Sentences with phrase «of cisplatin»

Only a low dose of cisplatin gets into the blood stream.

RNA - sequencing dissects the transcriptome of polyploid cancer cells that are resistant to combined treatments of cisplatin with paclitaxel and docetaxel.

Moreover, use of the gel led to significantly lower levels of cisplatin in liver tissue 5 centimetres away from the cancer, and in the kidneys.

The chemotherapeutic effect of cisplatin combined with the radiosensitizing effect of gold nanoparticles resulted in enhanced synergy enabling a more effective cellular damage.

By cutting gelsolin down to a specific fragment and putting it into chemo - resistant cancer cells, the international team discovered they could make these cells susceptible to the cancer - killing effects of cisplatin.

«The robust protection conferred by one - time local delivery of kenpaullone suggests that CDK2 inhibitors may transform the clinical prevention and treatment of cisplatin - and noise - induced hearing loss in patients,» Zuo says.

This outcome compares to the standard alternative — the combination of cisplatin with the chemotherapy drug paclitaxel, which showed a response rate against the tumor of 29 percent for up to 6 months and an overall survival of 13 months.

They found that adaptive immunity is reversely associated with resistance of cisplatin, the drug used for ovarian cancer.

In A427 cells, PARP cleavage was detected in STAT6 DN cells at 50 μM of cisplatin compared to control cells at 100 μM, whereas in H2122, it was 250 μM versus 500 μM.

In the case of cisplatin - induced hearing loss, kenpaullone appears to protect hair cells by preventing CDK2 from stimulating the production of toxic reactive oxygen species from the cells» mitochondria.

«Given that pemetrexed combined with cisplatin may be less toxic than and as active as cisplatin plus paclitaxel and that it can be combined with bevacizumab, investigating the comparison of cisplatin - pemetrexed plus bevacizumab with cisplatin - paclitaxel plus bevacizumab would be the next appropriate step,» said Dr. Miller, who holds the Amy and Vernon E. Faulconer Distinguished Chair in Medical Science and the Dallas Foundation Chair in Gynecologic Oncology.

The multicentre trial included 153 patients with surgically - treatable malignant pleural mesothelioma, who were first treated with three chemotherapy cycles of cisplatin and pemetrexed, followed by surgical removal of affected lung tissue, with the goal of complete removal of the cancerous areas of lung.

The derivation cohort included 493 patients with OPSCC, a known tumor p16 status, and a smoking history measured in pack - years, who were randomized into two clinical trials: NRG Oncology / RTOG 0129, a phase 3 trial that evaluated standard fractionated (SFX) vs. accelerated fractionated (AFX) radiotherapy with cisplatin; and, NRG Oncology / RTOG 0522, a phase 3 trial that evaluated the addition of cisplatin to AFX radiotherapy and concurrent cisplatin.

The history of cisplatin, the drug that is still the gold — or should that be platinum?

This study examined the expression levels of cisplatin transporter molecules and cisplatin - DNA repair activity across a 24 - hour cycle in mouse kidneys and livers.

Sorenseon DN, Dakup PP, Gaddameedhi S. Chronopharmacology of cisplatin: Role of the circadian rhythm in modulating the cisplatin transporters levels [published online April 2016].

A Randomized Phase 2 Trial of Cisplatin / Gemcitabine with or without VX - 970 in Metastatic Urothelial Carcinoma

Phase I / II Study of Cisplatin plus Romidepsin and Nivolumab in Metastatic Triple Negative Breast Cancer or BRCA Mutation - Associated Locally Recurrent or Metastatic Breast Cancer

Clinical Practice Recommendations for the Management and Prevention of Cisplatin - Induced Hearing Loss Using Pharmacogenetic Markers

The study included 44 patients in the sunitinib group and 41 patients in the placebo group; all received a chemotherapy regimen of cisplatin or carboplatin and etoposide after enrollment but prior to randomization.

Short Research Communication The Factors Reducing Relative Dose Intensity of Cisplatin and Vinorelbine as Adjuvant Chemotherapy in Patients with Non-Small Cell Lung Cancer Ryo Inose, Katsuyuki Takahashi, Naruo Yoshimura, Tomoya Kawaguchi, Mitsutaka Takada, Katsuya Nagayama Oncomedicine 2018; 3: 9 - 14.

Research Paper Yangyin Fuzheng Decoction enhances anti-tumor efficacy of cisplatin on lung cancer Dongmei Wei, Lin Wang, Yuhan Chen, Gang Yin, Mei Jiang, Rui Liu, Hong Chen, Xiyuan Sun J. Cancer 2018; 9 (9): 1568 - 1574.

Evaluation of cisplatin combined with piroxicam for the treatment of oral malignant melanoma and oral squamous cell carcinoma in dogs.

This high local dose of cisplatin will kill cancer cells remaining in the leg after limb sparing surgery.

Again different protocols are used at different facilities but most use some combination of cisplatin or carboplatin along with doxorubicin.

Thirty minutes after injecting the gel and cisplatin into the tumours, the levels of cisplatin were five times higher inside the tumour than when the drug was injected without the gel.

High doses of Cisplatin or Piorxicam can be used in this regard, as per the veterinarian's prescription.