Armed with knowledge of which mistakes in genes are driving which cancers, doctors and scientists will be able to maximise the chances
of cure for each patient by picking the best treatments and by developing new and more targeted treatments for people with oesophageal and prostate cancers in the future.
Not exact matches
While the new mid-stage study results from DNDi were impressive (they showed
cure rates
of 96 % to 97 % even
for the sickest
patients and those with liver scarring), more late - stage trials will be necessary before the drug is available on a large scale in the developing world.
This week,
for the first time, a hospital edited the genes
of a
patient, to
cure him, one hopes.
When faced,
for example, with the decision
of whether or not to let a seriously ill or irreversible
patient succumb voluntarily in terminal situations, we might avoid making the decision now, arguing
for the possibility — maybe next week — that a new
cure for the
patient's condition will be discovered.
As we read this history, the furor over stem cells was fueled by numerous factors: the near - universal human desire
for magic;
patients» desperation in the face
of illness and their hope
for cures; the belief that biology can now do anything; the reluctance
of scientists to accept any limits (particularly moral limits) on their research; the impact
of big money from biotech stocks, patents, and federal funding; the willingness
of America's elite class to use every means possible to discredit religion in general; and the need to protect the unlimited abortion license by accepting no protections
of unborn human life.
In listening to our terminally ill
patients, we were always impressed that even the most accepting, the most realistic
patients left the possibility open
for some
cure,
for the discovery
of a new drug or the «last minute success in a research project.»
Either a woman is actually raped (South Africa has the highest rate
of rape in the world; the rumor
of the «virgin
cure» has sent male AIDS
patients on the hunt
for younger and younger girls to rape), or she is pressured socially and economically.
For every 11
patients with H. pylori who are treated with antibiotics, 10 are
cured of their peptic ulcer.
The Bill - which was passed by the House
of Lords - would have allowed doctors to test cutting edge new treatments on
patients to help find
cures for cancer and other serious illnesses.
The hospital opened in 1913 to treat tuberculosis
patients and was the site
of the first clinical trials
for the hydrazides treatment that eventually led to the
cure of the disease, according to the EDC.
Patients First and
Cure the NHS will accuse the Prime Minister
of double standards
for vowing to prosecute incompetent hospital staff but not the bureaucrats behind the system.»
For example, a consortium
of research groups called the London Project to
Cure Blindness aims to test RPE transplants from embryonic stem cells in
patients with macular degeneration this year.
«It's not going to
cure arthritis, but it will delay the progression
of arthritis to the damaging stages when
patients need joint replacements, which account
for a million surgeries a year in the U.S.»
As treatments
for HCV have evolved, genotype 3
patients have become the most difficult subgroup
of patients to
cure.1 Although there have been recent advances in direct - acting antiviral therapies
for HCV genotype 1, genotype 3 remains a challenge and is a highly prevalent strain
of the infection globally, with a particularly high concentration
of cases in Asia.1
For young AML
patients with suitable bone marrow donors, transplantation offers the best chance
of a
cure.
Patients and doctors know all too well that cancer is not one disease and there is no singular
cure for the complex group
of disorders.
And although they may represent only another small step toward a «
cure»
for diabetes, they are beginning to provide
patients with levels
of control never before seen over their own hormones.
And, longer - term, misdiagnosing Zika as dengue has another complication:
Patients may not be on the lookout
for the weakness that could signal the early onset
of the associated autoimmune disorder; Guillain — Barré has no
cure but there are several therapies they could tap that are known to help speed recovery — involving blood removal or injections
of donor proteins.
The drug offered a first sliver
of hope
for patients waiting
for a
cure, or at least something to slow down the disease's staggering march.
Ocrevus isn't a
cure, and it offers no relief
for 30 to 40 percent
of patients with primary progressive MS. Davis was in that disappointed group.
However, many industry insiders say these changes are opening up unique opportunities
for researchers who focus on translating basic science into real - world
cures and are eager to explore the molecular mechanisms
of disease, test hypotheses, and do work that benefits
patients.
A new drug is offering dramatic
cure rates
for hepatitis C
patients with two subtypes
of the infection — genotype 2 and 3, say a team
of scientists led by Weill Cornell Medical College researchers.
«But the optimal duration
of treatment
for genotype 3
patients, in order to maximize their chance
of cure, remains undefined.
Current chemotherapy treatments
cure the disease in fewer than 10 %
of patients who have a FLT3 mutation — partly because toxic chemotherapy drugs can be used
for only a few days at a time, not killing as many cancer cells as they might.
«Funding research focused on helping
patients survive longer is critical, and studies such as this advance our goal
of not only improving treatments
for brain cancer, but eventually finding a
cure.»
Reports
of laboratory advances have to be hedged in cautious language
for the sake
of patients and their families, talking in terms
of «treatment» and «survival» rather than «
cures».
