Sentences with phrase «of cholesteryl»

ApoF is a regulator of cholesteryl ester transfer protein, which in turn is a major regulator of the distribution of cholesterol between low and high density lipoproteins.

Increased SQLE expression promotes the biosynthesis of cholesteryl ester, which induces NAFLD - HCC cell growth.

Not exact matches

Suppression of tumor growth by terbinafine is associated with decreased cholesteryl ester concentrations, restoration of PTEN expression, and inhibition of AKT - mTOR, consistent with blockade of SQLE function.

The findings make evacetrapib the third failure in a class of drugs known as cholesteryl ester transfer protein (CETP) inhibitors, which are designed to disrupt the natural process by which HDL cholesterol is converted into LDL cholesterol in the body.

In addition, hepatic lipidomic analyses revealed decreases in several species of triacylglycerols, phospholipids and cholesteryl esters.

These studies will investigate the consequences of ApoF knockdown on cholesterol disposition in an animal model, quantify ApoF levels in human subjects and identify lipoprotein properties that cause ApoF to bind and subsequently inhibit cholesteryl ester transfer protein activity, and investigate the molecular mechanisms controlling ApoF gene expression.

Both ApoC - III — depleted TRLs and ApoC - III — bearing TRLs had equal amounts of TGs, free cholesterol, cholesteryl esters, and [3H] retinol when normalized to protein (Supplemental Figure 7).

In these studies, atherosclerosis was associated with the diet - induced enrichment of LDL with cholesteryl oleate.

Notably, in humans, the risk of stroke has been related to both the saturated and monounsaturated fatty acid content of plasma cholesteryl esters, which further supports the possibility that the dietary intake of these fatty acids may influence CVD risk by altering cholesteryl ester composition (87).