«This could be a very promising way to decrease the burden of living with food allergies,» said Chinthrajah, director
of clinical translational research at Stanford's Center for Allergy and Asthma Research.
«RNAi therapies are a unique approach to cancer treatment as they have the potential to «turn off» the genes» coding for proteins involved in cancer cell division,» said Ramesh K. Ramanathan, M.D., medical director of the Virginia G. Piper Cancer Center Clinical Trials Program at Scottsdale Healthcare and deputy director
of the Clinical Translational Research Division of the Translational Genomics Research Institute (TGen) in Phoenix, Ariz. «Using a lipid nanoparticle, the RNAi drug can be delivered to a cancer cell to block the expression of specific proteins involved in tumor growth.»
Not exact matches
CTI - 1601 was invented by R. Mark Payne, MD, professor
of Pediatric Cardiology at Indiana University School
of Medicine and director
of the
Translational Research Training Program
of Indiana
Clinical Translational Sciences Institute.
A $ 291 million combined facility includes the Gates Vascular Institute and University
of Buffalo's
Clinical and
Translational Research Center.
More than 40 years after those early experiments, Jackson has risen to become the associate dean for
clinical research and director of Ohio State University (OSU) Medical Center's Center for Clinical and Translational Science
clinical research and director
of Ohio State University (OSU) Medical Center's Center for
Clinical and Translational Science
Clinical and
Translational Science (CCTS).
«The most common time there is conflict
of interest is not with inventorship,» says Harry Greenberg, senior associate dean for
research at the Stanford University School of Medicine in Palo Alto, California, and director of the Stanford Center for Clinical and Translational Education and R
research at the Stanford University School
of Medicine in Palo Alto, California, and director
of the Stanford Center for
Clinical and
Translational Education and
ResearchResearch.
«In Portugal, we don't have a lot
of... companies that do
translational research, so the goal was really to apply our knowledge to the
clinical field and to be able to establish a bridge,» Outeiro says.
That priority influences the design
of research questions, Weng notes, and encourages scientists involved in basic
research, including postdocs, to participate in «very dynamic» collaborations with
translational and
clinical groups.
The lead author
of the study was Jacqueline French, MD, professor
of neurology and director
of Translational Research &
Clinical Trials Epilepsy at NYU Langone's Comprehensive Epilepsy Center.
With support from Ohio State's Center for
Clinical and
Translational Science (CCTS), Dr. Bonny's
research team was able to comb through past
research to identify the top 30 nutrients that were most likely to influence the growth
of fat tissue in a low - estrogen environment.
D. degrees train individuals in
clinical and basic
research, but
translational research programs strive to integrate these two sides
of medical science by connecting people and building networks.
In either case, the goal is becoming competent to interpret, evaluate, and discuss different types
of research, rather than conducting it all yourself, says Doris Rubio, professor
of medicine, biostatistics, nursing, and
clinical and
translational science at the University
of Pittsburgh.
The efficient movement
of basic science discoveries into
clinical applications — often described as «bench to bedside» work — is the goal
of translational research.
«I enjoy the
clinical work I do now,» she says, «but ultimately,
translational research can affect patients by changing the current standard
of care.
Regardless
of the geographic setting, the goals and challenges
of translational research are the same, says Liu: Getting funding and infrastructure support from the government, training young investigators, creating a multidisciplinary community
of researchers who can effectively communicate with each other, and finding ways to systematically implement
translational research results into
clinical practice.
The world
of clinical and
translational research requires the support
of individuals with varying expertise in diverse scientific and professional languages.
In the United States, most training opportunities are through the
Clinical and
Translational Science Awards (CTSAs), which were launched in 2006 based on the 2003 National Institutes
of Health (NIH) Roadmap for Medical
Research.
Translational — bench to bedside —
research remains a particular challenge in the
clinical neurosciences, in large part due to the inaccessibility
of the brain.
The pioneering
research led by academics from the Sheffield Institute
of Translational Neuroscience (SITraN), in collaboration with scientists from the University
of York, supports the fast - tracking
of the drug ursodeoxycholic acid (UDCA) for a
clinical trial in Parkinson's patients.
