Sentences with phrase «of cellular senescence»

The biological process of cellular senescence represents an ideal paradigm to examine the role of the DNA damage response, epigenetically determined chromatin structure, and metabolic reprogramming during tissue aging and cancer development.

This may well be more a sign of the times, a measure of the increasing interest in the research community directed towards the role of cellular senescence in aging, rather than something that arises organically.

Again, then, there is significant evidence consistent with a role of cellular senescence in age - related lipodystrophy and lipoatrophy, and for the benefits observed in treated mice in these studies to translate into aging humans.

Investigators studied liver tissue from patients with steatohepatitis, who were heavy alcohol drinkers, and from ethanol - fed mice to identify biochemical markers of cellular senescence.

When researchers suppressed the ARF gene in mole - rat cells during the reprogramming process to iPSCs, the cells stopped proliferation with sign of cellular senescence, while the opposite happens with mouse cells.

This series addresses the contribution of cellular senescence to cardiovascular, neurodegenerative, and arthritic disorders as well as the senescent phenotypes in various tissues and cell types.

As an assistant professor at the Boston University Medical School, she became interested in the control of cellular senescence and its role in tumor suppression and aging.

1: Rodier F, Campisi J. Four faces of cellular senescence.

We have shown that the human condensin complex functions in global 3D genome reorganization during the important process of cellular senescence (Yokoyama et al..

This project has the potential to uncover clinically relevant mechanisms of cellular senescence in fibrosing ILDs and identify new therapeutic targets

Potential biomarkers include chronic inflammatory markers, markers of cellular senescence, and sarcopenia.

A growing body of evidence suggests that the process of cellular senescence is driven by changes in the protein complexes called chromatin in the nuclei of cells.

In this proposal, we will further develop this microscopy to achieve 3D, multicolor, and live - cell, super-resolution imaging capabilities, so as to record a 3D time - lapsed movie of the formation of SAHF during the process of cellular senescence.