Sentences with phrase «of cellular receptors»

Myasthenia gravis is caused by a reduction or deficiency in the number of cellular receptors for a specific neurotransmitter, acetylcholine, at the junctions between nerve endings and skeletal muscle cells.

Earlier this year, they reported the identification of the cellular receptor that binds the toxin.

Not exact matches

Beta blockers bind to both types of receptor, but do not activate the cellular response.

Clinically important findings suggest that targeting the epidermal growth factor receptor (EGFR) and the fibroblast growth factor receptor (FGFR) cellular pathways may benefit thousands of patients with this disease, according to the study published today in the journal PLOS Genetics.

If one component was missing in this triplet consisting of auxin transporter, receptor or calcium channel, there was no cellular response.

Cell lines are the workhorses of biology, routinely stocked and studied in every laboratory to understand cellular pathways, receptors, targets, hormones, and all aspects of normal and malignant physiology.

In their study, the Geneva researchers were also able to dissect the fine cellular mechanisms involved: Of the three estrogens receptors, only one is mainly involved in this protective effect.

Many of those efforts have focused on drugs that target cellular receptors in the brain called NMDA receptors.

Scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have identified a cellular receptor for rhinovirus C, a cold - causing virus that is strongly associated with severe asthma attacks.

Bex acts on a «master regulator» protein called retinoid X receptor (RXR), which controls a network of other cellular proteins.

«Lots of things bind to heparan sulfate to trigger various cellular responses, but when active heparanase levels are high, the receptors become degraded, so bound molecules are released and can cause damage to the local tissues,» said Agelidis.

NMDA receptors are key players in plasticity, the cellular process of learning and memory.

To create a more realistic mouse model of low MD activity, the team devised a new method that uses a virus to embed into the surface of MD neurons receptors that block cellular activity in the presence of a compound called clozapine - N - oxide.

University of North Carolina researchers uncovered a cellular mechanism by which kappa opioid receptors (KOR) drive anxiety.

What makes this technique novel is the accompaniment of an imaging agent known as Ga - 68 DOTATOC, which binds to somatostatin receptors in neuroendocrine cells that use the hormone somatostatin to mediate endocrine function, the release of neurotransmitters and cellular proliferation.

During the early years of my PhD studies, I was very fascinated by the exciting discoveries in the field of signal transduction, in particular how receptor tyrosine kinases are activated to transmit their signals and how protein complexes are formed through defined protein folds (domains) interacting with specific cellular targets.

The tongues of most mammals hold taste receptors — proteins on the cellular surface that bind to an incoming substance, activating the cell's internal workings that lead to a signal being sent to the brain.

«Our experiments suggest that mGluR5 amplifies the cellular response to a chemical signal, and that by blocking mGlur5 receptors in inhibitory neurons involved in depression, these new therapies can achieve an antidepressant effect,» says senior author Paul Greengard, Vincent Astor Professor and head of the Laboratory of Molecular and Cellular Neuroscience.

Once receptors sense the presence of these binding partners, they send out new signals that initiate other cellular processes.

Bone loss in models of leptin or leptin receptor deficiency has been linked with lower osteoblast activity (9, 14), suggesting that cellular leptin resistance in obesity might reduce bone formation.

To measure and compare concentrations, cells count stochastic binding events of signalling molecules that diffuse to cellular receptors.

In situ hybridization on sections of gustatory ganglia (geniculate, petrosal / nodose) and a somatosensory ganglion (trigeminal) were performed to reveal serotonin receptor gene expression at the cellular level.

Precious patient samples, contamination concerns, and limited product purification options have compelled manufacturers of cellular immunotherapies (iTx) such as chimeric antigen receptor T cells (CAR - T) and T - cell receptor (TCR) technologies toward the disposables industry.

The dynamic equilibrium between binary and ternary complexes was found to be regulated by the negative feedback inhibitor USP18, which explains how differential cellular activity of IFNs is correlated with their receptor binding activity.

Our lab is interested in identifying the cellular and molecular mechanisms involved in the organization and maintenance of the synapse with a specific focus on the control of neurotransmitter receptor expression and localization.

These CARs contain two fused parts: an antibody that protrudes from the surface of a T - cell to recognise a protein on cancerous B - cells (commonly CD - 19) in the blood and a receptor inside the T - cell that sends messages to cellular machinery.

Employing a combination of cellular, biochemical and genetic experiments, we showed that (i) human and murine pericytes express functional Tie2 receptor, (ii) Tie2 - silenced pericytes have a pro-migratory phenotype, (iii) Tie2 downstream signalling in pericytes involves Calpain, Akt and FOXO3A, (iv) Ng2 - Cre - driven deletion of pericyte - expressed Tie2 delays developmental angiogenesis and vessel maturation, and (v) Tie2 deletion in pericytes results in a pro-angiogenic tumour vasculature with enhanced tumour growth.

