Sentences with phrase «of chondrocytes»

The results showed that, when applied, a long - term inhibition of Rho - kinase signaling increased the expressions of chondrocyte - specific genes and differentiation markers in human chondrosarcoma 2/8 cells.

Elisseeff J, McIntosh W, Anseth K, Riley S, Ragan P, Langer R. «Photoencapsulation of chondrocytes in poly (ethylene oxide)- based semi - interpenetrating networks.»

Previously, it has been suggested that S100A1 and S100B proteins can act as markers of chondrocyte differentiation status, although the concept is still not commonly adopted so far.

Dr Wael Kafienah, lead author from the University's School of Cellular and Molecular Medicine, said: «We were surprised with this finding, the blend seems to provide complex chemical and mechanical cues that induce stem cell differentiation into preliminary form of chondrocytes without need for biochemical induction using expensive soluble differentiation factors.

The findings suggest that reductions in the number of cartilage - producing cells, and greater risk for osteoarthritis, may be driven not just by lower adenosine levels but also by lower levels of the protein on the surface of chondrocytes designed to receive and pass on adenosine's signal.

«This kind of markers can be useful to monitor responses during chondrocyte in vitro culturing, but also be applicable to monitor status of the chondrocytes during the different kinds of cartilage therapies.

This finding offers new evidence of the applicability of S100A1 and S100B as markers of chondrocyte phenotype,» says Juha Piltti.

A 3D printer can construct scaffolding, which can be covered in a mixture of chondrocytes and collagen, which then grows into cartilage.

Molecules known to affect FGFR3 signaling and / or the metabolism of chondrocytes, the cells responsible for growing cartilage, were identified as good candidates.

Proteomics of chondrocytes with special reference to phosphorylation changes of proteins in stretched human chondrosarcoma cells.

Together they studied the efficacy of chondrocyte implantion to treat osteoarthritis and osteochondritis dissecans (OCD) lesions in horses.

These substances are well known for promoting the increased production of chondrocytes or the cells that make up the cartilage found in the ends of adjoining bones.

His studies also show that glucosamine reduces inflammation and pain in animals with arthritis, while enhancing the beneficial activity of chondrocytes, the cells that play a major role in rebuilding cartilage.

Excessive biomechanical loading of the inadequately supported epiphyseal articular cartilage leads to secondary disturbances in the nutrition, metabolism, function and viability of the chondrocytes in the developing joint surface.

A short - term inhibition of Rho - kinase failed to induce extracellular matrix production in fibroblasts or in HCS - 2 / 8 cells, while its long - term exposure increased the expressions of chondrocyte - specific genes and differentiation markers, and also promoted the synthesis of sulfated glycosaminoglycans by chondrocytic cells.

The team treated blends of silk and cellulose for use as a tiny scaffold that allows adult connective tissue stem cells to form into preliminary form of chondrocytes — the cells that make healthy tissue cartilage — and secrete extracellular matrix similar to natural cartilage.

In children with achondroplasia, a genetic flaw causes a receptor on the surface of these chondrocytes to be hyperactive.

Despite the marked changes in the cell behavior, ROCKi was not able to induce the expression of the chondrocyte - specific genes, such as procollagen α1 (II) and aggrecan.