Sentences with phrase «of clinical grade»

His lab has pioneered the generation of clinical grade induced pluripotent stem (iPS) cells using non-viral reprogramming methods such as direct delivery of reprogrammed proteins and novel episomal methods, and has recently identified novel mechanisms underlying metabolic reprogramming during human induced pluripotency.

The development of these clinical grade stem cells, the release notes, «removes a significant barrier in the development of cell - based therapies.»

While this strategy represents an efficient strategy for the production of MKs, adaption for clinical applications requires the elimination of all animal products and the use of clinical grade reagent.

Blood describes a diverse group of cells that includes those that carry oxygen, heal wounds, and fight off infection, and the production of clinical grade blood has remained a major goal of reprogramming science.

British midwifery began experiencing problems in the 1980s, after the introduction of clinical grading forced many to quit altogether.

Not exact matches

Widespread adoption «requires a very rigorous economic and clinical analysis,» says Armen Bakirtzian, CEO and co-founder of Intellijoint Surgical, which makes a miniature surgical - grade tracking system that allows surgeons to select and align implants more accurately.

«What set Flatiron apart was that it was able to create regulatory grade, real - world data,» O'Day tells Fortune — data that O'Day claims is so well curated, that it «could have theoretically replaced the «control» arm» of one of Roche's own clinical trials for the cancer immunotherapy drug Tecentriq.

Brendan Kennedy, the cofounder of Privateer Holdings, which owns various marijuana companies like Marley Natural and Canadian pharmaceutical - grade cannabis producer Tilray, explains how Tilray is already exporting marijuana to countries like Croatia and Australia for use in clinical trials.

While this is not really a surprise, since similar research and trials with wounds on people has shown the healing benefits of using medical grade manuka honey, this is the first time a clinical trial has been done on horses.

Concussions result in a graded set of clinical symptoms that may or may not involved loss of consciousness (LOC).

The alleged lack of scientific studies and the amount of clinical judgment involved in concussion management, and the lack of uananimity, either about grading the severity of concussions or in return to play guidelines, while it complicates our efforts to educate parents on concussions, should not be used as an excuse to do nothing.

Playability Toys, a leading maker of therapeutic toys and apps that enhance and improve the lives of children and their families, today announced it has officially launched its ground - breaking Nurture Smart Mobile — the first and only clinical grade crib mobile of its kind.

Check out clinical psychologist Edward Christophersen's list of the skills your grade - schooler should have in order to travel a...

You have to do a certain volume of clinical activity, and you have certain scores and grades from your patients.

They gauged aggressiveness using the results of the patients» prostate cancer - specific antigen, or PSA, tests, as well as the clinical stage of their cancer and Gleason grade.

One of the key innovations was the development of a black flexible material that included a mesh of carbon nanotubes enclosed within clinical grade silicone precisely applied to an optical fibre.

Although the mix - up is being examined, the center has halted supplies of some of its iPS cells to researchers across Japan; the error also set back by a few years a CiRA project to produce clinical - grade platelets from iPS cells.

Women who have polycystic ovary syndrome — the most common hormone disorder in women of reproductive age — are more likely to experience chronic low - grade inflammation during pregnancy than counterparts who do not have the condition, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

«What has to happen is tuning of the software and the perfecting of the technology to be able to make a clinical grade genome.

In clinical samples of high - grade gliomas from patients, the expression levels of both FOXD1 and ALDH1A3 were inversely correlated with disease progression — gliomas with high levels were more rapidly fatal than were gliomas with low levels.

Many of these cognitive and behavioural therapies (of which guided graded exercise self - help is an example) can be very helpful to patients and will be used more frequently in routine clinical practice only when we abandon the notion that these therapies need to be administered through face - to - face contact with highly trained therapists.»

This is the first JTFPP guideline that was developed using a GRADE (Grading of Recommendations, Assessment, Development and Evaluations) methodology, a very rigorous, systematic, evidence - based approach to making clinical recommendations.

To make «clinical - grade» cells, scientists produced them without the use of any of the animal cells or products typically needed, and did so under certified manufacturing conditions.

Much of the money went into infrastructure that will enable the creation of additional clinical - grade cell lines, he says.

Moreover, cell lines vary in their ability to make different tissues, such as heart muscle or cartilage, so a suite of clinical - grade lines is needed, Braude says.

Elsewhere in the United Kingdom, researchers at the University of Sheffield and Roslin Cells, a company based in Edinburgh, are also establishing clinical - grade lines.

The next steps for this vaccine are to produce a clinical grade lot and conduct a phase 1 study of safety and immunogenicity in infants, Moore says.

