CPX - 351 is a liposomal formulation
of cytarabine and daunorubicin.
«Overall there appears to be a benefit of a fifth course
of cytarabine in low - risk patients with AML,» said Kelly D. Getz, PhD, of the Children's Hospital of Philadelphia, who presented the results.
They noted that the addition
of cytarabine to the initial regimen may have contributed to the persistence of response after therapy discontinuation, but that remains unclear.
Not exact matches
Seventeen patients received GO alone when MRD was detected after two rounds
of chemotherapy with the drugs
cytarabine, daunorubicin and etoposide.
When used alongside standard chemotherapy agents daunorubicin and
cytarabine in a treatment - resistant AML model, 99.7 percent
of cancer cells were killed.
1) Rituximab was added to the induction as the majority
of PCNSL are CD20 + diffuse large B - cell lymphomas (DLBCL) and it was previously shown that the addition
of rituximab to CHOP chemotherapy has improved the prognosis in DLBCL outside the brain.8 2) The intraventricular MTX /
cytarabine treatment
of the Bonn protocol requiring an Ommaya reservoir was replaced by intraspinal administration
of liposomal
cytarabine in view
of the expected lower risk
of procedure - related infections.
A Phase 1/2, Multicenter, Open - label Study
of FT - 2102 as a Single Agent and in Combination with Azacitidine or
Cytarabine in Patients with Acute Myeloid Leukemia or Myelodysplastic Syndrome with an IDH1 Mutation
The patient was treated on an acute lymphoblastic leukemia (ALL) protocol for eight cycles
of hyperCVAD (cyclophosphamide, vincristine, adriamycin and decadron) alternating with MTX / Ara - C (methotrexate and
cytarabine) and achieved complete remission (CR) confirmed by a bone marrow biopsy and by the resolution
of most
of her skin lesions.
Removal
of a fifth course
of chemotherapy containing
cytarabine resulted in worse overall survival and disease - free survival in pediatric patients with low - risk acute myeloid leukemia (AML), according to the results (abstract 10515)
of a pooled analysis
of two Children's Oncology Group (COG) trials presented at the 2017 American Society
of Clinical Oncology (ASCO) Annual Meeting, held June 2 — 6 in Chicago.
A total
of 200 liposomal
cytarabine treatments, (median 4, range 1 — 4) were delivered to 66 patients.
A combination
of the FLT3 kinase inhibitor quizartinib with 5 - azacitidine or low - dose
cytarabine is active in patients with FLT3 - ITD mutated myeloid leukemias, according to a new study.
A combination
of the FLT3 kinase inhibitor quizartinib with 5 - azacitidine (AZA) or low - dose
cytarabine (LDAC) is active in patients with FLT3 - ITD mutated myeloid leukemias, according to a new study.
The study had begun as a comparative study
of patients given Gleevec or the previous standard treatment, interferon alfa plus
cytarabine.
It happened while I was undergoing my first round
of a chemotherapy — a combination
of drugs called R - DHAP (rituximab, dexamethasone,
cytarabine and cisplatin).
High - Dose Chemotherapy Plus Transplant Not Recommended for DLBCL: The results
of an Italian study report that treatment
of high - risk diffuse large B - cell lymphoma (DLBCL) with abbreviated course
of rituximab dose - dense chemotherapy plus high - dose
cytarabine, mitoxantrone, and dexamethasone (R - MAD) plus carmustine, etoposide,
cytarabine, and melphalan (BEAM) plus autologous stem cell transplantation compared with a full course
of rituximab dose - dense chemotherapy did not improve overall survival.