Recent studies have revealed the existence of a long asymptomatic phase, where the pathological changes leading to AD begin — at least - decades before the first symptoms
of cognitive decline appear [2 — 4].
Not exact matches
Fernando Pagan, a GUMC associate professor
of neurology who directs the Movement Disorders Program at MedStar Georgetown University Hospital, said that to his knowledge, the study «represents the first time a therapy
appears to reverse — to a greater or lesser degree depending on stage
of disease —
cognitive and motor
decline in patients with these neurodegenerative disorders.»
Instead
of impairing learning and memory, as it does in young people, the drug
appears to reverse age - related
declines in the
cognitive performance
of elderly mice.
«Now that we have more evidence that serotonin is a chemical that
appears affected early in
cognitive decline, we suspect that increasing serotonin function in the brain could prevent memory loss from getting worse and slow disease progression,» says Gwenn Smith, Ph.D., professor
of psychiatry and behavioral sciences at the Johns Hopkins University School
of Medicine and director
of geriatric psychiatry and neuropsychiatry at Johns Hopkins University School
of Medicine.
«They have isolated one druggable target that
appears to rejuvenate age - related
cognitive decline in the hippocampus,» says biologist Eric Blalock
of the University
of Kentucky who was not involved in the study.
Thus, brain atrophy rate
appears to be a major determinant
of cognitive decline in this population.
Activities that stimulate the brain — such as learning a new language, playing brain - teasing games, or doing crossword puzzles —
appear to delay the onset
of dementia, says Dr. Steinerman, although its still unclear if they can actually prevent or slow down
cognitive decline.
Researchers from the Wake Forest School
of Medicine found that aerobic exercise
appears to boost thinking skills and brain volume in adults diagnosed with mild
cognitive impairment, a condition that sits in between normal age - related memory
decline and more serious dementia.
The fact that men
appear to have higher rates
of MCI but lower rates
of dementia may hold important clues for preventing or delaying
cognitive decline, the researchers suggest.
Certain types
of mental
decline result from exposure to toxins and to both endogenous and exogenous oxidizing agents — all
of which
appear to contribute to brain inflammation, scarring and
cognitive impairment.