Sentences with phrase «of cytidine deaminase»
This domain has been hypothesized to provide the enzymatic activity needed to convert C to U because it carries motifs characteristic of cytidine deaminases.
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As these cells rapidly proliferate, they also express high levels of an enzyme known as activation - induced cytidine deaminase (AID), which induces mutations in their DNA.
Predominant role for activation - induced cytidine deaminase in generating IgG anti-nucleosomal antibodies of murine SLE.
Liu and coworkers developed last year's base editor by combining three proteins: a cytidine deaminase, a natural enzyme that converts C to uridine (U); a mutated Cas9 CRISPR enzyme that doesn't cut DNA but uses an associated guide RNA to target specific DNA sequences; and a protein that prevents reversion of U back to C.
Dr. Honjo is well known for his discovery of activation - induced cytidine deaminase that is essential for class switch recombination and somatic hypermutation.
Global demethylation requires activation - induced cytidine deaminase (AID)- mediated downregulation of UHRF1 protein, and abolishing demethylation leaves thousands of hypermethylated regions in the iPSC genome.
Crystal structure of an ADP - ribosylated protein with a cytidine deaminase - like fold, but unknown function (TM1506), from Thermotoga maritima at 2.70 A resolution.