Sentences with phrase «of cytoskeletal»

Its growth cones serve as a model of cytoskeletal rearrangements.

Our research and comparative analysis will enable us to decipher the transition of cytoskeletal machinery from archaea to eukaryotes, thereby furthering our understanding of the foundations of eukaryote and multicellular life.

In order to determine how the functional roles of these cytoskeletal systems might have changed during the transition from archaea to eukaryotes, they will also be carrying out a comparative analysis of cell division in archaea and eukaryotes.

Although none of these organisms has yet been isolated, observed under the microscope nor cultured, these genome sequences provide us with an unprecedented opportunity to explore the origins of these cytoskeletal elements and promise to shed light on the evolutionary transition that led to the emergence of eukaryotes.

A mitotic GlcNAcylation / phosphorylation signaling complex alters the posttranslational state of the cytoskeletal protein vimentin.

Abnormal regulation of the cytoskeletal regulator Rho typifies macrophages of the major murine models of spontaneous autoimmunity.

Jan Brugués, Benoit Maugis, Jaume Casademunt, Pierre Nassoy, François Amblard, Pierre Sens Dynamical Organization of the Cytoskeletal Cortex Probed by Micropipette Aspiration.

Selective regulation of cytoskeletal tension and cell — matrix adhesion by RhoA and Src.

An InCytes from MBC Selection: A Mitotic GlcNAcylation / Phosphorylation Signaling Complex Alters the Posttranslational State of the Cytoskeletal Protein Vimentin.

Their observation provides a better understanding of cytoskeletal self - organization in general, which may in turn lead to better drug design and new materials that can mimic cellular behaviors.

«For several years, we have been studying myogenesis, a process by which muscles are formed during embryonic development,» says Jean - François Côté, PhD, Director of the Cytoskeletal Organization and Cell Migration research unit at the IRCM.

In particular, these characteristics determine how easily it can push against a cytoplasm's surrounding water and move through its ever - changing web of cytoskeletal protein structures.

The researchers used their SDC - PAINT method to visualize the network of cytoskeletal microtubule filaments (green) and their proximity with two additional proteins called TOM20 (red) and HSP60 (blue).

«Zika virus infections cause a drastic perturbation of the cytoskeletal network, re-organizing both intermediate filaments and microtubules into a cage - like structure that surrounds the replication machinery.»

The molecular biological regulation of this cytoskeletal - controlled process has not been completely analyzed yet.

Not exact matches

I found that culturing cardiac valve cells on synthetic hydrogels preserves their normal properties better than the traditional plastic plates do, and I discovered a signaling pathway connecting the stiffness of the supporting scaffold to the cells» cytoskeletal structure.

Under a microscope, a cell's cytoplasm can resemble a tiny underwater version of New York's Times Square: Thousands of proteins swarm through a cytoplasm's watery environment, coming together and breaking apart like a cytoskeletal flash mob.

Actin is a filamentous protein, which together with other cytoskeletal elements forms a dynamic network of filaments that provide both structural support, as well as critical functional capabilities, to the cell.

When pieces are cut or torn from hydras, the cytoskeletal pattern survives and becomes part of the new animal.

Hydras are much simpler than most of their cousins in the animal kingdom, but the basic pattern of aligned cytoskeletal fibers is common in many organs, including human muscles, heart, and guts.

One such compound was docetaxel, an anticancer drug that binds tubulin, and the other jasplakinolide, which specifically binds the cytoskeletal form of actin.

His group's paper in the Journal of Physics A: Mathematical and Theoretical describes a new theoretical approach to study the effect of intermolecular interactions on the dynamics of motor proteins that move along cytoskeletal filaments known as microtubules.

Dr. Simon Atkinson is a cell biologist with a basic research background in cytoskeletal proteins who is now Chair of Biology at the joint Indiana University - Purdue University graduate school in Indianapolis.

In the Pollard lab, he was involved in research that revealed how both healthy and cancerous cells moved by extending their cytoskeletal edges in a growing latticework of proteins.

The rapid onset of the freezing phenotype led to the hypothesis that Mcf1 may be acting on a pre-existing eukaryotic molecular switch governing actin cytoskeletal dynamics such as the rho GTPases.

