Sentences with phrase «of contractile»

This type of exercise forces your muscles to contract as hard as they can, which leads to an increase in the number of contractile filaments within your muscle cells.

The heavy loads allow for myofibrillar protein synthesis to take place which, as discussed, will increase the size of the contractile proteins.

From a neuromuscular standpoint, functional programs increase the neural drive to the muscles, improve the synchronization of motor units, increase the activation of contractile apparatus, and decrease inhibition of protective mechanisms of muscle.

so, at the right doses we will have calcium release from the endoplasmatic reticulum through amentoflavone equalling that of 4000 mg caffeine (thats a lot of contractile strength), there will be 3g of calcium orotate, prviding the best absorbed calcium source and orotic acid, which works together with creatine, pyruvic acid, fumaric acid, ubiquinol and shilajit to

The foundation behind PAP, on a cellular level, is that this style of training enhances the binding rates of contractile proteins which causes faster muscle contractions.

The above description of the contractile properties of each muscle fiber type might lead you to believe that each type of fiber has distinct contractile properties.

But the broad range of contractile properties across all muscle fibers means that fibers of the same type do not all have the same level of strength, endurance, or speed.

Sarcomeres perform the muscle's contraction with the help of the contractile proteins myosin and actin, which cause the sarcomere to shorten.

When you are able to increase the number of contractile proteins called actin and myosin, it increases the ability of muscles to contract and perform physical work.

Most clients, and fitness professionals alike, use the term «tight» to indicate that a muscle or other form of contractile tissue is shorter than it should be.

This leaking process increases the levels of calcium and activates specific enzymes called «calpains», whose role is to remove the damaged parts of the contractile filaments.

Almost 80 % of the muscle fiber's density is comprised of these contractile parts, which leaves a great potential for muscle size growth.

The loss of contractile cells and the inability of the adult mammalian heart to regenerate is a major cause of cardiac dysfunction and heart failure.

Regardless of its nature, dorsoventral axis inversion (35) would have brought the ventral midline tissue into a dorsal position in the chordate lineage, and the appearance of incompressible vacuoles (14) would have gradually transformed it into a stiff rod of constant length; the amphioxus notochord could then be regarded a vestige of a contractile - cartilaginous transition.

Here we study the effect of contractile forces originated from model tumor spheroids embedded in a biomimetic collagen I matrix.

MYH6 encodes one form of myosin, a major component of the contractile system of the heart, and was recently associated with the function of the conduction system of the heart by studies from deCODE and others.

Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly.

Their contribution to the formation and maintenance of the contractile apparatus highlight an unconventional role for clathrin flat lattices in skeletal muscle which may be relevant to pathophysiology of several neuromuscular disorders.

For example, he explains, smooth muscle cells grow thicker in large blood vessels like arteries, but similar type of contractile cells begin to die off in tiny blood vessels in the eye.

Clara Franzini — Armstrong writes about Annemarie Weber, «a major contributor to the renaissance of muscle biology research in the 1950s to 1970s, when the components of the contractile machinery were identified; novel views of muscle contraction and regulation were elucidated; and principles of energy transduction, motility and intracellular signaling common to all cells were revealed.»

In vitro experiments in myogenic cells initially suggested that IL - 15 was an anabolic factor for skeletal muscle, able to stimulate the accumulation of contractile protein in differentiated myotubes (8 — 10).

Not exact matches

These tests indicate that myomerger - deficient muscle cells called myocytes differentiate and form the contractile unit of muscle (sarcomeres), but they do not join together to form fully functioning muscle tissue.

In this research, Yousaf and his team made a scaffold free beating tissue out of three cell types found in the heart — contractile cardiac muscle cells, connective tissue cells and vascular cells.

Myofibroblasts produce large amounts of extracellular matrix material such as collagen, are contractile, and secrete a variety of cytokines and chemokines, all of which enhance scar formation.

The tissue, called the stroma, includes fat cells, or adipocytes, that provide padding; fibroblasts, which make the framework for tissue; pericytes in blood vessels, which are contractile cells that help regulate blood pressure; as well as myoepithelial cells comprising the outer layer of the ductal system through which milk flows.

The new study shows that the proportion of patients with a severely deteriorated heart contractile function is much less (60 %) in the group that received metoprolol.

