Sentences with phrase «of chimeric»

I wish I could have gotten subsumed in Annihilation's creepy cancer forest or at the very least been wowed by some of its chimeric creatures.

In addition, mixed lymphocyte cultures using the cells of the chimeric animals as responder cells to donor splenocytes failed to demonstrate any sensitization or clonal deletion of alloreactive T cells; i.e. T cell responses were identical to those of control animals (n = 4)(data not shown).

Although the T cells of chimeric animals responded to alloantigen, the response was similar to that of non-chimeric control animals, suggesting that these cells did not appear to lead to deletion of alloreactive T cells.

Timelapse of the internalisation of a chimeric doublet of cells expressing an actin marker (LifeAct) in different colours (snapshots taken every 15 min)

In a similar way, we used HV lacZ ES cells to ask whether the V+S + fraction would preferentially segregate to the outside of chimeric EBs.

Integration of iPS cells in the liver of chimeric mice.

One recent advance in cell - based therapies is the dramatic progress of chimeric antigen receptor T (CAR - T) cell therapies in the treatment of certain blood cancers.

Expression of Chimeric Receptor CD4zeta by Natural Killer Cells Derived from Human Pluripotent Stem Cells Improves In Vitro Activity but Does Not Enhance Suppression of HIV Infection In Vivo.

Anaplastic lymphoma kinase (ALK)-- positive anaplastic large cell lymphoma (ALCL) frequently carries the t (2; 5)(p23; q35) resulting in aberrant expression of chimeric nucleophosmin - ALK.

Second, Tat is eliminated through the addition of a chimeric 5» LTR containing a Tat - independent promoter.

Tisagenlecleucel is a one - time injection of chimeric antigen receptor (CAR) T cells manufactured for an individual patient using their own cells.

Expression Level of a Chimeric Kinase Governs Entry into Sporulation in Bacillus subtilis.

The SHIV - 89.6 3» construct encodes the HIV - 1 portions of the chimeric virus, cloned into the pBluescript II KS (+) vector (Stratagene).

He is the Principal Investigator of international Phase - II, randomized trial of Chimeric 14.18 or Temsirolimus in combination with Irinotecan / Temozolomide through Children's Oncology Group (COG).

Nonviral Minicircle Generation of Induced Pluripotent Stem Cells Compatible with Production of Chimeric Chickens.

In their latest study, Potash and colleagues describe the efficient and reproducible transmission of chimeric HIV from infected male mice to uninfected females via mating, providing the first report of HIV transmission by coitus in an animal model.

His laboratory has made several seminal contributions to the field of chimeric antigen receptors (CARs), from their conceptualization and optimization to their clinical translation for cancer immunotherapy.

«And given the state of the chimeric restriction endonuclease art prior to the patent's 1999 date, there are some serious doubts as to its validity.

More specifically, tisagenlecleucel is a type of chimeric antigen receptor T cell (CAR - T) therapy, a technique pioneered by immunologist Carl June and colleagues at the University of Pennsylvania.

A transformative cancer therapy based on modified immune cells has lured doctors, companies, and patients alike, but many are hitting a frustrating roadblock: generating enough of these chimeric antigen receptor (CAR)- T cells to meet surging demand.

Not exact matches

Kite Pharma, one of the companies chasing a new generation of cancer drugs called chimeric antigen receptor T - cell (CAR - T) therapies, announced a patient death in a clinical trial of its experimental KTE - C19.

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

US - based pharmaceutical company Gilead Sciences entered the chimeric antigen receptor (CAR) T - cell therapy business through its acquisition of Kite Pharma, and Australian biopharma company CSL Behring acquired US - based Calimmune, a company that develops clinical - stage gene therapy solutions.

In December 2016, the New England Journal of Medicine published a study demonstrating that a chimeric antigen receptor therapy (CAR - T) caused glioblastoma regression.

No. 4: CAR - T takes a backseat Research into chimeric antigen receptor T - cell (CAR - T) therapy has captured the attention of investors over the past two years, but safety risks could emerge as trial sizes increase, and that could help shift attention to other promising anti-cancer approaches, including NantKwest's (NASDAQ: NK) natural killer cell approach and soon - to - IPO Editas» CRISPR / Cas approach.

«A novel «chimeric» vaccine for dengue has been created by adding parts of the virus to a yellow fever vaccine»

We designed chimeric antigen receptor (CAR) T cells that specifically target podoplanin (PDPN), a key protein for the progression of solid tumors, including GBM.»

Whether the armamentarium of alternative vaccine candidates presently in the pipeline (including inactivated, live attenuated, chimeric, recombinant, subunit and DNA vaccines) will improve efficacy beyond 56 % remains to be established.

