Sentences with phrase «of cellular survival»

Germ - line cells are the all - time champions of cellular survival.

Not exact matches

The cryotherapy process reduces inflammation for pain relief and improved mobility by decreasing the cellular metabolism, pain and spasm while increasing cellular survival and the levels of oxygenated blood delivered to damaged tissue.

The presence of nicotine increases the amount of intracellular calcium, which appears to improve cellular survival.»

We also observed that HIV rewires cellular defensive pathways to benefit survival of the virus,» he added.

Some of those matching genes are vital for embryo survival, including several responsible for cell communication, cellular energy and adhesion to the lining of the uterus.

Through the mTOR signalling pathway, it is involved in the regulation of many cellular processes, including cell survival, metabolism, proliferation, differentiation, and senescence.

Like removing unnecessary lighting from a financially strapped household to save on electricity bills, the drug — called rapamycin — prolongs the survival of diseased neurons by forcing them to reduce protein production to conserve cellular energy.

«We think that lack of SOD1 could be priming the muscle to use all of its survival skills,» said Holly Van Remmen, Ph.D., professor of cellular and structural biology in the School of Medicine and associate director for basic research at the Barshop Institute.

We believe there is an undiscovered world of biology that allows different kinds of cells to synthesize protein at different rates and in different ways, and that those differences are important for cellular survival.»

As a result, they are currently being investigated as a cellular therapeutic for the treatment of autoimmune diseases and long - term patient and graft survival following solid organ transplantation, and allogeneic hematopoietic stem cell transplantation.

Here we report the generation of additional mutant Xpd alleles that fail to support viability on their own but nevertheless ameliorate TTD - associated premature segmental ageing, cutaneous features, cellular DNA repair capacity, and UV survival when present in a compound heterozygote state.

Antibiotics stop or interfere with a number of everyday cellular processes that bacteria rely on for growth and survival, such as:

Moreover; the PI3K / AKT pathway also can contribute to melanoma tumorigenesis through mutations or loss in PTEN and dysregulation in expression of AKT, which positively regulates the G1 / S phase progression in cell cycle, suppresses apoptosis and promotes cellular survival.

This work aims to investigate, mechanistically, the molecular processes related to dysregulation of factors that normally protect the eye against oxidative stress, thus impairing RPE and photoreceptor cellular metabolism and their survival in AMD.

Shorter patient survival was generally associated with up - regulation of genes involved in mitosis and cell growth, and down - regulation of genes involved in cellular differentiation.

Current efforts focus on elucidating the role of molecular chaperones compartmentalized in mitochondria in regulating tumor bioenergetics, adaptation to cellular stress and cell survival.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

Altieri and his team are currently focused on three programs to understand the biology of survivin with respect to cell cycle progression, in particular, mitosis, cell survival and the cellular stress response and how exploiting these pathways may provide new cancer therapeutics.

Long associated with enabling the proliferation of cancer cells, the ancient cellular survival response regulated by Heat - Shock Factor 1 (HSF1) can also turn neighboring cells in their environment into co-conspirators that support malignant progression and metastasis.

Whitehead Institute scientists report that patients whose estrogen receptor (ER)- positive breast cancers have high levels of an ancient cellular survival factor experience poor outcomes — including increased mortality.

A small molecule activator of p300 / CBP histone acetyltransferase promotes survival and neurite growth in a cellular model of Parkinson's Disease

Vignali and his colleagues used a variety of molecular and cellular techniques to show that Sema4a binding to Nrp1 turns on a biochemical pathway in mouse regulatory T cells that enhances their function, stability and survival.

Studies on the effects of GHRH antagonists on prostate and lung cancers demonstrated their ability to modulate signaling pathways involved in cellular proliferation, survival, metastasis, and apoptosis.

As a monolayer of cells critical to photoreceptor function and survival, the RPE is an ideally accessible target for cellular therapy.

His laboratory at Stanford University School of Medicine is developing novel stem cell and nanotherapeutics approaches for ocular repair, studying retinal ganglion cell development, survival and axon regeneration in glaucoma, and investigating the cellular basis for the developmental loss of axon growth ability.

It involves cell degradation of unnecessary or dysfunctional cellular components, which ensures cellular survival during starvation by maintaining cellular energy levels.

Also noted by IER studies are an increase in the expression levels of silent mating type information regulation 2 homolog 1 (SIRT1), an NAD + - dependent deacetylase.20 The expression of SIRT1, also increased by prolonged ER in rodents, is linked to the up - regulation of cellular stress resistance and improved outcomes in animal models of metabolic, neurodegenerative and inflammatory diseases.106, 107These findings have been suggestively accompanied by improvements in resilience to disease progression in rodent models of Type 1 diabetic nephropathy 20, survival following induced ischaemic injury 21 and a reduction in oxidative stress.105

Similar to the physical and cellular burn of exercise that creates some oxidizing free radicals, the «stress» from cruciferous vegetables stimulates our mitochondria to produce homemade antioxidants to counterbalance the oxidation and protect our vital DNA.28 Even cancer cells have caught on to this central role of our mitochondria — the bastards can amplify their levels of some of these same pathways — further stressing their importance for survival.25 However, our cells still seem to have the upper hand, as multiple studies show that the organosulfur chemicals in many of these anticancer vegetables can severely stress cancer cells, leading to oxidative damage, and ultimately, death.29

When it senses cold, it will increase the rate of cellular activity to keep the core temperature optimal for survival.

PQQ is a co-factor compound for a special class of enzymes involved in cellular function including cellular growth, development, differentiation, and survival.

From plants to metazoans, an increase in intracellular levels of NAD + directs cells to make adjustments to ensure survival, including increasing energy production and utilization, boosting cellular repair, and coordinating circadian rhythms.

«The genotoxicity of mainstream smoke carcinogens manifests as mutations occurring in key cancer - related genes, i.e., proto - oncogenes or tumor suppressor genes that control crucial cellular functions, e.g., growth and survival, in lung tumors of active smokers.»