whose collaborations helped unravel the molecular machinery that assists with protein folding.

Modulation of cellular protein trafficking by human immunodeficiency virus type 1 Nef: role of the acidic residue in the ExxxLL motif.

As the primary site of cellular protein folding, the ER plays a critical role in maintaining cellular function.

With as many as a thousand tubes fitting into each cell, the tubular scaffold can be used to increase the bacteria's efficiency to make commodities and provide the foundation for a new era of cellular protein engineering.

Allan Jacobson, Ph.D., of the University of Massachusetts Medical School and co-founder of PTC Therapeutics, the company that developed ataluren, and David Bedwell, Ph.D., professor of the UAB Department of Biochemistry and Molecular Genetics, have sought to understand precisely how ataluren allows the ribosome, the machinery of cellular protein synthesis, to skip over these inserted stop signs and produce proteins that have normal or near - normal function.

Now, the research team discovered that the disruption of the cellular proteins pICln and Tgs1, two chief players that help assemble the splicing machinery, causes the fruit flies» neuromuscular system to collapse in a similar manner to patients with SMA.

They showed that ZIKV infection of cortical progenitors (stem cells for cortical neurons) controlling neurogenesis triggers a stress in the endoplasmic reticulum (where some of the cellular proteins and lipids are synthetized) in the embryonic brain, inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).

This interaction activates MALT1 to cleave and inactivate a number of cellular proteins that normally keep the immune system in check.

Based on some fundamental characteristics of cellular proteins, a team of scientists speculates that the last common ancestor of life on Earth got its start in the planet's natural hot tubs

A major component of the study was a comprehensive analysis of the «phosphoproteome» of prostate cancer tumors and cells, revealing changes in the phosphorylation states of cellular proteins.

The researchers also inhibited the synthesis of cellular proteins immediately after the training occurred.

This technology is based on observing drug induced changes in the thermal stability of cellular proteins.

Her lab also discovered a hidden regulatory landscape on the surfaces of cellular proteins, which act as traffic cops for telomerase.

Amy Gladfelter's «Companions in Discovery» follows her lab's investigations into the physical properties of cellular proteins by using the fungus, Ashbya, as a lab model.

They do not kill cancerous or viral cells, but regulate the action of specific genes that control the production of cellular proteins that affect cell growth.

(The rest is comprised of cellular proteins, such as enzymes, and fluid.)

Not exact matches

Frey's team did not train their system to predict diseases, but instead to take measurements of contents within a cell (metrics such as the concentration of a specific protein) and draw conclusions about the cellular system as a whole.

Geneticists passed from the formal genetics of individuals to cytogenetics at the cellular level, to the biochemistry of DNA in duplication and in protein synthesis at the molecular level, back to physiological and developmental genetics again at the cellular level and back to the level of the individual in behavioral genetics and beyond the individual to population genetics and the theory of evolution.

Like fellow Bay area start - up Geltor, Perfect Day is one of a new breed of companies in the «cellular agriculture» business — using genetically engineered yeasts that have been «programmed» to produce proteins or other ingredients found in plants or animals - on an industrial scale, without raising animals, and with less impact on the environment.

Unfortunately, 95 % of commercial protein powders have toxic ingredients that could be slowly inflaming your body and depleting the cellular nutrient stores.

Non-denatured whey protein is one of the best food sources for boosting cellular anti-oxidants such as glutathione which is your body's master antioxidant.

They are the building blocks of every structure in human skin; vital skin proteins like collagen, elastin, lipids and all cellular tissues are made from amino acids.

Once there, the protein acts on the osteoblasts and inhibits Wnt activity, which is a cellular signalling pathway that is involved in the formation of the skeleton and in certain disorders, such as osteoporosis, arthritis and myeloma.

Another symptom of NIV is cellular inflammation and leakage of proteins into the eye, which patients experience as cloudy vision, akin to looking through a fog, with occasional «floaters» or shadows, Mahajan explained.

The disruption of the microbiome reduced production of a key cellular protein vital to the barrier's effectiveness.

Degenerative brain diseases like mad cow disease (officially known as bovine spongiform encephalopathy, or BSE), scrapie in sheep, and vCJD in humans are thought to be caused by prions, misfolded versions of a normal cellular protein called PrPC.

The researchers found that the immune cells in the skin of this animal model generated large amounts of the cytokine IL - 17 — a protein of the immune system that activates cellular inflammation in response to damage.

«Many of these proteins already have a well understood day job, for example in cellular metabolism, and yet here they were interacting with RNA.

Proteins are not the only catalysts of cellular reactions; there is a growing list of RNA molecules that catalyze RNA cleavage and joining reactions.

Ribosomes, the cellular factories that manufacture proteins, contain both RNA and protein, but exactly how all of the different ribosomal components contribute to protein synthesis is still not clear.

The affected mitochondria could no longer provide the synapses with enough energy, which ultimately prevented the synapses from functioning — providing the first direct link between cellular injury caused by amyloid protein and the characteristic breakdown of neuronal communication that occurs in Alzheimer's patients.

They all use RNA molecules as messengers to transfer the information from DNA to cellular factories called ribosomes, which then build proteins, which in turn drive our metabolisms and form the structures of our cells.

They used this novel simulation approach to build a model of a sperm cell that demonstrates cellular movement from individual dynein protein molecules in the tail all the way up to the whole cell, allowing them to observe how changes at the atomic level are reflected in larger - scale structures.

She watched as four copies of p53 linked up and wrapped themselves around a DNA strand, an essential dance the protein performs before it sends off messages for cellular self - destruction.

A comparative analysis of the genomes ofDrosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae — and the proteins they are predicted to encode — was undertaken in the context of cellular, developmental, and evolutionary processes.

As a basic researcher, he has been most interested in looking for ideas that point toward new directions in the field: a new role for a protein or a new understanding of how cellular proteins drive the immune response.

«We are trying to understand the causes of aging by linking the mechanisms that control the oxidation of proteins at the cellular level with the mechanisms that determine the lifespan of the whole organism,» Apfeld says.

Previous research conducted at Mount Sinai found that the trafficking of protein molecules between the nucleus (the cellular compartment containing the genetic information of the cell) and the cytoplasm is altered in neurodegenerative disease.

With worms as his subjects, he plumbs the cellular mechanisms driving the complex protein interactions regulating lifespan, some of which — remarkably — have been conserved through evolution all the way from his microscopic Caenorhabditis elegans to us.

When cells become cancerous, tremendous stresses are placed on the cellular machinery responsible for maintaining protein equilibrium — and that machinery is the target of anti-cancer drugs called proteasome inhibitors.

Although no functions could be assigned to three of the proteins, bioinformatics analysis suggested that the remainder are involved in a wide range of biological processes, including reproduction, cellular metabolic processes, multicellular organismal growth, developmental processes, growth, locomotion, response to stimuli, localization and biological regulation.

Therefore, cells have developed another strategy to get rid of faulty mitochondrial proteins and maintain cellular homeostasis,» says Park.

A common feature of neurodegenerative diseases such as Alzheimer's, Parkinson's or Huntington's disease are deposits of aggregated proteins in the patient's cells that cause damage to cellular functions.

Purdue University physicists are part of an international group using spinach to study the proteins involved in photosynthesis, the process by which plants convert the sun's energy into carbohydrates used to power cellular processes.

These long - lived worms had mutations that decreased the production of a protein known as insulinlike growth factor 1 (IGF - 1), which helps drive cellular growth and division.

In the living world, transmembrane proteins are found embedded in the membrane of all cells and cellular organelles.