Regulated spatial organization and sensitivity
of cytosolic protein oxidation in Caenorhabditis elegans
Not exact matches
«We identified the
cytosolic protein Vms1 as a key component
of a novel pathway termed mitoRQC that protects mitochondria from the toxic effects
of such aberrant
proteins,» explain the authors
of the study.
The
protein bound directly to repeat - containing nucleoporins and to a
cytosolic pool
of two nuclear messenger RNA (mRNA) binding
proteins, Nab2p and Nab4p.
A
cytosolic yeast karyopherin, Kap104p, was isolated and shown to function in the nuclear import
of a specific class
of proteins.
Delivery
of cytosolic components by autophagic adaptor
protein p62 endows autophagosomes with unique antimicrobial properties.
Cytosolic splice isoform
of Hsp70 nucleotide exchange factor Fes1 is required for the degradation
of misfolded
proteins in yeast.
It functions in the clearance
of misfolded
proteins and damaged organelles, as well as recycling
of cytosolic components during starvation to compensate for nutrient deprivation.
We hypothesized that certain lectins link glycosylated cargo
proteins and glycosphingolipids into molecular nanoenvironments from which endocytic pits are formed without the help
of the
cytosolic clathrin machinery (Figure 1).
Tsuji T, Matsuzaki J, Caballero OL, Jungbluth AA, Ritter G, Odunsi K, Old LJ, Gnjatic S. (2012) Heat shock
protein 90 - mediated peptide - selective presentation
of cytosolic tumor antigen for direct recognition
of tumors by CD4 + T cells.
Conversely, histamine N - methyltransferase, the other important enzyme inactivating histamine, is a
cytosolic protein that can convert histamine only in the intracellular space
of cells.