Researchers have used radioimmunotherapy (RIT) to destroy remaining human immunodeficiency virus (HIV)- infected cells in the blood samples
of patients treated with antiretroviral therapy, offering the promise
of a strategy
for curing HIV infection.
«We're at a pivotal point where we're building upon what we've learned in the PLAT - 02 trial and opening new trials, like PLAT - 04, with the goal
of improving this therapy to the point that it becomes a long - term
cure for all
of our leukemia
patients,» said Dr. Corinne Summers, an oncologist at Seattle Children's and the lead investigator
of the PLAT - 04 trial.
A 2013 paper in the same journal reported excellent vocal outcomes
for the first 92 treated
patients, but neither paper included the kind
of follow - up data required to confirm the treatment's long - term effectiveness in
curing the tumors.
For most
of the solid tumors that we work with, unfortunately, once the cancer has spread to a distant place, we're at this point unable to
cure those
patients, although we can oftentimes improve their quality
of life or make them live longer.
The first long - term study
of a pioneering endoscopic laser treatment
for early vocal - cord cancer, developed at Massachusetts General Hospital (MGH) and previously shown to provide optimal voice outcomes, finds that it is as successful as traditional approaches in
curing patients» tumors while avoiding the damage to vocal quality caused by radiotherapy or by conventional laser or cold - instrument surgery.
«It is through studies like these that we continue to move closer to better treatments, and eventually finding a
cure,
for these
patients who so desperately need our help,» said Catherine (Bracken) Ivy, founder and President
of The Ben & Catherine Ivy Foundation.
For his part, Edgerton is cautious about saying that he's found a
cure or that this treatment will get spinal injury
patients out
of their chairs and strolling down the street.
«AML is a disease in which fewer than 30 percent
of patients are
cured,» said co-senior author Ulrich Steidl, M.D., Ph.D., associate professor
of cell biology and
of medicine and the Diane and Arthur B. Belfer Faculty Scholar in Cancer Research at Einstein and associate chair
for translational research in oncology at Montefiore.
Although the
cure rate
for breast cancer is high — it has an 89 percent 5 - year survival rate — a large number
of patients have a recurrence
of their cancer.
Current treatments include transplanting
patients with donor HSC, which is a potential
cure for SCD, but due to the serious risks
of rejection, only a small number
of patients have undergone this procedure and it is usually restricted to children with severe symptoms.
No
cure or vaccine is available
for Lassa fever, but the antiviral drug ribavirin may help
patients if taken early in the course
of the disease.
Establishing a link between allergens and atopic dermatitis remains challenging
Patients and parents
of young atopic dermatitis
patient's often request allergy testing to find triggers that they hope will offer a «
cure» or reduce the need
for atopic dermatitis treatment.
In the past, ulcer
patients underwent stomach operations or took medicines
for life, he says; thanks to Warren and Marshall, a simple course
of antibiotics is often enough to
cure them completely.
But as recently as the early 20th century, intentional infection was seen as cutting - edge: Austrian psychiatrist Julius Wagner - Jauregg won the 1927 Nobel Prize in Physiology or Medicine
for injecting blood from people with malaria into
patients with neurosyphilis, which putatively
cured them
of insanity and paralysis.
Other researchers say the degree
of recovery is remarkable, perhaps even unprecedented, but they caution that the procedure didn't produce a complete
cure and may not work as well
for patients who are older or have more severe injuries.
One is the lack
of detectable virus in the blood plasma
of patients on effective ARV therapy, which makes it difficult
for researchers to assess whether an intervention aimed at
curing the infection is working.
The researchers found that the WHO criterion
for «
cure» could not be applied in the majority
of patients.
It is worthwhile to give
patients expensive new drugs that can
cure their hepatitis C much earlier than some insurers are now willing to pay
for them, according to a UC San Francisco study that models the effects
of treating the disease early versus late in its development.
While certain
patients, particularly infants, enjoy
cure rates
of 90 percent or better, the outlook is worse
for high - risk
patients, including those whose disease has spread widely.
We only have two years
of data on how
patients are doing on the drug, and it's premature to say whether it will be a
cure for them.»
Given such debilitating effects, an aggressive search is on among scientists to find a
cure for MS. Currently available therapies are only partially effective, however, in preventing the onset
of permanent disability in MS
patients.
More than 30
patients have been treated
for SCID, and more than 90 percent
of those children have been
cured of their disorder — an improvement over the 50 percent chance
of recovery offered by bone marrow transplants.
The study reports that 13
of 34 (38 %)
patients who achieved complete remission have remained disease - free
for over five years and may be
cured.
Although the treatment worked in only two
of 17
patients, the researchers say this proof
of concept, reported online today in Science, should pave the way
for more gene - therapy cancer
cures.