The lab's findings in the study, «D - serine Deficiency Attenuates the Behavioral and Cellular Effects Induced by the Hallucinogenic 5 - HT2A Receptor Agonist DOI,» suggested that D - serine - dependent NMDAR activity is involved in mediating the cellular and behavioral effects of 5 - HT2AR activation.

For instance, three scavenger receptor genes were suggested to facilitate the cellular uptake of carotenoids in the adductor muscles of orange - adductor Yesso scallop [13].

Areas of particular interest are host - pathogen interactions, pattern recognition receptors, cellular signaling and immunometabolism, and myeloid cell development.

G protein - coupled receptors (GPCRs) are actually a huge protein family (i.e., superfamily) of transmembrane receptors that sense molecules outside Eukaryotic Cells in species ranging from yeast to humans, and activate very basic biological pathways and cellular responses inside the cells.

Nuclear accumulation of the AT < sub > 1 receptor in a rat vascular smooth muscle cell line: effects upon signal transduction and cellular proliferation.

LAMP2A: The A variant of lysosome - associated membrane protein 2 is a receptor involved in the cellular maintenance processes of autophagy, but levels decrease with age, and in at least some species this appears to be one of the factors involved in the age - related decline of autophagy.

After graduating, Clara moved to the UK to work as a Research fellow with Prof John Findlay at the University of Leeds, working mainly with Lipocalins and their cellular receptors, identifying structural binding / transport motifs and investigating the physiological link between vitamin A uptake and Type 2 Diabetes.

In particular, the cAMP signaling cascade directs adaptive cellular responses to a variety of stress stimuli via a combination of acute affects arising from GS - protein coupled receptor (GPCR)- mediated activation of PKA and long - term affects resulting from transcriptional reprogramming directed by CREB and the CREB Regulated Transcription Coactivators (CTRCs).

Title: Expression of a1adrenergic receptors in rat prefrontal cortex: cellular colocalization with 5HT2A receptors Author: N. Santana et al..

Further, there is evidence to suggest that AGEs produce raised levels of chronic inflammation by altering cellular behavior through the receptor for AGEs, RAGE.

This family of proteins is responsible for a vast array of cellular communication — including the light - sensing molecules in your retinas, the sugar sensors in your gut, and many of the neurotransmitter receptors that underlie the thoughts and emotions that move through your brain — and these proteins are the targets of the vast majority of pharmaceutical drugs.

Nanolithographic control of the spatial organization of cellular adhesion receptors at the single - molecule level.

Huntingtin null neurons exhibit a significant reduction in transcripts encoding proteins destined for the extracellular space, many of which are components of the extracellular matrix or involved in cellular adhesion, receptor binding and hormone activity.

In the worm, we are developing tools to monitor neuromodulation at cellular resolution in an intact brain and using them to directly measure endogenous peptide release and binding to receptors on identified neurons using real - time approaches for imaging neuropeptide signaling, in order to understand the dynamics of this process in a living animal.

Here, we tested whether human gastric cancers, which are among the most aggressive tumor entities, express the cellular receptor of Shiga toxin, the glycosphingolipid globotriaosylceramide (Gb3 / CD77).

Beyond the internal interactions of the protein itself, these designed oligomers can be used to explore basic questions about how the structure of signaling molecules affects the behavior of receptors and cellular response.

Whitehead Institute scientists report that patients whose estrogen receptor (ER)- positive breast cancers have high levels of an ancient cellular survival factor experience poor outcomes — including increased mortality.

The process uses a computational model to generate predictions about the dynamics of cell receptors in different cellular compartments.

3/29/2007 UCSD Researchers Identify Critical Receptor in Liver Regeneration In studies in mouse models, researchers at the University of California, San Diego (UCSD) School of Medicine have found that A hepatic stellate cell activated by the p75 Neurotrophin Receptor promotes repair in the livera cellular recept... More...

Our strong expertise allows us study lipid - protein interaction based phenomena at different scales, from the organ and cellular systems down to minimal synthetic systems in which we can control the proteins as well as the lipid, for instance to monitor the allosteric effects of specific lipids on fundamental receptors such as the EGF receptor (Coskun et al (2011) PNAS) and the insulin receptor.

The complex networks, interactions, and responses of immune cells produce diverse cellular ecosystems composed of multiple cell types, accompanied by genetic diversity in antigen receptors.

Turmeric is one of those few natural substances that work by directly blocking estrogen receptors on the cellular level, hence having the effect of reducing the sensitivity of your breast tissue to estrogen.

Unlike other breast cancers that involve hormone receptors and HER2 receptors, this aggressive form of cancer relies on genetic therapeutics aimed at repairing celluar DNA and keeping epidermal growth factors from sending cellular signals.