Sentences with phrase «of chronic hypoxia»

To study the effect of hypoxia / reoxygenation cycles on breast cancer, we exposed two metastatic human breast cancer cell lines (MDA - MB 231 and BCM2) to cycles of chronic hypoxia and nutrient deprivation.

Here, we show that a non-adherent, stem - like, and metastatic CSC - enriched subpopulation could be isolated by exposing human metastatic breast cancer cell lines to cycles of chronic hypoxia followed by reoxygenation.

Not exact matches

Published in Nature Medicine on May 1, 2017, the study demonstrates chronic ischemic hypoxia (lack of blood and oxygen) after spinal cord injury and how blood flow plays a key role in the cause and treatment of motor disorders.

Fat tissue in obese people is believed to exist in a chronic state of mild hypoxia because the small blood vessels are unable to supply sufficient oxygen to fat tissue.

The effects of chronic prenatal hypoxia on the fetal and adult offspring cardiovascular system are prevented by maternal treatment with vitamin C during pregnancy.

Therefore, the primary novelty of the discoveries reported here is that programming by prenatal chronic hypoxia of cardiac and vascular dysfunction in adulthood follows the induction of oxidative stress in the fetal heart and vasculature, and that cardiac and endothelial dysfunction in adulthood can both be prevented by maternal treatment with antioxidants during pregnancy.

The aims are to study the adaptive response and damage / repair mechanisms of the foetus and newborn to a poor pre - and perinatal environment as during severe preeclampsia (asphyxia, hypoxia, growth restriction), chronic intrauterine infections and perinatal insults related to hypoxia and inflammation.

Furthermore, susceptibility of genomic instability can vary after acute or chronic exposure to hypoxia followed by reoxygenation [23].

However, chronic exposure of cells to hypoxia induces disassembly of the replisome, preventing replication restart after reoxygenation [23].

We showed that a chronic oxidative stress accelerates aging through accumulation of HIF (Hypoxia - Inducible Factor) and modulation of insulin signaling (Gerald, Cell, 2004; Laurent, Cell Metabolism, 2008).

But veterinarians who believe that brachycephalic dogs suffer more from heart issues suggest that a deficiency of oxygen over time (chronic hypoxia) causes blood channels in the lungs to narrow (pulmonary vasoconstriction) which then leads to increased blood pressure within the heart (pulmonary hypertension), a known risk for heart failure.

Canine: Determination and Mapping of Acute and Chronic Hypoxia in Canine Tumors D08CA - 077, Marlene L. Hauck, Grant Amount: $ 113,230

Dr. Hauk's research will define the genes associated with chronic and intermittent hypoxia to give clinicians a tool — based on the type of hypoxia — to better tailor therapy for individual patients.