Sentences with phrase «of cytokine receptor»

The spatiotemporal organization of cytokine receptor signaling complexes is currently controversially debated.

Therefore, loss of the microRNA leads to overproduction of the cytokine receptor.

In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10

Not exact matches

Patients with depression exhibit the main features of an inflammatory response, including increased expression of cytokines and their receptors.

The TSRI scientists discovered the fundamental mechanism of the S1PR1 receptor, developed the chemical tools to synthesize both agonists and antagonists of the receptor, discovered the role of the receptor in the immune system's «cytokine storm» in pandemic influenza, and investigated the role of the receptor in type 1 diabetes.

Although SB 247464 doesn't work with human cells, the discovery will spur the pharmaceutical industry's search for protein - mimicking drugs, says Mark Goldsmith, who studies cytokine receptors at the University of California, San Francisco.

Current thinking regarding type III hypersensitivity is that immune cells within tissues sense the presence of these immune complexes (ICs) through specific receptor molecules and release inflammatory factors called cytokines that activate the endothelial cells lining adjacent blood vessels to promote the recruitment of neutrophils.

«If we can block the interaction of this cytokine with its receptor, we may be able to inhibit all of this cascade that we have defined and potentially develop a therapeutic for patients with inflammatory bowel disease, particularly ulcerative colitis,» Denning said.

Researchers led by David Wallach of the Weizmann Institute of Science in Rehovot looked more closely at a receptor called p55, which binds to a suicide - promoting cytokine called tumour necrosis factor (TNF).

And, indeed, previous research has shown that receptor tyrosine kinases, e.g. insulin receptors, and cytokine receptors, e.g. growth hormone receptors, exist in dimeric form even in the absence of ligands.

IL - 6 is a cytokine, a signal molecule that is produced and secreted both by immune cells and by tumor cells and binds specifically to a receptor (IL - 6R) that is found on the surfaces of many cell types.

In volunteers who received a BCG vaccination, she observed an increase in cytokine production (proteins that control immune cells) and in the number of receptors that play a role during the recognition of intruders.

The cytokine then binds to its receptor on the surface of the Müller cells and induces the release of additional inflammatory proteins that attract phagocytes to the damaged retina.

This block is caused by mutations of the gene encoding the γc cytokine receptor subunit of interleukin - 2, -4, -7, -9, and -15 receptors, which participates in the delivery of growth, survival, and differentiation signals to early lymphoid progenitors.

Rosenfeld's group went on to find that these cytokines trigger a relay team of molecules to alter the androgen receptor.

This causes the body's white blood cells to release type 1 interferon - alpha, a small cytokine protein that acts as a systemic alarm, triggering a cascade of additional immune activity as it binds with receptors in different tissues.

If interactions between IL - 15 and IL - 15Rα were to occur strictly as a secreted cytokine binding to a cell surface receptor, then similar exercise and muscle phenotypes would have been observed in both IL - 15Rα — KO mice and IL - 15 — KO mice, since ligand - receptor binding would have been interrupted in both of these mouse strains.

IL - 15 and IL - 15Rα interactions at the cell membrane can lead to recruitment of IL - 2Rβ and γc to form the heterotrimeric receptor, although IL - 15 signaling may not occur strictly as the result of a secreted cytokine binding to a cell surface receptor.

IL - 15 receptor α (IL - 15Rα) is a component of the heterotrimeric plasma membrane receptor for the pleiotropic cytokine IL - 15.

Yasushi Itoh and Ronald N. Germain report studies emphasizing the hierarchical organization of T cell receptor (TCR) signaling thresholds for induction of distinct cytokine responses, and demonstrate that this threshold phenomenon applies to individual cells.

Additionally, I work on the Th2 cytokines IL4 and IL13 and their receptors, and how these molecules can influence malignant progression of breast and colon cancers.

It is mediated by the inflammatory cytokines interleukin - 1 and tumour - necrosis factor, both of which are produced in high amounts following sustained activation of Toll - like receptor 4 by LPS.

The research on colitis models has focused particularly on the roles of cytokines such as IL - 10 and IL - 27, and members of the TNF super family and their various receptors.

