Immunicon Corporation (PI)($ 40,000 Total) 2001 - 2002 Longitudinal enumeration
of circulating tumor cells in patients with metastatic breast carcinoma
Among patients with non-small cell lung cancer (NSCLC) fueled by ALK gene alterations who were being treated with crizotinib (Xalkori), a decrease in the
number of circulating tumor cells (CTCs) harboring increased copies of the ALK gene over the first two months of treatment was associated with increased progression - free survival.
«Despite the
identification of circulating tumor cells (CTCs) and cell - free DNA (cfDNA) as biomarkers capable of providing clinically relevant information in cancer patients, at present their identification is not routinely used in clinical practice,» explains Silvia Morbelli, MD, PhD, of the IRCCS San Martino — IST National Cancer Research Institute and University of Genoa in Genoa, Italy.
Researchers have found a
group of circulating tumor cells in prostate cancer patient blood samples which are linked to the spread of the disease, according to new research presented at the National Cancer Research Institute (NCRI) Cancer Conference in Liverpool.
«The method we describe in this paper is a step forward in the detection and
isolation of circulating tumor cells in the body,» said Subra Suresh, one of the study's authors and president of Carnegie Mellon University.
Microvascular endothelial cells play a critical role in tumor progression and metastasis by forming capillary networks that encourage tumor growth and by promoting the
attachment of circulating tumor cells to the vascular wall of distant tissues.
Bone marrow aspiration being somehow invasive, we then investigated whether the
detection of circulating tumor cells (CTC) in the blood could be used as a biomarker of early tumor relapse or progression.
We conducted a meta - analysis in nonmetastatic breast cancer patients treated by neoadjuvant chemotherapy (NCT) to assess the clinical
validity of circulating tumor cell (CTC) detection as a prognostic marker.
One of these very exciting projects is barcoding of genes and their functional products in single
cells of circulating tumor cells, CTCs», said Afshin Ahmadian.