Approximately equal numbers of women and men enter and graduate from medical school in the United States and United Kingdom.1 2 In northern and eastern European countries such as Russia, Finland, Hungary, and Serbia, women account for more than 50 % of the active physicians3; in the United Kingdom and United States, they represent 47 % and 33 % respectively.4 5 Even in Japan, the nation in the Organisation for Economic Co-operation and Development with the lowest percentage of female physicians, representation doubled between 1986 and 2012.3 6 However, progress in academic medicine continues to lag, with women accounting for less than 30 % of clinical faculty overall and for less than 20 % of those at the highest grade or in leadership positions.7 - 9 Understanding the extent to which this underrepresentation affects high impact research is critical because of the implicit bias it introduces to the research agenda, influencing future clinical practice.10 11 Given the importance of publication for tenure and promotion, 12 women's publication in high impact journals also provides insights into the degree to which the gender gap can be expected to close.

The impact of Ex Vivo clinical grade activation protocols on human T - cell phenotype and function for the generation of genetically modified cells for adoptive cell transfer therapy.

To develop criteria, procedures and protocols for reproducible, safe and large - scale manufacture of stem cells and their progeny to clinical grade standard;

His clinical practice includes the entire spectrum of brain tumors including low - grade gliomas, malignant gliomas, metastatic brain tumors, and benign tumors such as meningiomas, and acoustic neuromas.

The CNAG - CRG has an essential role, carrying out clinical grade sequence analysis and piloting the development of a clinical - genomics platform for cancer and rare disease diagnostics for the Catalan Health Service.

If successful, this method will be tested at scale by an industrial partner who will generate clinical - grade material for a Phase 1 trial at the end of this five - year grant.

St. Jude has also developed exclusive manufacturing processes to produce large amounts of clinical - grade genetic material for clinical trials.

But, he notes that it will be necessary to perform well - designed clinical trials that test the safety and efficacy of high - grade NMN in humans before making the leap to using NMN (or perhaps its analogs) as pharmacotherapeutic agents.

CONCLUSIONS: These results have led to the decision to produce GMP - grade c11 - 1F4 for a Phase I / II clinical trial in patients with primary (AL) amyloidosis where the effectiveness of the reagent could be determined.

«Determining prognosis involves a range of other clinical factors, including tumor size and grade, the degree to which the cancer has spread, and the age and race of the patient.

Unfortunately, the standard tools for assessing risk of metastasis — such as the size of the tumor, its grade, the presence of estrogen receptors and the proportion of dividing cells — are «insufficient,» note the authors, «for clinical decision making.»

In both projects the CNAG - CRG has an essential role, carrying out clinical grade sequence analysis and piloting the development of a clinical - genomics platform for cancer and rare disease diagnostics for the Catalan Health Service, based on the RD - Connect platform developed at CNAG - CRG in the framework of an EU project.

First, in 2001, CRI formed a partnership with the Ludwig Institute for Cancer Research to develop the Cancer Vaccine Collaborative (CVC)-- a centralized, academic, global network of clinical trial sites, immune monitoring laboratories, and clinic - grade, GMP cancer vaccine production facilities.

In both projects the CNAG - CRG has an essential role, carrying out clinical grade sequence analysis and piloting the development of a clinical - genomics platform for cancer and rare disease diagnostics.

Review of «Footprint free human iPSCs from articular cartilage with redifferentiation capacity - a first step towards a clinical grade cell source» from Stem Cell Translational Medicine by Stuart P. Atkinson

He was particularly impressed with clinical studies that suggested that 10 grams of pharmaceutical grade collagen hydrolysate per day were enough to reduce pain in patients with osteoarthrisis of the knee or hip and that gelatin held a significant treatment advantage over the placebo.

The American Society of Clinical Oncology / American Urological Association 2008 Clinical Practice Guideline states: «Men who are taking 5 - ARIs for benign conditions such as lower urinary tract symptoms (LUTS) may benefit from... understanding that the improvement of LUTS relief should be weighed with the potential risks of high - grade prostate cancer from 5 - ARIs.»

Clinical nutrition is the therapeutic utilization of foods and pharmaceutical grade supplements to maintain optimal health and has been used for various types of illness.

[107] Establishing guidelines to assess safety and efficacy of botanical supplement products, the European Medicines Agency provided criteria for evaluating and grading the quality of clinical research in preparing monographs about herbal supplements.

Given the broad range of students included under Kansas's K - 12 special education license, it is important that the state's clinical practice requirements include experience in multiple grade levels.

This study was funded by the Children's Foundation and involved measuring the relationship between brain processing of speech sounds, nonverbal emotion recognition, and other social - emotional comprehension skills in both typically - developing children and children with a range of clinical diagnoses (e.g., ASD, ADHD, reading disorders, language disorders) who are in grades K - 3.

Only addressing the clinical side of grading.

My appointment to the State of Connecticut Task Force for helping struggling readers in Connecticut grades four to nine is beneficial to our department particularly in informing our curriculum and instruction in the clinical sequence — diagnosis and remediation in reading and language arts.