Eventually, Dietrich said, it should be possible to use this knowledge to check if animals to be used in challenge studies don't express a version of TRIMCyp that changes the outcome
of challenge experiments.
For example, restriction factors such as TRIM5 can restrict SIV replication and therefore affect the outcome
of challenge experiments.
It's also important to characterize the known restriction factors in NHPs, to be able to avoid variations in the outcome
of challenge experiments.
Not exact matches
The list has been carefully assembled for the sole purpose
of challenging Dipesh, who is an unwitting, but extremely good - natured, participant in my journalistic
experiment.
The great thing about this
challenge is that it inspires creativity and helps you to
experiment more with different types
of posts.
Del Ponte offers Fast Company a list
of lessons learned, including canceling most meetings, coordinating time zones, and ensuring local wi - fi is up to the
challenge the night before you start work, that anyone considering trying a similar
experiment should check out before they follow his lead.
At a time when investment firms are increasingly
experimenting with artificial intelligence and technology that can make trading decisions in a fraction
of a second, identifying disreputable sources has become a bigger
challenge.
Isaacson noted Da Vinci's «willingness to
challenge received wisdom would lead him to craft an empirical approach for understanding nature that foreshadowed the scientific method developed more than century later... His method was rooted in
experiment, curiosity, and the ability to marvel at phenomena that the rest
of us rarely pause to ponder after we've outgrown our wonder years».
In science, it's completely encouraged to
challenge prevailing wisdom, and see if you can disprove it with
experiments of your own.
We will continue by considering how Christianity both enriches and reorients the classical understanding
of politics and the distinctive questions and
challenges introduced by the American
experiment.
Whereas the dichotomy
of subject and object has been
challenged by
experiments in modern physics, a Cartesian dualism still provides the philosophical background
of modern molecular biology and, more recently, sociobiology.
Griffin further
challenges the assumption
of a «human monopoly on conscious thought» by noting that current
experiments indicate that animals produce «event related potentials» which resemble those produced by human beings.
At the conclusion
of his book, he
challenges his readers to a one - year
experiment of radical living where they pray more, read the Bible more, give more, serve more, and attend church (or small groups) more.
To meet the
challenge of our society, a church should
experiment with new patterns
of group life.
The new series will see the women «take part in a series
of entertaining tasks and hidden
experiments which will test their - and our - assumptions,
challenge gender stereotypes and reveal fascinating truths about what it is to be a woman - and man - in the 21st century».
There's a famous thought
experiment some Christians reference when discussing the
challenge of faith in the face
of doubt.
I am currently doing a 30 - day no - refined - sugar
challenge with a friend
of mine, and I wanted to
experiment with using alternative sweeteners in baking.
I enjoyed the
challenge of vegan baking and
experimenting with different substitutes.
Have been
experimenting with healthier cookies myself, because
of my 30 days
of health -
challenge on my blog!I'm so glad I found this site:)
This past Friday, Food52 posted a happiness
experiment on Instagram,
challenging their followers to write a list
of things that make them happy and tag it #happylist.
Developing these treats has been a fun
challenge and I'm getting a kick out
of experimenting with whole grain flours, natural sweeteners and alternative sources
of fat.
I am also interested in a mix
of recipes that are free
of other things for when I'm
experimenting with eliminating other items - soy can be particularly
challenging if you like asian flavors (or buying ANYTHING in the stores).
«As we continue to grow geographically and accept greater
challenges in
experimenting with new beers and styles, it is increasingly important to have someone like Kris on our team,» said Gary Fish Founder and owner
of Deschutes Brewery.
This cauliflower mash wasn't so much
of a
challenge as it was an
experiment.
(3) formation flexibility — it took 20 years for Wenger to return to a back 3 and now he can't seem to choose anything but that formation... the teams in the premiership and those we could face in the Europa will present vastly different tactics and we need to have a manager who can prepare this squad for this eventuality and have the fortitude to make the necessary adjustments throughout the season... I have seen nothing in the past 6 - 7 years to suggest that he is the man to take on this
challenge... I can't even remember when he changed formations when he would replace a small, pacy striker, like during the Walcott
experiment, with the lumbering Giroud...
of course this is exactly why there is no other manager in the world that plays more players out
of their natural positions (square peg in a round hole)
In any case as a Frenchman Wenger no doubt saw the
challenge of trying to win via various unorthodox
experiments as an intellectual
challenge.
