Sentences with phrase «of damage accumulation»

That call was made based on the evidence arising from many fields of medical research, and from a considered perspective of aging as a process of damage accumulation, one that can be most effectively treated by repair of that damage.

Not exact matches

One study published in the American Academy of Optometry's Optometry & Vision Science journal found that using goji berry daily as a dietary supplementation for 90 days increases plasma zeaxanthin and antioxidant levels significantly, which protect eyes from hypopigmentation and accumulation of oxidative stress compounds that can damage the macula.

One of the primary causes of cancer is the accumulation of DNA damage by free radicals.

The governor said that a total of 14 fatalities and six injuries were attributed to the storm, and more than 370 roofs were damaged and 38 structures completely destroyed due to the weight of the considerable snow accumulation.

In this study, partial reprogramming of cells in vitro reduced DNA damage accumulation and restored nuclear structure.

«New method to reduce accumulation of damaging Huntington's disease protein.»

The newly identified gene affects accumulation of amyloid - beta, a protein believed to be one of the main causes of the damage that underpins this brain disease in humans.

Oxidative stress is damage to the body caused by an accumulation of unstable molecules called free radicals.

Scientists have associated the accumulation of these clusters with tissue damage that leaves sponge - like holes in the brain.

The finding identifies how vulnerable cell groups react and respond differently to the accumulation of mitochondrial DNA damage seen in the disease, highlighting the need for cell - specific treatments.

The accumulation of these clusters has been associated with tissue damage that leaves sponge - like holes in the brain.

JA is produced immediately after something damages the plant tissue, and its accumulation usually leads to the creation of the compounds the insects find so distasteful.

These proteasomes usually rapidly stop functioning, leading to the accumulation of damaged proteins that further impair cell function, contributing to the vicious cycle that leads to cell death.

In aging, this gene expression presumably occurs to compensate for the accumulation of protein damages; during diapause, the same genes may be activated to prepare the whole embryo to catch up with the interrupted development and be ready to hatch as the rainy season starts.

Results show that one night of partial sleep deprivation activates gene expression patterns in peripheral blood mononuclear cells (PBMCs) consistent with increasing accumulation of damage that initiates cell cycle arrest and increases susceptibility to senescence.

To understand how this accumulation occurs in response to DNA damage, the scientists considered the role of CDK, or cyclin - dependent kinases.

Prof. Umeda found that inhibiting CDKs even with the absence of DNA damage would cause the Rep - MYB3R accumulation seen with DNA damage and stall the cell cycle before the M phase transition.

There is a great post at the Council on Foreign Relations blog where by Michael Levi boils down global climate change in to two overarching unknowns: (1) extent of damage by an accumulation of greenhouse gases, and (2) an uncertainty around which policies, or set of policies, will succeed in reducing emissions.

Within minutes, accumulation of bacteria interferes with repair of the tissue damage — and these results are the earliest indication showing H. pylori causing disease.

«How nerve cells are damaged by accumulation of abnormal proteins.»

Fatty liver disease results from excess accumulation of fat in the liver (hepatic steatosis), leading to inflammation and damage to the liver.

Protein aggregates that form after a cell is exposed to high, non-lethal temperatures appear to be part of an organized response to stress, and not the accumulation of damaged proteins en route to destruction.

Furthermore, impaired subthalamic activity was caused by anomalous receptor signaling, leading to defective energy metabolism and accumulation of damaging oxidants.

The cause of β cell damage in T2D is currently unknown, but compelling evidence implicates the formation and accumulation of IAPP misfolded aggregates in the pancreas (Hull et al., 2004; Haataja et al., 2008; Jurgens et al., 2011; Mukherjee et al., 2015), in a manner similar to the way protein aggregates have been shown to be causative agents in a variety of chronic and progressive PMDs (Soto, 2003).

On the other hand, if the stressful conditions prevail, accumulation of the damaged symbiotic zooxanthellae may not maintain the expulsion, which will gradually accumulate in coral tissues.

But in obesity, accumulation of lipids can cause fatty liver, resulting in cellular damage to the organ.

This response may be an adaptive strategy to moderate stress to ensure survival, but the accumulation of damaged Symbiodinium, which causes subsequent coral deterioration, may occur when this response can not cope with the magnitude or duration of environmental stress, and this might be a possible mechanism underlying coral bleaching during prolonged moderate thermal stress.

