Sentences with phrase «of cellular proteins»

As the primary site of cellular protein folding, the ER plays a critical role in maintaining cellular function.

This technology is based on observing drug induced changes in the thermal stability of cellular proteins.

The researchers also inhibited the synthesis of cellular proteins immediately after the training occurred.

Hartl, a biochemist, and Horwich, a geneticist, are pioneers in the realm of cellular protein chemistry whose collaborations helped unravel the molecular machinery that assists with protein folding.

Amy Gladfelter's «Companions in Discovery» follows her lab's investigations into the physical properties of cellular proteins by using the fungus, Ashbya, as a lab model.

Now, the research team discovered that the disruption of the cellular proteins pICln and Tgs1, two chief players that help assemble the splicing machinery, causes the fruit flies» neuromuscular system to collapse in a similar manner to patients with SMA.

Stewart says his team's initial work has not only identified fibrillarin as essential for viable paramyxovirus replication — it also has shown that one can «deplete fibrillarin from cells or block its catalytic activity and the vast majority of cellular proteins still get made within the cell,» which suggests it is a safe target for intervention.

Allan Jacobson, Ph.D., of the University of Massachusetts Medical School and co-founder of PTC Therapeutics, the company that developed ataluren, and David Bedwell, Ph.D., professor of the UAB Department of Biochemistry and Molecular Genetics, have sought to understand precisely how ataluren allows the ribosome, the machinery of cellular protein synthesis, to skip over these inserted stop signs and produce proteins that have normal or near - normal function.

This interaction activates MALT1 to cleave and inactivate a number of cellular proteins that normally keep the immune system in check.

These findings provide important novel insights into the mechanisms of cellular protein quality control as well as disease progression» Hartl concludes.

The enzymes modify the activity of cellular proteins, ultimately killing the cell.

With as many as a thousand tubes fitting into each cell, the tubular scaffold can be used to increase the bacteria's efficiency to make commodities and provide the foundation for a new era of cellular protein engineering.

Based on some fundamental characteristics of cellular proteins, a team of scientists speculates that the last common ancestor of life on Earth got its start in the planet's natural hot tubs

A major component of the study was a comprehensive analysis of the «phosphoproteome» of prostate cancer tumors and cells, revealing changes in the phosphorylation states of cellular proteins.

Some of Gierasch's more recent work has been focused on developing and testing experimentally a computational model of cellular protein homeostasis in E. coli in collaboration with Evan Powers of The Scripps Institute.

Her lab also discovered a hidden regulatory landscape on the surfaces of cellular proteins, which act as traffic cops for telomerase.

Oligonucleotide - labeled antibodies allow integration of cellular protein and transcriptome measurements at a single - cell level, with the number of simultaneously assayed protein markers far surpassing what can be measured by cytometry - based approaches.

These cells produce high levels of IL - 22 upon stimulation with IL - 23 and their use permitted both semi-quantification of transcript expression and visualization of cellular protein and phospho - protein levels by western blot.

The tail ends of cellular protein templates, regions often thought relatively inconsequential, may actually play a role in preventing normal cells from becoming cancerous.

The Church Lab is currently analyzing mutations in DNA regions that regulate the expression of genes — the on / off and volume knobs of cellular proteins and pathways.

They do not kill cancerous or viral cells, but regulate the action of specific genes that control the production of cellular proteins that affect cell growth.

(The rest is comprised of cellular proteins, such as enzymes, and fluid.)

Thus, at higher temperatures, eukaryotic phytoplankton seem to require a lower density of ribosomes to produce the required amounts of cellular protein.

Hartl, a biochemist, and Horwich, a geneticist, are pioneers in the realm of cellular protein... Read more

However, in a 2015 paper, Tonegawa and his colleagues showed for the first time that memories could be stored even when synthesis of the cellular proteins is blocked.

They showed that ZIKV infection of cortical progenitors (stem cells for cortical neurons) controlling neurogenesis triggers a stress in the endoplasmic reticulum (where some of the cellular proteins and lipids are synthetized) in the embryonic brain, inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).