Sentences with phrase «of cerebellar»

We nevertheless conducted an analysis of cerebellar volume and age in SM - negative CKCS to see if this was a potential source of bias.

Dandy Walker - Like Malformation (DWLM) is a form of cerebellar ataxia which is inherited as an autosomal recessive trait.

Furthermore, the degree of cerebellar crowding in the caudal CCF is correlated with increased volume of the cerebellum in CKCS and this is not seen in small breed dogs or Labradors.

The possibility of a cerebellar growth disorder also deserves scrutiny.

Primary defects of the cerebellum include Lhermitte - Duclos disease [33], in which a slow - growing harmatoma causes diffuse hypertrophy of the cerebellar stratum granulosum.

However, there are only a few rare syndromes of cerebellar overgrowth in humans which do not involve generalised brain overgrowth.

These parameters are accepted standards in canine brain volume measurement as they have been used in a study of cerebellar atrophy [22] and CCF parenchyma volume [18], [19].

In particular the conformation of the craniocervical junction varies and in some individuals the size of cerebellar herniation may be minimal [3].

In order to assess the clinical significance of cerebellar volume and CCF volume as prognostic indicators, further cohort and longitudinal studies are needed.

It has been found that pre-natal posterior cranial fossa development in humans is independent of cerebellar volume but closely parallels the development of the supratentorial bony compartment [43].

However in some individuals the size of cerebellar herniation may be minimal [2].

Clinical signs are typical of a cerebellar disorder and include tremors, ataxia, and hypermetria.

Arnold — Chiari malformation is a complex malformation of the caudal brain stem and cerebellum and typically consists of herniation of cerebellar tissue through the foramen magnum into the cervical spinal canal.

A selective hypoplasia of the cerebellar vermis is also seen in dogs, and when combined with hydrocephalus and cyst - like dilatation of the fourth ventricle, the condition has been termed the Dandy - Walker syndrome, which may have a familial basis.

The tumors tend to bulge into the fourth ventricle, often replacing part of the cerebellar vermis and compressing the midbrain rostrally and the brain stem ventrally.

A clinical diagnosis of cerebellar abiotrophy is best obtained through a neurological examination by an ACVIM board - certified neurologist, in consultation with Dr. Olby.

To understand the diagnosis of cerebellar abiotrophy (CA) in the Old English Sheepdog, you must understand the condition.

Affected dogs typically exhibit a condition of cerebellar dysfunction in which voluntary muscular movements tend to result in the movement of bodily parts beyond the intended goal and the loss of the abilityto coordinate muscular movement.

Although in humans almost all chiari malformation patients has some degree of cerebellar herniation, in dogs cerebellar herniation is not that common and this is the main difference between these 2 species.

Symptoms of cerebellar ataxia typically develop slowly over the course of several months or years and they include swaying, abnormal gait, loss of coordination, tremors, falling, and weakness.

There are several types of cerebellar abiotrophy, which include neonatal (before birth), postnatal (after birth), and extrapyramidal nuclear abiotrophy, in which other cells besides Purkinje cells are destroyed.

The cause of cerebellar abiotrophy is not known, but it is presumed to be congenital in certain breeds such as:

From Neurons to Neuron Neighborhoods: the Rewiring of the Cerebellar Cortex in Essential Tremor

This study indicates microstructural damage of the cerebellar white matter in familial cortical myoclonic tremor with epilepsy.

Joseph G. Gleeson, M.D. University of California - San Diego School of Medicine Causes and pathogenesis of cerebellar malformation syndromes in humans: bedside to bench

Topographical organization of the cerebellar cortical projection to nucleus interpositus anterior in the cat.

The second paper identified a link between a protein used in coenzyme Q synthesis and the development of cerebellar ataxia, which leads to abnormalities in balance, gait and eye movement.

Consensus Paper: Towards a Systems - Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex..

Primary cultures of cerebellar neurons from neonatal rats allow for examinations of the developmental neurotoxicity of chemicals because the various stages of neurodevelopment — including proliferation, migration, differentiation, and morphological and functional maturation — can be observed in vitro.

The team hopes that the results will lead to a greater understanding of a range of cerebellar disorders.

The p75 neurotrophin receptor can induce autophagy and death of cerebellar Purkinje neurons.

Tonically active GABA - A receptors and electrical properties of cerebellar granule cells in the Ts65Dn mouse model of Down Syndrome

At one end of the neuroepithelium, a region developed that was positive for markers of progenitors of granule and deep cerebellar nuclei projection neurons and negative for Purkinje - cell markers, and whose origins could be traced to the rhombic lip zone of the cerebellar plate.

Knowing the function of cerebellar granule cells could lead to further important discoveries.

This painting of the cerebellar lobe is an example of his newer work.

Not exact matches

There are also some controlled trials associating wheat gluten with various disorders of the brain, including schizophrenia, autism and cerebellar ataxia (45, 46, 47).

According to research by James Prescott, a developmental neuropsychologist and cross cultural psychologist, «vestibular - cerebellar stimulation (which happens when we carry our babies) is the most important sensory system for the development of «basic trust» in the affectional bonding between mother and infant.

This study, reported in the February 2015 issue of Experimental Biology and Medicine, utilized cultured cerebellar granule neurons, one of the most widely used models to study neuronal death.

Compared to the brains of people without bipolar disorder, the researchers found that the MRI signal was elevated in the cerebral white matter and the cerebellar region of patients affected by bipolar disorder.

«Cerebellar interactions with the frontal cortex in cognitive processes has never been shown before in animal models,» says Parker, UI assistant professor of psychiatry and the first faculty hire of the new Iowa Neuroscience Institute.

Early experimental studies from Harvard in patients with schizophrenia suggest that cerebellar stimulation is safe and appears to improve some of the patients» cognitive abnormalities.

«The million dollar question is whether mutations of this gene also occur in humans with cerebellar ataxia,» says Becker, who is screening people with genetic forms of the condition to find out.

The movements of people with cerebellar ataxia are similar, but with notable differences.

The same neurons are destroyed in people with the disorder cerebellar ataxia, which causes unsteadiness and loss of coordination.

Their findings, «Repetitive Blast Exposure in Mice and Combat Veterans Causes Persistent Cerebellar Dysfunction,» published in Science Translational Medicine January 13 are helping to uncover the mysteries of how combat veterans have been injured by repetitive blast exposure.

The decreased blood flow in the following six regions of the brain were the most important in determining who had football related health trauma: anterior superior temporal lobes, rolandic operculum, insula, superior temporal poles, precuneus and, cerebellar vermis.

For decades neuroscientists have been building theories of brain function despite a near total lack of data on the most numerous neurons of all: cerebellar granule cells.

They also found evidence of reduced numbers of mitochondria and early mitochondrial deficiency in the cerebellar cortex.

Cerebellar granule cells form part of a brain circuit with a strikingly regular, almost crystalline, structure.

In humans, the cerebellum's extensive connectivity with the rest of the brain suggests it does far more than learn motor skills: it has been shown to have a part in both perception and cognition, with recent work linking cerebellar dysfunction to such complex diseases as schizophrenia and autism.