Sentences with phrase «of cytotoxic»

Yes, an evaluation of the cytotoxic and genotoxic activity of yerba maté on human white blood cells found it caused a significant increase in the rate of cell death.

Mice and human volunteers who underwent cycles of the Fasting Mimicking Diet had decreased numbers of myeloid cells, the inflammatory immune cells that become more numerous as we age, and increased numbers of cytotoxic T cells, which protect the body against viruses and cancer.

The main anti-tumour effect of ascorbic acid is due to its production of cytotoxic hydrogen peroxide [16].

All the special forces, they radio in the special forces are the cytotoxic or the natural killer kind of that cytotoxic first branch of the immune system, the TH1.

Mueller H, Kassack MU, Wiese M. Comparison of the usefulness of the MTT, ATP, and calcein assays to predict the potency of cytotoxic agents in various human cancer cell lines.

In mouse models of both tumors, treatment with the fusion protein significantly slowed tumor growth and extended survival, probably through the activity of cytotoxic CD8 T cells.

Mbitikon - Kobo FM, Bonneville M, Sekaly RP, Trautmann L. Ex vivo measurement of the cytotoxic capacity of human primary antigen - specific CD8 T cells.

This results in the accumulation of the cytotoxic drug in cells with disabled efflux mechanisms and reduces resistance.

: We conclude that treatment of triple negative breast cancers with growth hormone - releasing hormone antagonists reduces tumor growth and potentiates the effects of cytotoxic therapy by nullifying drug resistance.

This work demonstrated the central role of HLA - B * 27 and HLA - B * 57 in immune control of HIV infection, and of cytotoxic T lymphocyte (CTL) escape in HIV pathogenesis (Goulder et al, AIDS Res Hum Retr, 1996; Goulder et al, Nat Med, 1997).

A targeted approach will develop vaccines that can reverse these age - related changes in T - cell responses, particularly the functions of cytotoxic T lymphocytes.

«The observed increase in the ratio of cytotoxic CD4 T cells to CD4 helper T cells indicates that they are an important component of the protective immune response to viral infections and that their induction should be an important marker for successful vaccinations against certain viral diseases,» says postdoctoral researcher and first author Veena Patil, Ph.D. «But we really didn't know enough about their molecular profile and the mechanisms that drive their differentiation and maintenance.»

g defined serum - free conditions outlined in Ng, et al [7], which overall gave rise to a CD45 + CD56 + CD117 − CD94 + population of cytotoxic NK cells [8] expressing the CD4 construct and other surface markers in a similar manner to peripheral blood NK cells.

The targeted drug delivery appears to be a very promising strategy for controlling the biodistribution of the cytotoxic agent only on malignant tissues by linking it to tumor - targeting moiety.

Positive clones were then differentiated using defined serum - free conditions outlined in Ng, et al [7], which overall gave rise to a CD45 + CD56 + CD117 − CD94 + population of cytotoxic NK cells [8] expressing the CD4 construct and other surface markers in a similar manner to peripheral blood NK cells.

Role in suppression of cytotoxic T lymphocyte response and viral persistence.

Rasmusson I, Ringden O, Sundberg B, Le Blanc K. Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells.

A Marked Reduction in Priming of Cytotoxic CD8 + T Cells Mediated by Stress - Induced Glucocorticoids Involves Multiple Deficiencies in Cross-Presentation by Dendritic Cells.

We studied the mechanism of lymphocytic choriomeningitis virus (LCMV) persistence and the suppression of cytotoxic T lymphocyte (CTL) responses in BALB / c WEHI mice infected at birth with LCMV Armstrong strain.

However, this is the first organ that degenerates in adults and in addition to that the thymus gland is extremely sensitive to a number of cytotoxic factors, such as chemotherapy, the action of various toxins, unfavorable environment.

natural killer (NK) cells - a type of cytotoxic lymphocyte that constitute a major component of the innate immune system.

Accumulation of cytotoxic non-coding Alu repetitive RNAs in macular cells seems to underlie AMD pathology.

Hodi FS, Mihm MC, Soiffer RJ, Haluska FG, Butler M, Seiden MV, Davis T, Henry - Spires R, MacRae S, Willman A, Padera R, Jaklitsch MT, Shankar S, Chen TC, Korman A, Allison JP, Dranoff G. Biologic activity of cytotoxic T lymphocyte - associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients.

They compared the number of cytotoxic T cells — which help battle a virus by killing body cells that harbor it — in normal mice and animals missing IL - 33.

