The human papillomavirus (HPV) causes genital warts and has been found in more than 90 %
of cervical tumors.
«The identification of HPV - negative endometrial - like tumors confirms that not all cervical cancers are related to HPV infection and that a small percentage
of cervical tumors may be due to strictly genetic or other factors,» noted Jean - Claude Zenklusen, Ph.D., director of NCI's TCGA program office.
Mathew Garnett, a cancer biologist at the Wellcome Trust Sanger Institute near Cambridge, UK, says that HeLa cells could prove useful for studying aspects of the biology
of cervical tumors, such as their response to cancer drugs.
Not exact matches
For example, HPV - inactive
tumors were 17 times more likely to contain disrupting TP53 gene mutations than HPV - active
cervical cancers, rendering unnecessary the expression
of the HPV E6 oncogene.
«It's very difficult to produce a mouse model
of a solid
tumor of the type we see in most women who are diagnosed with
cervical cancer.
Schwarz and her colleagues used three different drugs, alone and in combination, to deprive
cervical tumors of glucose and block downstream metabolic pathways that help protect cancer cells from building up toxic free radicals.
Now, researchers at Washington University School
of Medicine in St. Louis have shown that
cervical tumors that don't respond to radiation may be vulnerable to therapies that also attack the cancer's fuel supply.
In past imaging studies, my colleagues and I noticed that
cervical tumors that took up a lot
of glucose prior to radiation treatment tended to be more resistant to radiation therapy than other
tumors.
Genomic data from the HeLa cell line are also being released with the final version
of the paper as a result
of discussions between leaders
of the National Institutes
of Health (NIH) and relatives
of Henrietta Lacks, from whose
cervical tumor the original HeLa cell line was derived prior to her death in 1951.
The new study, a comprehensive analysis
of the genomes
of 178 primary
cervical cancers, found that over 70 percent
of the
tumors had genomic alterations in either one or both
of two important cell signaling pathways.
When analyzing the biology behind the molecular alterations in these
tumors, the researchers found that nearly three - quarters
of cervical cancers had genomic alterations in either one or both
of the PI3K / MAPK and TGF - beta signaling pathways, which may also provide targets for therapy.
«Studies have time and time again shown that brachytherapy is the most important part
of cervical cancer treatment, because it is essential to eradicating the
tumor,» said Timothy Showalter, MD, a radiation oncologist at UVA Cancer Center.
Sclareol inhibits cell proliferation and sensitizes cells to the antiproliferative effect
of bortezomib via upregulating the
tumor suppressor caveolin - 1 in
cervical cancer cells.
Researchers at Washington University School
of Medicine in St. Louis have shown that
cervical tumors that don't respond to radiation may be vulnerable to therapies that also attack the cancer's fuel supply.
In addition, broccoli prevents development
of breast,
cervical and prostate
tumors, and improves our liver function.
The chronically stressed mice had decreased immune function and experienced
tumor development significantly earlier than the non-stressed mice.16 Other mouse studies
of ovarian cancer showed that chronic stress resulted in increased cancer growth as well as increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and
cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risk.
Among this sample, females affected with HPV types - 16 / 18 are at most risk risk
of growing
cervical Tumors at sometime in their livetime.
Phytates have been shown to inhibit the growth
of human leukemia cells, colon cancer cells, both estrogen receptor - positive and negative breast cancer cells, voicebox cancer,
cervical cancer, prostate cancer, liver
tumors, pancreatic, melanoma, and muscle cancers.
Most
of the hyperthyroid cats without palpable
cervical nodules have thyroid
tumors (adenomas or carcinomas) that have become extremely large.
Estrogen is the hormone released during the estrus cycle has been reported as an important factor in the development
of various ovarian, uterinal and
cervical cat
tumors, which can be prevented by spaying cats when young; preferably before the first heat cycle.
Along with birth control, behavioral correction, and removal
of sexual frustration, various kinds
of reproductive tract problems such as ovarian and uterine
tumors, mammary gland
tumors and
cervical tumors can be prevented with feline spaying.