Sentences with phrase «of cellular stress»

Current scientific efforts aim at elucidating the function of mitochondrial Hsp90s in tumor bioenergetics, the regulation of the cellular stress response and the resistance to conventional and targeted anticancer regimens.

of aberrant amyloid and tau in the retina, quantification of any neuronal degeneration, delineation of cellular stress responses of neurons and particularly glial cells, and investigation of oxidative stress.

Placentas had underdeveloped blood vessels, the barrier between mother and fetal cells was abnormal, and researchers spotted evidence of cellular stress.

«The stability of BOK appears to be directly related to the amount of cellular stress experienced within the endoplasmic reticulum.»

Oxidative states are generally considered to be indicative of cellular stress; however, cells inherently release harmful reactive oxygen species during energy production, neutralized by intracellular antioxidative buffering systems.

«It turns out that the enhanced MAM formation in obesity is too much of a good thing, leading to functional failure of multiple organelles and amplification of cellular stress,» Hotamisligil said.

Numerous studies have demonstrated activity of these agents against a wide variety of cancers, especially cancer stem cell - like subpopulations, by a host of different mechanisms which comprise inhibition of signaling pathways, of mitochondrial respiration, as well as of cellular stress responses and others.

My lab at HPU studies membrane traffic during times of cellular stress using baker's yeast as a model system.

Scientists have known that, in organisms ranging in complexity from yeast to humans, different kinds of cellular stress — such as a backlog of unfolded proteins, DNA - damaging UV light, a shortage of the amino acid building blocks needed to make protein, viral infection, iron deficiency — trigger different enzymes to act downstream to switch off eIF2 alpha.

Trudu M, Schaeffer C, Riba M, Ikehata M, Brambilla P, Messa P, Martinelli - Boneschi F, Rastaldi MP, Rampoldi L. Early involvement of cellular stress and inflammatory signals in the pathogenesis of tubulointerstitial kidney disease due to UMOD mutations.

The researchers demonstrated that this stabilizes elF2B and helps it maintain protein production in the face of cellular stress.

Previously, Walter's team discovered that ISRIB (short for «integrated stress response inhibitor») blocks this aspect of the cellular stress response by enhancing the activity of a protein called eIF2B, which helps keep a key protein production line operating in stressed cells.

Analytical endpoints included examination... of aberrant amyloid and tau in the retina, quantification of any neuronal degeneration, delineation of cellular stress responses of neurons and particularly glial cells, and investigation of oxidative stress.

Experiments proved that Heat Shock Factor 1 (HSF1), a sort of protective switch against some types of cellular stress, could bind to the TTR gene's promoter (a segment of DNA near the TTR gene).

And, if that weren't enough, it also helps repair some of the cellular stress caused by exercise.