Sentences with phrase «of cholesterol ester»

The observation that HDL cholesterol did not increase in ApoC - III — treated mice would seem to support an LPL - independent mechanism as well, although the absence of cholesterol ester transfer protein in mice confounds this finding.

«For example, HDL and LDL themselves are comprised of hundreds of molecular species of cholesterol esters and triglycerides.

Not exact matches

The findings make evacetrapib the third failure in a class of drugs known as cholesteryl ester transfer protein (CETP) inhibitors, which are designed to disrupt the natural process by which HDL cholesterol is converted into LDL cholesterol in the body.

These studies will investigate the consequences of ApoF knockdown on cholesterol disposition in an animal model, quantify ApoF levels in human subjects and identify lipoprotein properties that cause ApoF to bind and subsequently inhibit cholesteryl ester transfer protein activity, and investigate the molecular mechanisms controlling ApoF gene expression.

ApoF is a regulator of cholesteryl ester transfer protein, which in turn is a major regulator of the distribution of cholesterol between low and high density lipoproteins.

After adjustment for intake of meat, beer, potatoes, root crops, and vegetables the associations were weakened, but significant inverse associations remained between 15:0 in serum cholesterol esters and body weight and BMI (data not shown).

Both ApoC - III — depleted TRLs and ApoC - III — bearing TRLs had equal amounts of TGs, free cholesterol, cholesteryl esters, and [3H] retinol when normalized to protein (Supplemental Figure 7).

Nevertheless, when the fatty acids in their serum cholesterol esters were analyzed, omega - 3 (EPA and DHA) levels were high and, more importantly, the omega - 6 / omega - 3 ratio was very low, owing to the low intake of linoleic acid (an omega - 6 fatty acid present in the oil of most seeds and nuts, who decreases the EPA and DHA status).

The chemical analysis of the atheroma shows that the fatty acids from the cholesterol esters are 74 % unsaturated (41 % is polyunsaturated) and only 24 % are saturated.