Besides expanding the ranks of cytotoxic T cells, IL - 33 seems to prime them for combat.

To initiate an oxygen - independent reaction in a PDT, the molecule applied has to be of cytotoxic nature.

Not exact matches

Approximately one year after successful treatment with cytotoxic chemotherapy and radiotherapy, patients with advanced Small Cell Lung Cancer (SCLC), which primarily affects heavy smokers, generally relapse with recurrence of tumours that are resistant to further chemotherapy.

«Myeloid - derived suppressor cells (MDSCs) produce reactive nitrogen radicals that alter the receptors on the surface of the tumour to hide it from cytotoxic lymphocytes that kill tumour cells.

The researchers demonstrate that the use of specific cytotoxic substances can also have a beneficial effect on the body's immune system.

No targeted therapy has been approved for noninflammatory and inflammatory triple - negative breast cancer tumors, and the standard of therapy for these tumors is a combination of conventional cytotoxic chemotherapeutic agents.

This is the first trial reporting successful transplant in dyskeratosis congenita (DC) patients without the use of any radiation or conventional cytotoxic chemotherapy beforehand.

DAP12 plays a critical role in activating the NK cells» cytotoxic pathways; therefore, lower levels of DAP12 in NK cells results in a reduced ability to target tumor cells.

«These new results are significant because they represent the discovery of a number of more potent variations of the natural product as cytotoxic agents against cancer cells,» Nicolaou said.

In particular, they found significant expansion of CD3 + CD8 + cytotoxic T - cells and CD3 + CD4 + helper T - cells in circulating blood, as well as increased CD4 + subsets of Th1, Th2, Th17 and Treg cells, indicating a pro-inflammatory response.

The researchers also analyzed specific immune cells called cytotoxic T cells isolated from the patients» blood and found increases in biomarkers indicative of immune activation.

They are designed to get around one of the ways that cancer protects itself from the immune system: tumors can activate the body's natural protective response from autoimmunity, called a checkpoint, and thereby thwart cytotoxic T cells.

Known as a checkpoint inhibitor, tremelimumab is an investigational monoclonal antibody that «cuts the brakes» of the immune system by targeting cytotoxic T - lymphocyte antigen 4 (CTLA - 4), a protein that can switch off a patient's immune response.

«We studied human T cells, isolated from blood donors of all ages, to compare mature cytotoxic T cells with naive ones,» said Philip Ansumana Hull, graduate student in Ott's lab and one of the first authors of the study.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

B cells, cytotoxic T cells, and helper T cells boost their use of glucose and increase their reliance on the glycolysis pathway to digest the sugar.

They induce CD4 + helper T cell responses, which in turn activate cytotoxic T cells and direct them to recognize and fight specific types of cancer.

Before the vaccination, only 4 % of the participants» cytotoxic T lymphocytes (a type of white blood cell that helps control infections) specifically targeted these conserved proteins; after vaccination, that jumped to 67 %.

This trial involved patients who had not previously been exposed to cytotoxic chemotherapy, but its conclusions were similar to those of the first.

Thus, the molecule's observed «effect» on cell growth is nothing more than the well - known cytotoxic effect of alcohol.

«We had some indication that rapamycin would enhance the cytotoxic T cell effect, from previous experiments in both animals and humans showing that the drug produced modest effects by itself,» says Maria Castro, Ph.D., senior author of the new paper.

The Arf6 pathway may also boost the drug resistance of breast cancer cells, and Hashimoto et al. found that inhibiting Rab11b, or a component of the Arf6 pathway called EPB41L5, increased the sensitivity of MDA - MB - 231 cells to two different cytotoxic compounds.

In the sensitive tumor models, the ability of anti — cytotoxic T lymphocyte — associated protein 4 or anti — programmed cell death 1 therapy to increase vessel perfusion strongly correlated with its antitumor efficacy.

Ipilimumab targets a protein called cytotoxic T lymphocytic antigen - 4 (CTLA - 4) that is found on a type of immune cell called a T cell.

Uenaka A, Ono T, Akisawa T, Wada H, Yasuda T, Nakayama E. Identification of a unique antigen peptide pRL1 on BALB / c RL male 1 leukemia recognized by cytotoxic T lymphocytes and its relation to the Akt oncogene.

Depletion of neutrophils blocks the recruitment of antigen non-specific cells into the liver without affecting the antiviral activity of hepatitis B virus - specific cytotoxic T lymphocytes.