The activation of Toll - like receptor 2, for example, triggers the release of proinflammatory cytokines by microglial cells (3).

Hsiou - Chi Liou and colleagues find that c - Rel, a lymphoid - specific member of the NF - kappaB / Rel family of transcriptional factors, is essential for B lymphocyte survival and cell cycle progression, [i] and that it is important for inducible cytokine and cytokine receptor expression and a key regulator of early activation and proliferation in T cells.

We show that synNotch receptors can be used to sculpt custom response programs in primary T cells: they can drive a la carte cytokine secretion profiles, biased T cell differentiation, and local delivery of non-native therapeutic payloads, such as antibodies, in response to antigen.

T cells exert their actions in two ways, either through direct cell - cell contact which involves transmembrane proteins present on both the T cell and interacting cell, or by the secretion of soluble proteins termed cytokines which have receptors on many lymphoid and some non-lymphoid cell types.

We have recently shown that blockade of the IL - 33 receptor ST2 leads to a decrease in the cytokine storm and enhanced survival in naive FHL2 mice (5).

We showed that inactivation of the ABL kinases in breast cancer cells resulted in decreased expression of genes in the JAK / STAT and cytokine / cytokine receptor pathway signatures, which may be due to decreased STAT5A mRNA expression and reduced STAT5 phosphorylation in ABL1 / ABL2 - depleted breast cancer cells.

It's been shown that PTP1B not only regulates insulin receptor signaling, but also regulates a number of other signaling cascades, including oncogenic signaling pathways such as EGF receptor signaling, IGF - 1 receptor signaling, as well as cytokine signaling such as interferon gamma, and interferon alpha signaling cascades.

Further, inactivation of the ABL kinases resulted in decreased expression of the genes in the Hippo, Janus kinase (JAK) / STAT, and cytokine / cytokine receptor pathway signatures (Fig. 6B).

The initial model for STAT signaling involves a specific cytokine binding to its cognate receptor and promoting the transphosphorylation of receptor associated tyrosine kinases from the Janus - activated kinase family (JAK).

Additional in vitro and in vivo studies are needed to determine the cause of the specificity of JAK2V617F for myeloid diseases, as second mutations, host modifiers, differential cytokine receptor expression, and other factors may influence the ultimate phenotype of hematopoietic progenitors that acquire the JAK2V617F mutation.

CD8 T cells specific for the noninflationary M45 epitope displayed a classic central memory phenotype, re-expressing the lymph node homing receptor CD62L and homeostatic cytokine receptors for IL - 7 and IL - 15, and produced low levels of IL - 2.

We've been particularly involved in understanding the effects of ethanol on hormone and cytokine receptor - dependent signal transduction.

Proinflammatory cytokines enhance estrogen - dependent expression of the multidrug transporter gene ABCG2 through estrogen receptor and NF -LCB- kappa -RCB- B cooperativity at adjacent response elements.

«Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll - like receptor - 4 and suppressor of cytokine signaling - 3.»

In the opposite situation, when a healthy immune system reacts to environmental factors through cytokine production, PRPs send signals via specific cell receptor sites to decrease the production of cytokines in order to balance the immune system.

Vitamin D receptors are ubiquitously expressed in T and B lymphocytes, natural killer cells, and monocytes (49, 50), and through the down - regulation of cytokines and other proinflammatory factors, vitamin D exerts profound antiinflammatory and antiproliferative actions, which would affect the turnover rate of leukocytes (1).

Citing again from the study previously mentioned titled Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll - Like Receptor - 4 and Suppressor of Cytokine Signaling - 3 «Thus, saturated fats may have a more profound role in the pathogenesis of postprandial inflammation, as they may also perpetuate inflammation through the increases in LPS and TLR - 4.»

Mama June is seeing someone new, but there's a big problem the guy just got out of prison after serving time for molesting one of June's In recent years, the cytokine receptors have come to demand the attention of more investigators than cytokines themselves, partly because of their

The expression of Toll - like receptors (TLRs), cytokine and chemokine responses were measured by real time PCR.