Sentences with phrase «of cytokine release»

After receiving the engineered cells, she experienced no fevers or other signs of cytokine release syndrome (CRS), a condition that has been observed in other patients undergoing CTL019.

«Although right now we are focusing on developing a cancer vaccine, in the future we could be able to manipulate which type of dendritic cells or other types of immune cells are recruited to the 3D scaffold by using different kinds of cytokines released from the MSRs,» said co-lead author Aileen Li, a graduate student pursuing her Ph.D. in bioengineering at Harvard SEAS.

Not exact matches

CAR - T treatments, including competing products from Novartis rivals Kite Pharma and Juno Therapeutics, come with the risk of potentially deadly side effects such as cytokine - release syndrome (CRS), in which a glut of T - cell - assisting cytokines can cause high fever, low blood pressure, and problems with lung oxygenation.

But while the technology itself is undeniably exciting, some companies, like Juno Therapeutics, have been struggling with the reality of dangerous side effects including cytokine release syndrome and brain swelling during trials.

About half of the patients in a Kymriah study got cytokine - release syndrome, a response to the reprogrammed cells running loose in the body.

(The FDA on Wednesday expanded the approval of Actemra, a rheumatoid - arthritis drug that can also treat cytokine - release syndrome.)

The release of inflammatory chemicals called «cytokines» (proteins secreted by specific cells involved in immunity and in inflammation) leads to biochemical reactions involving neurotransmitters.

And yet the intricacies of that science — the precise mechanisms through which adrenal glands release glucocorticoids and immune cells send out cytokines — don't tell us much about how best to help children in trouble.

Studies have long suggested that cytokines are released under conditions of psychological stress and that inflammation in the brain contributes to depression.

Outside of the brain, cytokines are released by immune cells fighting infections, and they can alter MHCI expression in a complicated feedback loop.

Current thinking regarding type III hypersensitivity is that immune cells within tissues sense the presence of these immune complexes (ICs) through specific receptor molecules and release inflammatory factors called cytokines that activate the endothelial cells lining adjacent blood vessels to promote the recruitment of neutrophils.

All 10 patients who received the CTL119 cells experienced mild cytokine release syndrome (CRS), a known potentially lethal type of toxicity, within a few days after receiving their infusions; however, none required treatment with tocilizumab, an immunosuppressant drug that blocks the effects of the inflammatory cytokine IL - 6.

In the absence of pain, morphine interferes with normal body function and is viewed as a pathogen, activating the brain's innate immune cells and causing the release of inflammatory chemicals such as cytokines.

In the brain, cytokines can disrupt the production and release of several important signaling chemicals, including serotonin, dopamine and glutamate, which help control emotion, appetite, sleep, learning and memory.

Old's insights suggested that Coley's toxin worked because it tricked the body into releasing a flood of cytokines by exposing the immune system to what seemed like an enormous bacterial attack.

One of the limitations of earlier compounds was their tendency to cause iNKT cells to release a rush of different cytokines.

In normal immune responses, a second type of helper cells, known as TH2, secrete another batch of cytokines, including one called interleukin - 4 (IL - 4) that turns off the cytokine release from TH1 cells.

It is also selective — encouraging iNKT cells to release a specific set of proteins known as Th1 cytokines — that stimulate anti-tumor immunity.

What's more, none of the patients experienced macrophage activate syndrome or cytokine release syndrome, an infusion reaction observed in other gene therapy trials characterized by fever, nausea, chills, hypotension or a rash.

The therapy was found to have an acceptable safety profile in all patients, with no clinical or laboratory signs of systemic cytokine release syndrome, a potentially serious toxicity that has been observed in other CAR trials.

Infections set off the release of cytokines, which are proteins that trigger inflammatory responses, including a rush of lymphocytes and the sacrifice of virus - compromised cells.

In the June issue of the journal Vaccine, Christopher Blyth at the University of Western Australia and colleagues found that Fluvax (but not other flu vaccines) triggered the release of high levels of cytokines in blood cells isolated from the children who had febrile seizures.

Four of the eight children experienced cytokine release syndrome.

The cytokine then binds to its receptor on the surface of the Müller cells and induces the release of additional inflammatory proteins that attract phagocytes to the damaged retina.

