[5] The latest WSAVA Vaccination Guidelines for New Puppy Owners (published in May 2013) advise «the
presence of circulating antibodies indicates that the dog is immune, and revaccination (with core vaccines) is not required».
Puppies born to dogs that were vaccinated just prior to mating usually have high
levels of circulating antibodies so that they do best when their first vaccine is closer to 12 weeks of age.
She admits that it «wasn't very easy» to convince her veterinarian that, in lieu of vaccinations, Casey should receive an antibody titer test to determine whether she had what vaccination experts regard as a «protective level»
of circulating antibodies from past vaccinations.
Therefore, in patients where biological infliximab is ineffective due to the
presence of circulating antibodies, switching to its biosimilar will lead to the same problems,» Dr Nagore concluded.
The shots must be given to puppies at a time when the
level of circulating antibody that they received from their mothers is in decline or the vaccine's effects are neutralized.