Sentences with phrase «of complex diseases»

We deliver progress, specifically contributing to the body of medical knowledge on quality of life and the treatment of complex disease.

The influence of genetic background on spontaneous and genetically engineered mouse models of complex diseases.

It sets the stage for large - scale sequencing of complex disease.

It is thought that the incidence of any complex disease is dependent on a balance of risks, too many negative genetic and environmental factors and the balance can be tipped towards disease.

This essentially gives us «barcodes» of specific gene loci, which we can use to help untangle the complex genetics of complex diseases,» said Andrey Rzhetsky, PhD, professor of genetic medicine and human genetics at the University of Chicago, who led the study.

In fact, Ostrander, who works at the NHGRI's Cancer Genetics and Comparative Genomics Branch, was one of the lead authors of a white paper arguing for support to sequence the dog genome at a level of quality already available at the time for the mouse, «to better understand the genetic basis of complex diseases affecting both human and dog.»

As you might expect for a major genome center, there are many projects from small family - based studies to large trio studies to massive studies of complex disease involving thousands of unrelated samples.

As efforts continue to characterise the genetic underpinnings of complex diseases, the data and results of this study are expected to enable the next wave of discoveries.

UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age.

«Rather than focusing on readmissions, preventable or otherwise, time may be better spent in developing quality measures of complex disease management across a patient's continuum of care,» they write.

Research focus My research is focused on understanding detailed mechanisms of complex diseases, including Inflammatory Bowel Disease, with the ultimate goal of finding an appropriate treatment for patients.

The four grantees of the CCDG program had proposed a diversity of projects across a rather wide spectrum of complex diseases.

Unlike monogenic diseases, which are caused by a single mutation in the genome, cardiovascular diseases belong to the group of complex diseases.

Highlighting the collaboration, Hughes said, «This study demonstrates how the synergy between experimental and computational approaches can help unravel the nature of a complex disease such as HD.»

«Ten years ago, geneticists worked in isolation, but now there is a premium on leadership — individuals able to pull together consortiums of geneticists to amass the cohorts of thousands of subjects required to address problems of complex disease genetics,» he says.

Even so, scientists have been able to link CNVs to a handful of complex diseases.

«Validation of a complex disease is very exciting.»

dSysMap (which stands for «Disease - mutations Systemic Mapping») is a computational tool to interpret the effect of genetic mutations on the development of complex diseases.

«The genome gives finite boundaries to what we have to learn [in terms of complex diseases] and the comparison between two genomes makes the search more refined,» says Robert H. Waterston of the Washington University Genome Sequencing Center in St. Louis and a leader of the consortium.

Many numbers have been tossed around as the minimum requirement to comprehensively study the genetic architecture of complex disease.

MAP technology also supports RBM's drive to develop diagnostics that aid in the detection of complex diseases and conditions in areas of unmet medical need such as neuropsychiatry, nephrology, immunology and cardiology.

Rubin and Kohane believe that using models derived from human stem cells in conjunction with electronic medical records could provide a wealth of information about the subtypes of complex diseases, perhaps leading to individualized treatments.

24/3: 45 The X-factor of complex disease: Methods, software, and extensive application for studying the X chromosome in association studies.

Since 2004, the National Eczema Association has funded research to help better understand why eczema develops and evolves, its impact on those who have it, and how to best manage the symptoms of this complex disease.

She has taken a truly personal experience within her family and has transformed her life and her practice of medicine into a deep understanding of complex disease, the discovery and detective process as to why disease happens, how to address the root cause, and ultimately promote health and wellness.

Our pediatric nephrologists specialize in the treatment of this complex disease and do our best to provide care for children with nephrotic syndrome in the outpatient clinic.

The research will lead to uncovering a sizable portion of the heritable basis of complex disease that has not been explained by GWAS loci, to revealing the role of ChrX in age - related diseases, and to advancing the exploration of the sex - linked genetic basis of sex - specific aging patterns.

«Statistical test increases power of genetic studies of complex disease.»

His research interests include the molecular underpinnings of cervical cancer (including developing genetic screens), the identification of the genetic determinants of quantitative traits in humans, and the application of massively parallel sequencing technology for understanding the genetics of complex disease.

This work illustrates how the study of inbred canine populations can provide new insights into the genetic underpinnings of complex disease, bridging the gap between small rodent models and humans.

«We think that by restoring the natural «microbial identity» of laboratory mice, we will improve the modeling of complex diseases of free - living mammals, which includes humans and their diseases,» said Barbara Rehermann, M.D., senior author of the paper.

Stem cells offer an unusually powerful new therapeutic platform to treat some of the largest and fastest growing unsolved problems in medicine through the use of healthy and functional human cells to address the underlying mechanisms of complex disease.

Molecular genetic findings support the thesis that dopaminergic, serotonergic, and noradrenergic neurotransmission pathways account for the etiology of this complex disease.

AAH has three full - time internal medicine specialists on staff, who are experts in the management of a wide spectrum of complex diseases.

These conditions, as well as the ubiquitous impact of menarchal and menopausal timing on women's health, demand the focus of complex disease and evolutionary geneticists.

They are of high interest for the study of complex diseases that have no clear mutational cause,» said Yamashita, who added the alanine threonine substitution was a rare variant.

In 2007, researchers came to appreciate the extent to which our genomes differ from person to person and the implications of this variation for deciphering the genetics of complex diseases and personal traits.

The researchers said the work demonstrates that, in fact, multi-tissue, multi-individual data can be used to identify the mechanisms of gene regulation and help to study the genetic basis of complex diseases.

These results further establish our leadership role in deciphering the genetics of complex diseases.

Be it the management of complex diseases, metabolic and weight - loss support, anti-aging strategies, or general health optimization and prevention; the COE, a recognized world - leader in naturopathic medicine is here to help.

VCA Sacramento Veterinary Referral Center works closely with local referring veterinarians, sharing information on diagnostics, sophisticated medical techniques and treatments of complex diseases and injuries, all with the singular goal of improving the quality of life for our patients.

Diabetes is one of the most common feline endocrine diseases and, while we do not know all of the causes of this complex disease, we do know that many diabetic cats cease needing insulin or have their insulin needs significantly decrease once their dietary carbohydrate level is lowered to a more species - appropriate level than that found in many commercial foods — especially dry kibble.