All six had cytokine release syndrome (CRS), from which they recovered after treatment with tocilizumab, an immunosuppressant drug that blocks the effects of the inflammatory cytokine IL - 6.

They can provide a range of beneficial effects, such as lowering inflammatory cytokines (chemicals released by the immune system that can cause problems in rheumatoid arthritis patients), reducing joint stiffness and pain, as well as lowering oxidative stress — the ability of the body to counteract or detoxify harmful chemicals.

This causes the body's white blood cells to release type 1 interferon - alpha, a small cytokine protein that acts as a systemic alarm, triggering a cascade of additional immune activity as it binds with receptors in different tissues.

They show that highly purified NS1 acts as a pathogen - associated molecular pattern (PAMP) that activates mouse macrophages and human peripheral blood mononuclear cells (PBMCs) in culture via TLR4, resulting in release of inflammatory cytokines — an effect that was blocked by either a TLR4 antagonist or an anti-TLR4 antibody.

Kasid said: «If the cells are targeted to the tumour, what additional effects would release of cytokines locally have on the tumour?»

Next the team zoomed in to look at what might be controlling the release of IL - 1RA and other cytokines.

«We found that mesenchymal stem cells, and especially gingival mesenchymal stem cells, release large amount of cytokines through an extracellular vesicle,» says Kou.

Activated macrophages release stereotypical profiles of cytokines and biologically active molecules such as NO, TNF - α, IL - 6, and IL - 1 (64).

When you get the flu, it's glial cells — which make up 85 % of the cells in the brain — that release pro-inflammatory cytokines to fight the virus.

Pinellia ternata lectin exerts a pro-inflammatory effect on macrophages by inducing the release of pro-inflammatory cytokines, the activation of the nuclear factor -?

The activation of Toll - like receptor 2, for example, triggers the release of proinflammatory cytokines by microglial cells (3).

Watkins» work with glia, for example, has indicated that long - term opioid therapy may have an effect similar to that of chronic inflammation, causing glial cells to release an excess of cytokines that actually reduce the drug's effectiveness in blocking pain.

Until now, however, achieving a similar feat in human cells has eluded scientists — partly because activating iNKT cells released different types of cytokines: some stimulated an immune response, while others inhibited it.

A possible mechanism behind the reported association could be the release of bacteria, bacterial products or pro-inflammatory cytokines from the periodontal lesions into the blood stream.

In a typical immune response, for instance, inflammatory proteins called cytokines will be released by immune cells at a site of inflammation and then other immune cells will use these cytokines like a trail of breadcrumbs to home in on the site of infection and destroy the pathogens that are causing it.

[14] In the gut, the release of cytokines and chemokines is important in initiating an adaptive immune response.

«The paper nicely shows that vaccination outcome is associated with the IL - 28B mutations and suggests that this happens because they influence the type of chemicals — called cytokines — that are released to orchestrate the immune response.

Acute stress leads to increased glucocorticoid release from the adrenal glands combined with sympathetic arousal, activation of the renin - angiotensin system, release of inflammatory cytokines, and changes of the immune system (247).

The team provided the most comprehensive data yet on cytokine release syndrome, neurological toxicities and infections after infusion of a CAR T - cell product, laying the groundwork for reducing the risk of the most severe toxic effects.

As they die, these cells release proteins, called cytokines, that cause inflammation and that attract healthy cellular targets promoting repeated rounds of infection and cell death.

Determine the mechanisms by which T cells promote antibody and complement interactions with endothelial cells resulting in activatation and release of cytokines.

In ZUMA - 1, 12 % of the patients had a grade 3 or higher cytokine release syndrome and that is essentially a patient requiring mechanical ventilation or needing treatment with a high - dose vasopressor.

Unfortunately, those patients may be unlikely to make it through the 17 days we need to manufacture the CAR T cells, and it is less likely that they will be able to tolerate the severe cytokine release syndrome or get through the other acute toxicities of therapy.

GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4 + T Cells and Is Immunosuppressive in Type 1 Diabetes.

Cytokine release syndrome occurs when many cytokines get released into the serum upon CAR T - cell injection; patients can get high fevers and sometimes hypertension, and occasionally there is a need for mechanical ventilation or administration of vasopressors, but that is rare.

This brain inflammation is caused by the release of cytokines, chemical messengers in the body that trigger an immune response, similar to a viral infection.