Sentences with phrase «of channel function»

The Temple researchers recreated these mutated channels and showed that one resulted in a loss of channel function.

Not exact matches

Searching for Morgan Freeman, for example, will turn up a list of the actor's movies that are on Netflix, Crackle and Popcornflix, the three channels included in the search function to start with.

Hulu wouldn't say how many channels would be included in the service, whether or not there'll be more than one subscription tier, exactly how much content will be in its on - demand library, how many hours of cloud DVR will be included, what the search function looks like, a firm release date, or a price point besides «under $ 40.»

Slack allows for organised and searchable channels of communication sorted by type — projects, pitches, finance, HR — so everyone who needs information on a particular business function can access it quickly and easily.

«Many of the ones I've worked with mock org charts as old - school, even though their customers, investors, suppliers and channel partners can not function without clean organization charts that make it crystal clear who's in charge, accountable and responsible.»

My full report, with many more examples and a deep explanation of how and why channel synergies function, is available here.

As President and CEO of TD Ameritrade, he is primarily responsible for the oversight of the strategy and operations supporting the company's three client channels: Retail Investing, Trading and Institutional, along with additional responsibilities overseeing technology, operations and corporate functions.

I think the last rate cut also showed that the efficacy of the move was more limited than the BoC let on, with most of the net stimulus (through the FX channel) ultimately a function of the projected path for U.S. monetary policy.

The primary function of most teachers should be to stimulate and channel the students» dedication to make use of the abundant resources available through modern techniques of symbolic reproduction and distribution.

So for example, in my case and that of other persons whose minds dissociate when we engage in intense / deep spiritual practices like intense / deep prayer, meditation, fasting etc and we hear voices, hallucinate, see visions, experience thought insertions, automatic channelling just like a spirit medium as well as other psychic phenomena (clairvoyance etc), and the mind dissociation makes some persons mentally and emotionally unstable; our minds enter an altered state of consciousness just like those of the Buddhist monks but in our case the altered state of our brains results in psychotic and psychic symptoms being induced (interestingly, some persons who are ignorant of how the human brain functions chalk up these experiences to demonic attack)......... are these psychotic, psychic experiences which persons like myself experience a gift from God as well?

Parables function much as the Zen koan, or the tales of the dervishes, to tease the mind out of familiar channels and into a more right - brain view of things.

It has been estimated that 5 % to 10 % of infants who die from SIDS have novel mutations in the cardiac sodium or potassium channel genes that result in long QT syndrome as well as in other genes that regulate channel function.44 A recent report described important new molecular and functional evidence that implicates specific SCN5A (sodium channel gene) β subunits in SIDS pathogenesis.47 The identification of polymorphisms in genes pertinent to the embryologic origin of the autonomic nervous system in SIDS cases also lends support to the hypothesis that a genetic predisposition contributes to the etiology of SIDS.

And of course it contains a communications function, placing an RNC brand and magic «donate» button right on your desktop as well as opening up a new channel for direct messages from the Republican overlords.

Further studies in animal models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.

Therefore, Lambert - Eaton syndrome IgG reacts with voltage - dependent calcium channels and blocks their function, a phenomenon that can account for the presynaptic impairment characteristic of this disorder.

Vascular smooth muscle cells isolated from ERβ - deficient mice show multiple abnormalities of ion channel function.

One such drug — known as a Kv3 potassium channel modulator, in development by U.K. - based Autifony Therapeutics — may help improve neuron function in the part of the brain responsible for processing sounds.

The path that water takes through a channel is primarily a function of its volume and the channel's shape, slope, and the roughness of its surface.

«A docking site per calcium channel cluster: Researchers find link between morphology and function of synapses.»

Mutations that detrimentally affect the function of neuronal KV7 channels cause hyperexcitability syndromes such as benign familial neonatal seizures, early onset epileptic encephalopathy, and peripheral nerve hyperexcitability.

Proteins are fundamental macromolecules for life, with a diversity of functions, like acting as channels through cellular walls, catalysers, DNA benders, etc..

That work revealed that both mutations disrupted the function of the channel, making it unstable.

Most of the BMBF's support for stem cell research is channelled through two priority programmes: «Biological Replacement of Organ Functions» and «Tissue Engineering».

Synthetic transporters that can carry chloride through lipid - bilayer membranes have been developed that could potentially replace the function of faulty channels.