Case Western Reserve researchers already demonstrated that a single protein plays a pivotal role in the use of nutrients by major organs that allow for the burning of fat during exercise or regulating the heart's contractile and electrical activity.

But when physiologist H. Lee Sweeney of the University of Pennsylvania School of Medicine in Philadelphia and his colleagues put this faulty gene into embryonic quail muscle cells growing in lab dishes, the cells made a shortened version of the protein and incorporated it into their contractile machinery.

The contractile activity of smooth muscle cells in the walls of cerebral arteries determines the degree of constriction they experience (known as arterial tone) and thereby controls blood flow.

«In this study, we developed a novel method for controlled crumpling of graphene and graphite via heat - induced contractile deformation of the underlying substrate,» explained Michael Cai Wang, a graduate student and first author of the paper, «Heterogeneous, Three - Dimensional Texturing of Graphene,» which appeared in the journal Nano Letters.

Specifically, lower isometric forces coupled with a lower twitch / tetanus ratio and lower rates of force development and relaxation indicate that EDL muscles from IL - 15Rα — KO mice have adopted a slower contractile phenotype.

These morphological data highlight a unique feature of fast muscles that are IL - 15Rα deficient, which likely contributes to the slower contractile characteristics we observed in these normally fast muscles.

The observation of reduced calsequestrin in the muscles of IL - 15Rα — KO mice is interesting inasmuch as calsequestrin concentrations are reported to be higher in fast muscles (52) and fast muscles from calsequestrin - 1 — null mice display contractile characteristics similar to those of slow muscles, including longer contraction times and half - relaxation times (ν RTs)(53).

Because the phenotypes were distinct in these knockout mouse models with respect to spontaneous cage activity and fast muscle isometric contractile characteristics, we can conclude that the roles of IL - 15Rα and IL - 15 in vivo are distinct with regard to muscle function.

Isometric twitch and tetanic contractions were performed using a stimulator and a force transducer to quantify the maximum contractile forces, as well as parameters related to the speed of contraction and speed of relaxation of dissected muscles.

Isometric contractile properties of fast muscles from IL - 15Rα — KO mice display a slower contractile phenotype.

On this basis, we propose that IL - 15Rα has a role in determining the contractile and morphological phenotypes of fast skeletal muscles in vivo.

The isometric contractile properties of EDL muscles from IL - 15Rα — KO mice were also consistent with the adoption of a slower contractile phenotype.

The understanding of this group of disorders has advanced in recent years through the identification of the causative mutations in the gene encoding one of the major proteins of the basic contractile unit of skeletal muscle, i.e., actin.

Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin - induced diabetic atrophy.

Rab8a regulates the exocyst - mediated kiss - and - run discharge of the Dictyostelium contractile vacuole.

An anthelmintic drug, pyrvinium pamoate, thwarts fibrosis and ameliorates myocardial contractile dysfunction in a mouse model of myocardial infarction.

It is thought that using HRT, at least in part, reduces modifications of muscle contractile proteins that are linked to ageing.»

Abstract Costameres represent specialized focal adhesion sites of muscle fibres, located between the plasma membrane and sarcomeres, the contractile units of muscle.

Abstract The amount of force skeletal muscles can produce depends on their contractile history.

Oxytocin - and NAADP - mediated effects were investigated by using contractile measurements of whole uterine strips from rat in organ baths.

Health and Medicine Reporter Research Aliquots American Heart Association cell and developmental biology cell division contractile ring Human Frontier Science Program Journal of Cell Biology kathleen gould lipid NIGMS NIH Reporter Nov 10 2017

Finally, in a collaboration with Frank Jülicher's group at the Max Planck Institute for the Physics of Complex Systems, we are using these data to develop physical models that will help us understand how local cellular adhesive, elastic and contractile properties are influenced by PCP proteins and other molecules, and how they combine to produce specific packing geometries at a global level.

«We don't know why conversion of fibroblasts to the contractile phenotype is sometimes helpful and sometimes harmful.

Some of the recognized challenges are poor engraftment of implanted cells and, in the case of human cardiomyocytes, functional immaturity and lack of electrical integration, leading to limited contribution to the heart's contractile activity and increased arrhythmogenic risks.