As an
experiment, some
of us Folksy peeps decided to get involved with a listing
challenge, where we
challenged ourselves to list an item a day for a whole month, to see if it would improve views to our shops and products and hopefully generate some sales.
The sky's the limit, but games, science
experiments, construction toys, crafts, word play and imaginative role play are just a few
of the activities that will
challenge their brains while generating some laughs.
«The
challenge of parenting lies in finding the balance between nurturing, protecting, and guiding your child, and allowing her to explore,
experiment, and become an independent, unique person,» says California family therapist Jane Nelsen, author
of the Positive Discipline book series.
The eight - week program lasts from June 17, 2013 - August 12, 2013 and features a weekly
experiment or science
challenge that can easily be performed at home with kids
of all ages.
Each week throughout the summer, the Museum
of Science and Industry online kit will feature an
experiment or science
challenge that you can easily do at home with your kiddos (with some adult supervision).
«The
challenge of parenting lies in finding the balance between nurturing, protecting, and guiding your child, and allowing him to explore,
experiment, and become an independent, unique person,» says California family therapist Jane Nelsen, author
of the Positive Discipline book series.
One
of the first
challenges I encountered was that I couldn't fulfill part
of this
experiment.
The charity said this was «particularly concerning» as most
of these
experiments studied human diseases which do not exist in non-human primates, such as Parkinson's Disease, and this they suggested «significantly
challenges» the validity
of the tests.
One controversial
experiment recently
challenged this either / or scenario
of light by apparently detecting evidence
of both wave - and particle - like behaviour simultaneously.
Learning to communicate effectively is a lifelong
challenge, particularly for those who have chosen the translation
of ideas into tangible
experiments and actions that have an impact as a career path.
«Those
experiments will probably be quite
challenging because
of the high - frequency fields involved, but their outcome should finally tell us whether it is a radical - pair mechanism or not, and if it is, what the radicals are,» Hore says.
«I think the main message is that it would be very
challenging to detect either a short - term
experiment or a long - term deployment
of solar radiation management unless it was a pretty large signal,» she said.
To make matters more
challenging, Lappas decided at this early stage in the
experiment to search for patterns not only in the auditory cortex but in other areas
of the brain as well.
In a series
of experiments, the researchers found that 95 %
of mice vaccinated with the investigational cocktail were protected against a lethal
challenge with eight different influenza strains expressing seven different influenza A subtypes, compared to only 5 %
of mice who received mock vaccinations.
These
challenging experiments, carried out in a specialised lab, were designed to give insight into the fundamental structure and bonding properties
of elements in parts
of the periodic table that have not been studied in detail.
Instead they are encouraged to take the safer path, performing less
challenging, more routine
experiments in order to assemble the number
of publications necessary to take the next step in the career progression.
But for this one aspect
of the problem — the
challenge of providing precise and complete instructions for complicated and subtle procedures — a 21st century solution is at hand: Just train the camera on the bench to demonstrate how the
experiment is done, Pritsker says.
With each step in his laboratory
experiments, the
challenges got harder and more complicated, but because
of the rooks» understanding
of cause and effect, they produced solutions without resorting to trial and error.
While proof -
of - concept
experiments have been promising, there have been significant
challenges to printing highly integrated circuits using silver nanowires.
«It is a very
challenging experiment,» says John Rarity, an optical engineer at the University
of Bristol, UK, who was not involved in the work.
She «was dedicated to solv [ing]
challenging problems with the right combination
of creative planning and consequent and critical evaluation
of experiments,» he writes in an e-mail.
What we did was one simple set
of experiments, and it wasn't that technically
challenging either.
The staggering
challenge is to think
of a way to confirm the existence
of other universes when every conceivable
experiment or observation must be confined to our own.
At the famous Solvay conferences in 1927 and 1930, Einstein
challenged his friend Bohr, the chief proponent
of quantum mechanics, with thought
experiments meant to reveal logical contradictions in the theory.