Sentences with phrase «of cytidine»

This domain has been hypothesized to provide the enzymatic activity needed to convert C to U because it carries motifs characteristic of cytidine deaminases.

Not exact matches

Cytidines or uridines are added to C5 to generate chain lengths of 10 to 11 nucleotides, with longer products being generated at greatly reduced efficiency.

This cellular machinery translates its sequence of four kinds of nucleosides — adenosine, cytidine, uridine, and guanosine — into a protein.

As these cells rapidly proliferate, they also express high levels of an enzyme known as activation - induced cytidine deaminase (AID), which induces mutations in their DNA.

Particular cytidines in transcripts in chloroplasts and mitochondria of plant cells undergo modification to uridine by RNA editing (1).

Predominant role for activation - induced cytidine deaminase in generating IgG anti-nucleosomal antibodies of murine SLE.

Liu and coworkers developed last year's base editor by combining three proteins: a cytidine deaminase, a natural enzyme that converts C to uridine (U); a mutated Cas9 CRISPR enzyme that doesn't cut DNA but uses an associated guide RNA to target specific DNA sequences; and a protein that prevents reversion of U back to C.

Dr. Honjo is well known for his discovery of activation - induced cytidine deaminase that is essential for class switch recombination and somatic hypermutation.

Global demethylation requires activation - induced cytidine deaminase (AID)- mediated downregulation of UHRF1 protein, and abolishing demethylation leaves thousands of hypermethylated regions in the iPSC genome.

Crystal structure of an ADP - ribosylated protein with a cytidine deaminase - like fold, but unknown function (TM1506), from Thermotoga maritima at 2.70 A resolution.