Translational Medicine: Bench
Research & Baby Brain Development to
Clinical Care Ruth Grunau, Ph.D., University
of British Columbia
The National Institutes
of Health's (NIH's) Roadmap for Medical
Research acknowledges the importance of behavioral and social science research, and the agency's Clinical and Translational Science Awards require a behavioral science component in the programs of awardee insti
Research acknowledges the importance
of behavioral and social science
research, and the agency's Clinical and Translational Science Awards require a behavioral science component in the programs of awardee insti
research, and the agency's
Clinical and
Translational Science Awards require a behavioral science component in the programs
of awardee institutions.
«Bioinformatics Instruction & Consultation, Collaboration, Evaluation» [PDF, 2.38 MB] Kristi L. Holmes, Ph.D., Becker Medical Library, Washington University in St. Louis «Community Engagement: Lost in Translation» [PDF, 2.1 MB] Layne Johnson, Ph.D.,
Clinical and
Translational Science Institute, University
of Minnesota «Supporting
Clinical Research» [PDF, 785 KB] Jennifer A. Lyon, M.S., MLIS, Biomedical and Health Information Services, University
of Florida «Library - based Support for
Translational Medicine» [PDF, 403 KB] Michele R. Tennant, Ph.D., MLIS, Biomedical and Health Information Services, University
of Florida
Together with the European Renal cDNA Bank and the Joint Institute for
Translational and
Clinical Research (a collaboration between Peking University Health Sciences Center and U-M), the U-M team found a simple, new test to identify one
of the nation's fastest growing chronic illnesses.
Other researchers include Randy Strong, Department
of Pharmacology and Barshop Institute for Longevity and Aging Studies, UTHSC, San Antonio, TX; Clifford Rosen, Center for
Clinical and
Translational Research, Maine Medical Center
Research Institute, Scarborough, ME; and Michael Nelson, Heart Institute, Cedars - Sinai Medical Center, Los Angeles, CA.
Back in the US, and further along the
translational pipeline is Doug Lowy,
of the NIH in Bethesda, Maryland, who has already experienced the potential
of harnessing basic
research for
clinical use.
Beyond the rigorous
research education essential for all scientists,
translational scientists who will work at the boundaries
of discovery and
clinical science must possess an assortment
of practical and logistical skills.
The study was supported by the Eunice Kennedy Shriver National Institute
of Child Health and Human Development (K23 HD054720), Flora Family Foundation, UCSF Catalyst Award, UCSF Resource Allocation Program, Brain & Behavior
Research Foundation Young Investigator Award, Stanford University Lucile Packard Foundation for Children's Health, Spectrum Child Health &
Clinical and
Translational Science Award and the Extraordinary Brain Series
of the Dyslexia Foundation.
For Fuster, «This is a clear example
of the type
of the collaborative and
translational research favored by the CNIC, in which
research groups with different interests and perspectives collaborate on
clinical problems that would not be easily resolved by teams working in isolation.»
This
research was also supported by the Clinical and Translational Research Institute of Southeast Wisconsin (NIH UL1RR
research was also supported by the
Clinical and
Translational Research Institute of Southeast Wisconsin (NIH UL1RR
Research Institute
of Southeast Wisconsin (NIH UL1RR031973.)
«
Clinical and
translational medicine represents an important arena
of investigation ripe for 21st - century science diplomacy, beginning with — although by no means limited to — infectious disease
research,» he and co-author Vaughan Turekian, chief international officer and director
of the AAAS Center for Science Diplomacy, write.
The SHOW project is supported by grants from the Wisconsin Partnership Program, the National Institutes
of Health (IRC2HL101468 - 01), and the UW Institute for
Clinical and
Translational Research (KL2 - RR025012).
The University
of Sheffield's Department
of Oncology and Metabolism conducts world - class
research from basic
clinical and
translational cancer
research to life course
research and basic level biology through to diseases such as diabetes and osteoporosis.
«Since several BACE1 inhibitors are currently being evaluated in
clinical phase 3 trials for the treatment
of Alzheimer's disease, the identification
of potential side effects will be
of great importance to ensure a positive
clinical outcome,» said Dr. Jochen Herms, a Professor
of translational brain
research at Ludwig - Maximilians - University Munich.
