Sentences with phrase «of cellular stress responses»

Analytical endpoints included examination... of aberrant amyloid and tau in the retina, quantification of any neuronal degeneration, delineation of cellular stress responses of neurons and particularly glial cells, and investigation of oxidative stress.

of aberrant amyloid and tau in the retina, quantification of any neuronal degeneration, delineation of cellular stress responses of neurons and particularly glial cells, and investigation of oxidative stress.

Numerous studies have demonstrated activity of these agents against a wide variety of cancers, especially cancer stem cell - like subpopulations, by a host of different mechanisms which comprise inhibition of signaling pathways, of mitochondrial respiration, as well as of cellular stress responses and others.

Previously, Walter's team discovered that ISRIB (short for «integrated stress response inhibitor») blocks this aspect of the cellular stress response by enhancing the activity of a protein called eIF2B, which helps keep a key protein production line operating in stressed cells.

Not exact matches

Intermittent fasting, regular exercise and consumption of dietary phytochemicals can have a major positive impact on health by bolster - ing adaptive cellular stress response pathways that protect against and counteract a range of major diseases.

They showed that ZIKV infection of cortical progenitors (stem cells for cortical neurons) controlling neurogenesis triggers a stress in the endoplasmic reticulum (where some of the cellular proteins and lipids are synthetized) in the embryonic brain, inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).

The third parameter — the spatial distribution of NADH in the cells — shows how the mitochondria split and fuse in response to cellular growth and stress.

Importantly, Zika virus also follows the same pattern of cellular behavior of repressing the cell's translation and stress response while promoting its own protein translation.

Another part of the stress response takes remaining untranslated cellular RNAs and gloms them together into structures called stress granules.

Although other tRNA halves have been described before — specifically those that are produced during a cellular stress response — this discovery represents a new and distinct species of tRNA halves that the authors coined SHOT - RNAs, for sex hormone dependent tRNA - derived RNAs.

In the past 27 years, we have found that this cycling sugar modification of proteins — called O - linked N - acetylglucosamine, or O - GlcNAc — is nearly as common as protein phosphorylation and often competes with it at the same or proximal sites on proteins to regulate nearly every cellular process in response to nutrients and stress.

The laboratory's interest is the stress response and the interplay between DNA repair and other cellular processes including transcription and chromatin remodeling, and is focused on elucidating the function and mechanochemistry of DNA - based motors using a combination of biochemical, biophysical and structural techniques.

Their activity increases in response to heat, toxins, and various other forms of cellular stress, and dialing up the activity of heat shock proteins is involved in a number of methods demonstrated to slow aging in laboratory animals.

Inhibition of c - Abl with STI571 attenuates stress - activated protein kinase activation and apoptosis in the cellular response to 1 - β - d - arabinofuranosylcytosine.

In particular, the cAMP signaling cascade directs adaptive cellular responses to a variety of stress stimuli via a combination of acute affects arising from GS - protein coupled receptor (GPCR)- mediated activation of PKA and long - term affects resulting from transcriptional reprogramming directed by CREB and the CREB Regulated Transcription Coactivators (CTRCs).

Altieri and his team are currently focused on three programs to understand the biology of survivin with respect to cell cycle progression, in particular, mitosis, cell survival and the cellular stress response and how exploiting these pathways may provide new cancer therapeutics.

Characterizing the molecular pathways regulating genomic stability at damaged replication forks in HR - deficient cancers will increase our understanding of the cellular response to replicative stress, and in the same time, potentially allow the identification of new predictors (biomarkers) of chemo - sensitivity / resistance in these tumors (Figure 2B).

Manuscripts typical of this section would describe experiments generating and analyzing lists of genes and studies of how those genes combine to regulate: differentiation of a particular cell type; cellular, tissue, or organ response to toxic / pathogenic agents; adaptation to environmental stresses.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

September 10, 2015 Protein aggregation after heat shock is an organized, reversible cellular response Protein aggregates that form after a cell is exposed to high, non-lethal temperatures appear to be part of an organized response to stress, and not the accumulation of damaged proteins en route to destruction.

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

While some cortisol is absolutely necessary to live — this is the hormone that is released from your adrenal glands in a cyclic manner during the day or during times of stress — most of us exist in a state of nearly constant exposure to this compound, resulting in lowered blood sugar response, abdominal weight gain, decreased memory, reduced cellular energy production, and diminished immunity.

102, 103 One proposed mechanism thought to mediate these effects is an up - regulation of cellular stress resistance in response to ER, which may occur via a process called hormesis.

By practicing specific yoga poses, we place certain amounts of therapeutic stress (called the «Goldilocks Position») on our connective tissues, gently creating tiny piezoelectric currents that in turn stimulate optimal cellular responses.

Autophagy, a cellular cleaning process, gets activated in response to certain types of metabolic stress, including nutrient deprivation, growth factor depletion and hypoxia.

In response to this lack of cellular fuel, the brain triggers the release of cortisol which is the body's primary stress hormone.

This «system» regulates reproduction; growth and development; cellular metabolism; the balance of nutrients, electrolytes and water and acts to mobilize the body's stress response.

A multitude of plant hormetic compunds such as polyphenols, flavanols, luteolin, apigenin, anthocyanins, and pterostilbene — these compounds actually induce a small stress response in our cells which build cellular resilience and health

We can measure the response of inflammation by way of biomarkers of cellular damage, which are indicative of oxidative stress.

«Hormesis in aging is defined as «life - supporting beneficial effects resulting from the cellular responses to single or multiple rounds of mild stress.»

Among berries, I mostly consume strawberries (daily morning smoothie with a cup of frozen strawberries, half banana, cup water, 3 tbsp flax seed, 2 tbsp wheat germ), as their flavonoid, fisetin, appears particularly potent in inducing cellular stress responses and crossing the blood brain barrier.

Reactive oxygen species trigger cellular responses by activation of stress - responsive mitogen - activated protein kinase (MAPK) signalling pathways.

Consistent with having a lower temperature tolerance, longfin smelt exhibited a pronounced cellular stress response, with an upregulation of heat shock proteins, after exposure to 20 °C that was not observed in delta smelt.