Sentences with phrase «of coagulation factors»

Hemophilia results from a deficiency of the coagulation Factors VIII and IX.

February 01, 2008 Dr. Bin Zhang, PhD awarded prestigious Basil O'Connor Starter Scholar Research Award from March of Dimes The March of Dimes Foundation has awarded Bin Zhang, PhD, Assistant Staff, GMI, a Basil O'Connor Starter Scholar Award for his proposed work entitled,» Receptor - Mediated ER - to - Golgi Transport of Coagulation Factors V and VIII: Deficiencies in the Early Secretory Pathway as Pathogenic Mechanisms of Congenital Disorders.»

The strategy of giving a higher proportion of plasma is based on the belief that maintaining the balance of coagulation factors carried in plasma would reduce the overall amount of bleeding, requiring lower amounts of red blood cells and improving survival.

Some people, for example, undergo an intensive treatment called immune tolerance induction therapy, which involves regular intravenous administration of coagulation factors.

With the help of a coagulation factor called thrombin, fibronogen gets converted into fibrin during the blood clotting process.

Hemophilia A: a blood clotting disorder due to deficiency of coagulation factor VIII (this is the most common type of hemophilia in dogs).

Hemophilia A is a deficiency of coagulation factor VIII, and is the most common inherited clotting disorder in dogs.

Not exact matches

One such protein, tissue factor pathway inhibitor (TFPI), impedes the initiation of coagulation.

These cells, in turn, instruct factor - VIII — specific immune cells to become tolerant to the coagulation protein, resulting in suppression of misdirected antibody responses to the replacement therapy — all without affecting the rest of the immune system.

MetS factors include increased abdominal fat, high blood pressure, insulin resistance, abnormal blood coagulation and cholesterol levels as well as elevated C - reactive protein, an indicator of inflammation.

Only the three central coagulation factors, fibrinogen, thrombin and factor Xa, were increased during hibernation; together, these factors facilitate wound healing, only permitting local formation of blood clots when needed.

In a chromosomal inversion, the order of the base pairs on the chromosome are reversed so the gene doesn't express properly and the sufferer lacks the blood coagulation factor VIII (F8) gene, which causes blood to clot in healthy people.

«ECPR and a factor in the blood called protein C act as a «brake» on blood coagulation and endothelial cell inflammation and also enhance the viability and integrity of blood vessels, but when the malaria parasites use PfEMP1 to bind EPCR, they may interfere with the normal function of EPCR, and thus the binding can be the catalyst for the violent reaction,» he explains.

An international team of scientists have published a study in The Journal of Clinical Investigation, where they show that the disease is caused by a defective blood protein, the so - called coagulation factor XII.

The increased production of PAI - 1 and factor VII has been implicated in the development of coagulation and fibrinolytic abnormalities characteristic of obesity (28, 70).

Factor VIIIa is also inactivated by a protein in the coagulation cascade called activated protein C. Gale and his colleagues hope that activated protein C would still be able to degrade Factor VIIIa and that clotting would not get out of hand.

To read the article «An engineered interdomain disulfide bond stabilized human blood coagulation factor VIIIa» by A.J. Gale and J - L Pellequer, please see the Journal of Thrombosis and Haemostasis 1, 1966 - 71 (2003).

Inclusion Criteria: Subjects must have histologically or cytologically confirmed metastatic cutaneous or mucosal melanoma, Able to swallow and retain orally administered medication, Adequate hematological, renal, hepatic, and coagulation laboratory assessments Exclusion Criteria: Clinically significant bleeding within 4 weeks of screening, Current use of warfarin, factor Xa inhibitors, and direct thrombin inhibitors, Infection requiring anti-infective treatments within 1 week of study enrollment, Anti-tumor therapy, Major surgery within 28 days

The condition is a result of a deficiency or dysfunction in a coagulation factor known as Factor IX and it currently has nofactor known as Factor IX and it currently has noFactor IX and it currently has no cure.

Diabetes appears to diminish the in general more favorable cluster of risk factors of females compared with males, leading to greater differences in central adiposity and risk factors related to coagulation and inflammation between diabetes and nondiabetes in women rather than in men (33).

When injured, hemophiliacs tend to have a slow clotting (coagulation) process because of the lack of necessary blood factors (proteins).

Ellagica contains USP grade ellagic acid blended with herbs that support healthy coagulation parameters specifically chosen to counter the activation of Factor XII (the Hageman Blood Clotting Factor) that high doses of ellagic acid can trigger.

Dogs affected with VWDI have less than half of the normal level of von Willebrand coagulation factor (vWf), which is an essential protein needed for normal blood clotting.

Withnall E, Giger U. Effects of recombinant human activated factor VII and canine fresh frozen plasma in Beagles with hereditary coagulation factor VII deficiency.

Coagulation factor VII deficiency is inherited in an Autosomal Recessive manner in dogs meaning that they must receive two copies of the mutated gene (one from each parent) to develop the disease.

A plasma transfusion is sometimes given to dogs in moderate to severe cases in the hopes that it will inhibit active pancreatic enzymes and systemic inflammatory response; it also provides clotting factors that can help prevent and treat disseminated intravascular coagulation (DIC), an often lethal potential side effect of pancreatitis.

Due to the instability of the canine liver, blood may not coagulate or may end with a deficiency of vital factors needed for coagulation, thus leaving dog with either hypovolemia, anemia (low red blood cell count) or both.

Disseminated intravascular coagulation (DIC) is another syndrome which often accompanies SIRS and results in the in a bleeding tendency due to consumption of platelets and clotting factors.