«Activation
of these cell receptors appear to prevent brain cells from cleaning out the trash — the toxic buildup
of proteins, such as alpha - synuclein, tau and amyloid, common in neurodegenerative diseases,» says the study's senior author, neurologist Charbel Moussa, MBBS, PhD, director
of Georgetown's Laboratory for Dementia and Parkinsonism, and scientific and
clinical research director
of the GUMC
Translational Neurotherapeutics Program.
«The exciting
research results being presented today underscore how transplants are becoming an increasingly successful treatment option for more patients with blood cancer than ever before,» said Jeffrey Miller, MD, moderator
of the press conference and Deputy Director
of the Masonic Cancer Center and the
Clinical and
Translational Sciences Institute at the University
of Minnesota in Minneapolis.
His primary
clinical and
research focus is dementia, with specific areas
of interest including biomarkers to assist in the diagnosis and understanding
of disease mechanisms for Alzheimer's and Parkinson's disease, and
translational research using novel therapeutic approaches.
Her
research is both
translational and
clinical in nature and centers on the human genetics
of healthy skin aging and diseases related to aging skin, including new treatments for advanced basal cell skin cancers.
«You shouldn't be testing everybody, but if there are reasons to believe that a test for H. pylori may come back positive, and it does come back positive, you should go on to treat,» says Dr. Traci Murakami, previous gastroenterology fellow at the UA and graduate
of the
clinical and
translational research graduate certificate at the Mel and Enid Zuckerman School
of Public Health, now an assistant
clinical professor
of medicine at the University
of Hawaii, Manoa, and lead author
of the study.
The life cycle
of a medical advance usually goes something like this: from discovery at the
research bench and replication
of findings, to
translational research and
clinical trials, to implementation.
Congress has questioned how NIH is managing its
Clinical and
Translational Science Awards, which support
research such as this aging study at the University
of Kansas.
BWF
Clinical Scientist Awards in
Translational Research provide $ 750,000 over 5 years to faculty members in the late - assistant - professor or early - associate - professor stages
of their careers.
The
research was supported by the Michigan Institute for Clinical and Health Research and Michigan Center for Diabetes Translational Research, both of which receive NIH
research was supported by the Michigan Institute for
Clinical and Health
Research and Michigan Center for Diabetes Translational Research, both of which receive NIH
Research and Michigan Center for Diabetes
Translational Research, both of which receive NIH
Research, both
of which receive NIH funding.
William Crowley, director
of clinical research for Massachusetts General Hospital in Boston, observes that, although NIH's many programs to support training in
clinical and
translational research have been «spectacular,» the academy is now filled with well - trained
translational researchers, all trying to land independent
research grants just as the NIH pay line is plummeting.
Now,
translational research has emerged as a field in its own right, aided in large part by the National Institutes of Health (NIH) Roadmap for Medical Research, a collection of initiatives that prioritize efforts to shepherd biomedical discoveries into clinical appl
research has emerged as a field in its own right, aided in large part by the National Institutes
of Health (NIH) Roadmap for Medical
Research, a collection of initiatives that prioritize efforts to shepherd biomedical discoveries into clinical appl
Research, a collection
of initiatives that prioritize efforts to shepherd biomedical discoveries into
clinical application.
Between those two extremes
of basic and applied knowledge lie two nascent, rapidly expanding subfields:
translational research informatics and
clinical research informatics.
«Beyond the rigorous
research education essential for all scientists, those
translational scientists who will work at the boundaries
of discovery and
clinical science must possess an assortment
of practical and logistical skills,» the editorialists write.
All
of the authors share a deep interest in
clinical and
translational research, and the editorial expresses a collective commitment to the development
of an effective
clinical and
translational research work force.
These ideas are summarized in a new paper, «Neuropsychiatric Signs and Symptoms
of Alzheimer's Disease: New Treatment Paradigms,» published in the journal Alzheimer's & Dementia:
Translational Research &
Clinical Interventions.
Bringing together bench and bedside is the purpose
of a new institute that aims to become a world - class «
translational» cancer
research centre, where the knowledge gained from basic
research is translated into
clinical applications.
«The unique aspect
of this approach is the ability to improve symptoms and decrease joint damage while potentially avoiding any negative effects on normal immune responses and susceptibility to infections,» adds co-author Gary S. Firestein, M.D., dean and associate vice chancellor
of Translational Medicine and director
of the
Clinical and
Translational Research Institute at UCSD.