Sentences with phrase «of codon substitution»

Mutation - selection models of codon substitution and their use to estimate selective strengths on codon usage.

Mutation - selection models of codon substitution and their use to estimate selective strengths on codon usage Yang, Z. and R. Nielsen.

Not exact matches

Scientists have noted previously that some people seem less susceptible to prion diseases if they have an amino - acid substitution in a particular region of the prion protein — codon 129.

Recently, we and others identified a recurrent somatic activating mutation in the JAK2 tyrosine kinase in polycythemia vera (PV), essential thrombocythemia (ET), and myeloid metaplasia with myelofibrosis (MMM).9 - 13 This mutation results in a valine to phenylalanine substitution at codon 617 within the Jak homology domain 2 (JH2) pseudokinase domain of Janus kinase 2 (JAK2).

The mutation is a G → A substitution at c. 1473 + 1, which destroys a splice donor recognition site in intron 10 and causes exon skipping that results in a frameshift and the introduction of a premature termination codon [129].

This led to the eventual identification of a single nucleotide substitution in the second codon of a previously unknown gene that is now known to be the cause of PRCD in at least 18 different breeds [23].