However brains lacking BRCA1 exhibit high levels
of cellular suicide (green, second column).
Lieberman, Dotiwala and their team were particularly struck by how much the granzyme - sparked cascade resembles apoptosis, a controlled form
of cellular suicide that helps eliminate damaged or potentially cancerous cells.
After earning a PhD studying feline leukemia virus in relative obscurity at the University of Washington, Seattle, I found myself as an American ex-pat in London, examining the ins and outs
of cellular suicide in the lab of a famous man in a prestigious institute.
They also tested other chemicals known to prevent the other two forms
of cellular suicide, but only CGP3466B protected mouse nerve cells in the brain from death by cocaine.
Not exact matches
One, apoptosis, is a form
of controlled
cellular suicide, usually for the benefit
of the organism.
In an attempt to protect the body from the spreading virus, these immune cells then commit «
cellular suicide,» leading to the collapse
of the immune system — and AIDS.
However, once women stop breastfeeding, these structures self - destruct — a process that involves massive
cellular suicide, and the removal
of the debris.
Now, Professor Martin and colleagues have discovered that in response to specific types
of cell damage, Parkin can trigger the self - destruction
of «injured» nerve cells by switching on a controlled process
of «
cellular suicide» called apoptosis.
In this new paper, the researchers reveal more about that mechanism, showing that without the protective ability
of BRCA1, breaks in the DNA strands go unfixed, prompting the molecule ATM kinase to activate a
cellular «
suicide» pathway involving a protein called p53.
Studies have shown gamma - tocotrienol selectively targets cancer cells, triggering
cellular senescence and promoting apoptosis — a type
of programmed cell
suicide.