Researchers at The University of Texas MD Anderson Cancer Center developed a novel chimeric mouse model to test the combination therapy using immune checkpoint blockades with therapies targeting myeloid - derived suppressor cells (MDSCs).

«This chimeric role of employment / education affords us several concessions, including deferring student loans, increased time off... plus sick and holiday leave, decent benefits, the ability to pay into the UC retirement plan, and the flexibility of participating in lectures, seminar, conferences, and classes.»

After giving the cells a week to get used to each other, the scientists implanted the chimeric concoction into the protective tissue surrounding the kidneys of living mice.

They will examine the safety and feasibility of administering cancer - fighting chimeric antigen receptor (CAR) T cells that have been reprogrammed to target the CD22 protein expressed by some leukemia cells.

Kawaoka and his team, whose work has been accepted by Nature, created a chimeric virus with the hemagglutinin protein from H5N1 and the genes from the 2009 pandemic strain of H1N1.

In a 2009 study, University of Georgia at Athens cloning expert Steve Stice created 29 chimeric piglets by injecting pluripotent stem cells into pig embryos before implanting them into a surrogate womb.

The researchers are now looking at how ICOS signals can be altered to diminish autoimmune disorders and augmented for more effective vaccine development, and are beginning research on how ICOS signaling may benefit Chimeric Antigen Receptor - T cell (CAR - T) therapies, which involves engineering of patient's own immune cells to recognize and attack their cancers.

Over the past two years, investigators from the Perelman School of Medicine at the University of Pennsylvania have reported results from a human trial in GBM using chimeric antigen receptor (CAR) T cell therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.

Extracts from the brains of FFI patients transmitted disease to transgenic mice expressing a chimeric human - mouse PrP gene about 200 days after inoculation and induced formation of the 19 - kilodalton PrPSc fragment, whereas extracts from the brains of familial and sporadic Creutzfeldt - Jakob disease patients produced the 21 - kilodalton PrPSc fragment in these mice.

«NYGC is thrilled to have this work be our first published example of the explosive power of collaborations between deeply invested biologists like those in the Simon lab including Elana Simon, and thoughtful bioinformatics scientists like Nicolas Robine and NYGC team, who worked together so effectively with the tools of genomic sequencing and analysis to discover this new chimeric protein and cancer target,» says Robert Darnell, head of Rockefeller's Laboratory of Molecular Neuro - Oncology, HHMI investigator, and president and scientific director of NYGC.

Here, we show that in the antibody - mediated autoimmune disease pemphigus vulgaris (PV), autoantigen - based chimeric immunoreceptors can direct T cells to kill autoreactive B lymphocytes through the specificity of the B cell receptor (BCR).

The engineered cells contain an antibody - like protein known as a chimeric antigen receptor (CAR), which is designed to bind to a protein called CD19 found on the surface of B cells, including the cancerous B cells that characterize several types of leukemia.

The modified T cells contain a protein known as a chimeric antigen receptor (CAR), which is designed to target the CD19 protein found on the surface of B cells, including the cancerous B cells that characterize several types of leukemia and lymphoma.

The team developed a «chimeric autoantibody receptor,» or CAAR, that displays fragments of the autoantigen Dsg3 — the same fragments to which PV - causing antibodies and their B cells typically bind, as Payne's laboratory and others have shown in prior studies.

This is a schematic of how a «chimeric autoantibody receptor,» or CAAR, that displays fragments of the autoantigen Dsg3 helps fight an autoimmune disease called pemphigus vulgaris, a condition in which a patient's own immune cells attack Dsg3, which normally adheres skin cells.

Biologist Stuart Newman of the New York Medical College in Valhalla is trying to get a patent on a «humanzee» — a chimeric animal made from human and chimpanzee embryos.

Those findings are among results of six studies of investigational chimeric antigen receptor (CAR) T cells for both adult and pediatric leukemias, adult lymphomas, and ovarian cancer which will be presented during the 2016 American Society of Clinical Oncology Annual Meeting.

North says his group has already generated a human chimeric form of MAG - 1 that is equally effective as mouse MAG - 1, and they are now generating a humanized form for use in patients.

The work stems from an earlier collaboration between Potash and David J. Volsky (also from Columbia University); they established a chimeric HIV clone with a genetic modification that allows the virus to propagate in rodents instead of humans.

Dr. June: I mentioned that CAR is a chimeric molecule that has both the binding domain made of an antibody and a signaling engine that's inside the cell.

Zelig Eshhar and colleagues first use the T - body approach, employing chimeric receptors composed of an antibody recognition unit linked to T cell activation domains, to redirect T cells to recognize and attack tumor cells.

In the proposed project, Dr. Lampi Hermanson will produce NK cells from stem cells, inserting a chimeric antigen receptor (CAR) with the capacity to recognize mesothelin cells, which is expressed in 70 % of ovarian cancer patients.