Collectively, our results indicated that RASSF1 acts to restrict EMT and invasion by indirectly controlling YAP nuclear shuttling and activation through a RhoB - regulated cytoskeletal remodeling process, with potential implications to delay the progression of RASSF1 - hypermethylated lung tumors.

Proper transfer of V1 complexes or subunits from the membrane to the cytoplasm and back appears to require not only phosphorylation events, conformational changes in the V1VO holoenzyme, the V1 complex and the V1 subunit C, but also the temporary interaction with protein kinase A, cytoskeletal elements, the heterotrimeric protein complex RAVE and the glycolytic enzyme aldolase.

This synapse is composed of different Supra - Molecular Activation Clusters (SMACs) of receptors, cytoskeletal and signaling proteins.

Cytoskeletal rearrangements in human red blood cells induced by snake venoms: light microscopy of shapes and NMR studies of membrane function.

Initiation of chondrocyte self - assembly requires an intact cytoskeletal network.

In addition, breast cancer cells respond differently to S1P in terms of the regulation of actin cytoskeletal structures.

Detailed investigations demonstrated that the formation of stress fibers and cell - cell junctions created the force necessary for the condensation process, all mediated by MSCs through the actomyosin cytoskeletal axis.

Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c - Kit in small cell lung cancer cells.

The Wiskott - Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF - $ ąppa $ B (RelA) independently of its role in filamentous actin polymerization and actin cytoskeletal rearrangement.

Analysis of F - actin cytoskeletal dynamics, integrin activity, cell migration and other cell biology parameters

Future research focuses on lipid - protein and protein - protein interactions that are of more general importance for the function of membrane and cytoskeletal proteins, respectively.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

'» In 1991, in a Science paper, a team led by Lee and Trojanowski demonstrated that the cytoskeletal protein tau is a building block of neurofibrillary tangles, one of the characteristics of Alzheimer's disease.

To gain a better understanding of the evolutionary path by which these archaeal proteins gave rise to the eukaryotic cytoskeleton we have assembled a team of global experts in cytoskeletal biology and evolutionary cell biology.

I have worked in the area of microbiology and molecular biology for over 15 years during which time I focused on the study of cell division and cytoskeletal regulation in prokaryotes.

Assembly of the MreB - associated cytoskeletal ring of E.coli.

We aim to close this gap by implementing a novel assay to simultaneously assess the integrity of the axonal cytoskeletal structure (using electron microscopy) and a functional (physiological) correlate of healthy cytoskeletal structure, namely active axon transport, within individual RGC axons at an early stage of experimental glaucoma.

Specifically, the aims of recent projects were to determine whether axonal cytoskeletal disruption, transport abnormalities, and electrophysiological dysfunction occur prior to RGC death in experimental glaucoma (rodent and non-human primate models) and whether some of these phenomena are detectable by clinically - applicable means.

Jonathan Boulais and Jean - François Côté of the IRCM Cytoskeletal Organization and Cell Migration Research Unit, Jordan Pinder and Graham Dellaire of Dalhousie University, Daria Frank and Cyrus Khandanpour of the University Hospital of Essen, Josée Hébert and Elliot Drobetsky of the Centre de recherche de l'Hôpital Maisonneuve - Rosemont, and Stéphane Richard and Alexandre Orthwein of the Jewish General Hospital's Lady Davis Institute for Medical Research, also collaborated on the study.

With the discovery of Asgard» clade archaea, the homologs of key eukaryote cytoskeletal proteins have, for the first time, been identified in archaea.

Asymmetric RNA localisation can be achieved by different mechanisms, such as active transport of RNAs by motor proteins moving on cytoskeletal elements, local protection of RNAs from degradation, facilitated diffusion and trapping.

We also observed a large expansion of megakaryocyte colony - forming units derived from variant carriers and reduced proplatelet formation with abnormal cytoskeletal organization.

Subsequent comparison of ΔsptP S Typhi and S. Typhimurium strains demonstrated that, unlike SptP in S. Typhimurium, SptP in S Typhi was not involved in invasion or cytoskeletal recovery postinfection.

Many of the downregulated genes are smooth muscle cytoskeletal elements, including TCAP (titin - cap), TPN1 (tropomyosin), DMD (dystrophin), SMTN (smoothelin), TAGLN (transgelin), MYH11 (smooth muscle myosin heavy chain 11), and CNN1 (smooth muscle calponin 1).