However, under thermal stress, the accumulation of damaged cells may exceed the increased rate of expulsion of digested zooxanthella.

These researchers consider that this loss of zooxanthellae and the accumulation of damaged cells results in coral bleaching.

Other genetic diseases include Tay - Sachs disease (damage to the gene for the enzyme hexosaminidase A leads to an accumulation of a chemical in the brain that destroys it), sickle cell anemia (improper coding of the gene that produces hemoglobin), hemophilia (lack of a gene for a blood - clotting factor) and muscular dystrophy (caused by a defective gene on the X chromosome).

Long - lived cells such as cardiomyocytes, retinal pigmented epithelial cells and neurons are particularly dependent of the efficient function of their lysosomes to prevent the accumulation of damaged macromolecules over their extended lifetimes.

The latter triggers a vicious cycle of persistent DDR and pro-inflammatory signals leading to chronic inflammation, tissue malfunction and degeneration with old age; in DNA repair - deficient patients, the rapid accumulation of DNA damage (in view of the DNA repair defect) would trigger the untimely activation of DDR signaling leading to the early manifestation of age - related pathology that is associated with chronic inflammation.

Since aging is exactly an accumulation of damage and the consequences of that damage, repair of the damage is the basis for rejuvenation, the reversal and prevention of degenerative aging and all age - related disease.

Moreover, some scientists suggest, that the damage of the DNA and the corresponding with it «wrong proteins» is a main factor for the accumulation of «all the cellular gunk», and they suppose, that even after the removal of the «gunc», it will accumulate again if the DNA remains damaged.

AD, PD, and other diseases and functional deficits of degenerative aging processes emerge from the ongoing and often mutually - reinforcing accumulation of multiple forms of cellular and molecular damage.

Despite the efficiency of DNA repair mechanisms, some DNA damage is left unrepaired leading to the gradual accumulation of DNA lesions in cells.

Reduction of the DNA repair factor led to an accumulation of DNA damage and to neuronal shrinkage.

In addition, the loss of Ripk2 has been demonstrated to result in the inability of cells to carry out mitophagy, leading to enhanced mitochondrial production of superoxide / reactive oxygen species and accumulation of damaged mitochondria that will trigger a caspase 1 — dependent inflammasome activation (Lupfer et al., 2014).

Age - induced accumulation of nuclear DNA damage, decline in mitochondrial function and alterations in gene expression have been thought to contribute to aging.

September 10, 2015 Protein aggregation after heat shock is an organized, reversible cellular response Protein aggregates that form after a cell is exposed to high, non-lethal temperatures appear to be part of an organized response to stress, and not the accumulation of damaged proteins en route to destruction.

Aging is characterized by an accumulation of molecular damage, decreased stress responses, and a reduced stem cell function, regeneration and organ maintenance.

One reason for this decline is thought to be the inevitable accumulation of misfolded and damaged proteins with time accompanied by the collapse in the cells» protective protein quality control mechanisms to deal with damaged proteins and restore homeostasis.

On the one hand, autophagy functions as a tumor suppressor mechanism by preventing the accumulation of damaged organelles and aggregated proteins.

It's the accumulation of damage and corrosion.

«In dermatology, the appearance of hyperpigmented spots — especially in chronic sun - damaged skin — is linked to a high lifetime accumulation of sunlight,» study author Christoph Schwab, MD, wrote in an email to Health.

The functional disruption leads to oxidative stress inside the cell; an accumulation of highly reactive oxygen compounds takes place and a large number of the cell's molecules are damaged.

Many of the studies which demonstrate the effectiveness of ice baths in reducing inflammation and accumulation of white blood cells (the guys responsible for destroying damaged tissue and creating signals for re-growth) measure this response over a very short time frame - for hours or a couple of days at best.

A diet high in saturated and trans fats and low in antioxidants can damage blood vessel walls to cause an immune response related to inflammation and the development of cardiovascular ailments.8, 9,10 Low - grade inflammation in older individuals has been shown to contribute to fat accumulation, insulin resistance, and inflammatory - related diseases.11

In our pharmacological class, we discovered aging due to oxidative damage, number of cell divisons, waste accumulation theory, teleomer lengths, effects due to circadian clock etc..

These are caused by damage to nerves (due to the accumulation of homocysteine and methylmalonic acid) and low neurotransmitter levels (because of the impaired synthesis of methionine, a precursor of many neurotransmitters).