Recognized causes
of congenital hypothyroidism in cats include intrathyroidal defects in thyroid hormone biosynthesis (dyshormonogenesis), an inability of the thyroid gland to respond to TSH, and thyroid dysgenesis.
Dr. John C. Fyfe - In a cooperative effort of TFT breeders, veterinarians, and a canine genetics researcher at the Michigan State University College of Veterinary Medicine, the genetic basis
of congenital hypothyroidism with goiter (CHG) in Toy Fox Terriers (TFT) has been discovered, and a DNA - based carrier test is now available.
Breeders rushed to get their dogs certified clear
of Congenital Hypothyroidism With Goiter (CHG) a gene which, if present, kills the dog within 2 weeks of birth.
Not exact matches
Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient
Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability
Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because
of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women
(borrowed from Dr Kitty) Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient
Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability
Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because
of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women
In a retrospective study, we further illustrate the application
of PVP for the interpretation
of whole exome sequencing data in patients suffering from
congenital hypothyroidism.
As a result, majority
of patients with
congenital hypothyroidism who, despite being «overtreated» with Levothyroxine, did not manifest signs
of hyperthyroidism.
Congenital hypothyroidism results from either an improperly formed gland, or as a result
of antithyroid medications ingested by the mother during pregnancy.
Congenital hypothyroidism due to iodine deficiency is the most common preventable cause
of mental retardation in the world.
Other sources
of dry eye include drug toxicity (antibiotics such as sulphadiazine and sulphasalazine can cause temporary or permanent dry eye in some animals), drug - induced reaction (atropine and topical anesthetics temporarily reduce tear production), neurological impairment (damage to the nerves leading to the lacrimal glands), removal
of the third eyelid (see Cherry Eye), systemic disease (e.g. distemper), chronic conjunctivitis, trauma to the tear glands,
hypothyroidism,
congenital disease (some dogs are born without lacrimal glands), breed predisposition.
His reply raised more questions than it answered so I forwarded it to a group
of long time breeders and asked if they, or anyone they knew, had produced a litter containing
congenital hypothyroidism with goiter (CHG).
«The research in my laboratory on canine
congenital hypothyroidism has been funded by the National Institute
of Child Health and Development in recognition that discoveries in dog disease are often relevant to human disease.
I say «almost entirely» because we have observed
congenital hypothyroidism with goiter in a litter
of golden retriever pups in which the bitch was ill advisedly supplemented with kelp powder during late gestation and lactation.
Congenital hypothyroidism occurs in different forms in different breeds caused by various abnormalities
of the hypothalmus, the pituitary gland, or the thyroid glans itself.
Previously, we have worked primarily on the
congenital hypothyroidism of giant schnauzers originally reported by Greco DS, et al (JVIM 1991; 5:57 - 65), but when approached last year by TFT breeders and their veterinarians, we initiated study
of the TFT disorder.
Clinical signs usually appear between 2 and 6 years
of age, but may occur very young (
congenital hypothyroidism).
Some
of the health conditions known to affect the Alaskan Husky breed include
hypothyroidism, progressive retinal atrophy,
congenital deformation
of the larynx, and various stomach and bowel issues.
Editors Note: Only one report
of suspected
Congenital Hypothyroidism With Goiter has been received.
If you KNOW
of a Toy Fox Terrier litter that contained
congenital hypothyroidism with goiter (CHG) we ask you to email the editor.
The result
of two negative recessive genes combining is a real health problem — the kind
of problems we are increasingly seeing in Kennel Club dogs: epilepsy, dysplasia, deafness,
congenital skin conditions, heart murmurs, cataracts, polyarthritis, progressive renal atrophy, allergies,
hypothyroidism, and Cushing's Syndrome, to name a few.
Congenital secondary
hypothyroidism (associated with clinical signs
of disproportionate dwarfism, lethargy, gait abnormalities, and constipation) has been reported in Giant Schnauzers, Toy Fox Terriers, and Scottish Deerhounds.
In primary
congenital hypothyroidism, enlargement
of the thyroid gland (goiter) also may be detected, depending on the cause
of the
hypothyroidism.
Other rare forms
of hypothyroidism in dogs include neoplastic destruction
of thyroid tissue and
congenital (or juvenile - onset)
hypothyroidism.
In foals,
congenital hypothyroidism may develop when pregnant mares graze plants that contain goitrogens, or are fed diets either deficient in or containing excessive amounts
of iodine.
Congenital primary
hypothyroidism may result from one
of various forms
of thyroid dysgenesis (eg, athyreosis, thyroid hypoplasia) or from dyshormonogenesis (usually an inherited inability to organify iodide).
The main purpose
of treating
congenital hypothyroidism is to keep the patient in an euthyroid clinical condition, providing thus normal growth, adequate psychomotor and pubertal development.