Sentences with phrase «of condensin»

More specifically, we have been studying the roles of the condensin and cohesin complexes in 3D genome organization in the fission yeast, mouse and human systems.

Scientists from the Cees Dekker group at the Kavli Institute of Nanoscience at Delft University, together with the Christian Haering group from EMBL Heidelberg who established the purification and fluorescence labeling of the protein, managed to make actual movies that caught the action of the condensin complex in the act — that is, while it was extruding a loop of DNA.

Where the second type of condensin, which is present in humans and other multicellular organisms, binds during cell division is another future line of inquiry.

Large amounts of condensin also accumulate at areas where RNA is created.

Not exact matches

The protein complex, called condensin, is one of many that become active when cells replicate.

This type of yeast shares many important genes with us and also has one of the two known condensin complexes in humans.

Condensin is also crucial in the organisation of the chromosomes during cell division, and errors in the process can result in cancer.

Researchers from the Kavli Institute of Nanoscience at Delft University and EMBL Heidelberg now managed for the first time to isolate and film the process, and witnessed — in real time — how a single protein complex called condensin reels in DNA to extrude a loop.

Artist's impression of how a condensin protein complex extrudes a loop of DNA for the spatial organization of chromosomes.

The looping speed was found to be remarkably high: up to 1500 base pairs of DNA can be reeled in by condensin per second.

One theory stated that condensin works like a hook that can grasp and connect DNA within the jumble of DNA, thus tying it together.

Condensin II is one such complex that promotes condensation of DNA in prophase of mitosis and organizes DNA loops and formation of chromosome territories during interphase.

Exploring a potential role for CAP - D3 / Condensin II in the pathogenesis of Inflammatory Bowel Disease

Importantly, these studies to elucidate gene contacts in the 3D nuclei of live cells have demonstrated that condensin - mediated contacts between centromeres and the genomic loci carrying Pol III - transcribed genes or retrotransposons are highly dynamic.

We have shown that the human condensin complex functions in global 3D genome reorganization during the important process of cellular senescence (Yokoyama et al..

We found that the interaction between two classic factors, condensin and TBP, plays a pivotal role in 3D chromosome organization, and ensures that a critical set of genes, the actively transcribed housekeeping genes, are accurately segregated during mitosis (Figure B and C).

Cohesin forms small topological chromatin domains of approximately 100 kb, while condensin organizes 300 kb — 1 Mb domains.

These studies demonstrate that the two important protein complexes, condensin and cohesin, are both essential for the assembly of the functional genome architecture, but their roles in the 3D genome organization (gene contacts and topological domain organization) are significantly different.