It is clear, however, that volatile anesthetics, which are more soluble in lipids than in water, primarily affect the function of ion channel and neurotransmitter receptor proteins in the membranes of nerve cells, which are lipid environments.

Co-author and Xin's supervisor Professor Phil Gale, Head of Chemistry at the University of Southampton, said: «We demonstrated the possibility to develop molecules to replace the function of chloride channels without disrupting pH homeostasis.

The invention of a less invasive implant device with many more channels that can interact with the brain would result in revolutionary improvements to brain - machine interfaces, including direct interfaces to the auditory cortex and the visual cortex, expanding dramatically the ways in which artificial systems can support brain function.

The induction of synapses required signaling through GABAA receptors and voltage-gated calcium channels and the newly formed synaptic structures rapidly gain functions.

A cryo — electron microscopy structure provides a framework for understanding function and disease mechanisms in a family of calcium channels.

Researchers used a drug called mexiletine, which restored the function of the channel and reversed the patient's symptoms of constipation and abdominal pain.

Intrigued, the doctor, a geneticist named Geoffrey Woods, eventually discovered two families who carried a genetic mutation that blocked the functioning of sodium channel 1.7.

«Moreover, we thought that this mobility was likely to be a function of the sediment - to - water ratio: More sediment would cause more rapid channel shifting.

«The water channels normally function to protect the brain, but in the case of traumatic injury or stroke they become a pathway of vulnerability that allows swelling.

The structure of synaptophysin suggests that the protein may function as a channel in the synaptic vesicle membrane, with the carboxyl terminus serving as a binding site for cellular factors.

«We know dysregulation of a protein enzyme called multifunctional CaM kinase II plays a role in disrupting sodium channel function in cardiac disease, but it was a matter of determining how this occurred and whether we could we prevent it for therapeutic benefit,» said Hund, an associate professor of biomedical engineering at The Ohio State University.

Prof. Henning Stahlberg's team at the Biozentrum of the University of Basel has now elucidated the full structure of a bacterial counterpart of this type of potassium channel, which has provided new insights into its functioning.

A study by Dr. Wendy Chung has identified six new mutations in a gene called KCNK3 that can interfere with the function of potassium channels and lead to pulmonary hypertension.

«We were surprised to learn that KCNK3 appears to play a role in the function of potassium channels in the pulmonary artery,» said Dr. Chung.

This is the first time scientists have combined heat and nanomagnetic particles to control cellular function, and the new technique, published online June 27 in Nature Nanotechnology, offers certain advantages over earlier and alternative methods of ion - channel manipulation.

The team found that the mutations alter the function of potassium channels by reducing the activity of these channels.

For example, the identification of highly specific and potent CFTR inhibitors has led to a number of studies examining the role of CFTR ion channel function in basic physiological processes.

The Tübingen researchers therefore tested the hypothesis that each of these 14 cell types represents one visual channel, each with its own function.

The function of these proton channels in other tissues is unknown.

But while studying taste perception, a group led by Emily Liman, USC Dornsife professor of biological sciences, discovered that Otop1 encodes a proton channel, providing hints as to how otopetrin1 contributes to inner ear function and balance.

For example, UT Southwestern's program was one of the first to use anti-lymphocyte antibodies to prevent and treat rejection; calcium channel blockers to improve the early function of transplanted kidneys; and molecular biology to better match donor kidneys with the patients who need them.

During sleep, a newly discovered network of water channels in the brain, called the glymphatic system, becomes active and functions as a waste disposal system, carrying toxins away which would otherwise accumulate and damage brain cells.

The channel - like property could have evolved, says Edwards, to meet the important need of moving large amounts of glutamate quickly, for while the other neurotransmitters are involved in modulating behaviors, such as mood, and therefore don't need to act with millisecond speed, glutamate functions by rapid - fire communication between closely placed nerve cells, and could require the fast action of the channel mechanism.

Recently, loss - and gain - of - function mutations in K2P channels have been directly linked to human pathologies (Birk Barel syndrome, familial migraine with aura, cardiac conduction disorder).

Their crisscrossing paths and collective efforts have nonetheless led to a clear - eyed understanding of how neurons — the brain's cellular building blocks — form and function and how ion - conducting channels control the flow of electrical signals through the nervous system.

Structures of water channels AQP0 and AQP4 were analyzed by electron crystallography and appear to play a role in cell adhesion in addition to water channel functions.