Sentences with phrase «of damaged heart tissue»

Srivastava, director of the Gladstone Institute of Cardiovascular Disease, was selected for his innovative cardiology research on the regeneration of damaged heart tissue.

For many years, scientists worldwide have been searching for ways to stimulate the regeneration of damaged heart tissue.

MRI measured the mass of damaged heart tissue in all patients.

On average the transplanted stem cells regenerated 40 percent of the damaged heart tissue, said Dr. Michael Laflamme, UW assistant professor of pathology, whose team was principally responsible for generating the replacement heart muscle cells.

Not exact matches

It creates a biological response, Murthy says, that leads to chronic inflammation, damaged tissue and blood vessels, and an increased risk of heart disease, arthritis and diabetes.

But the No. 1 cause of death in people who are starving is heart failure due to extreme tissue and organ damage.

After a week of growth, they transplanted the patches of heart tissue into the damaged hearts of another set of rats.

Of those who survive, half are left with brain damage, which occurs when the heart starts beating again and a sudden rush of blood into oxygen - starved tissues triggers an avalanche of treacherous biochemical reactionOf those who survive, half are left with brain damage, which occurs when the heart starts beating again and a sudden rush of blood into oxygen - starved tissues triggers an avalanche of treacherous biochemical reactionof blood into oxygen - starved tissues triggers an avalanche of treacherous biochemical reactionof treacherous biochemical reactions.

«Diseased, damaged hearts with a lot of scar tissue don't contract and relax at the same time throughout the atrium because it is more difficult to rhythmically contract the thicker, tougher damaged tissue.»

The goal of stem cell therapy is to replace the damaged tissue with new heart cells and restore the failing heart to normal function.

The resulting lack of adequate blood flow can damage heart muscle and other tissues by depriving them of oxygen.

In the days after a heart attack, surviving patients and their loved ones can breathe a sigh of relief that the immediate danger is over — but the scar tissue that forms during the long healing process can inflict lasting damage.

Now, with new kinds of technologies that are coming up, new types of tissue engineering and, you know, some of the hopes that people have for stem cells and [the] like, it may be interesting to see if there are other ways, alternatives to dealing with really badly damaged hearts that would involve growing a new heart or replacing or repairing the damage d to a badly damaged heart that might make artificial hearts less important in the somewhat more distant future.

«It is our hope that Dr. Yin's research will lead to additional potential therapeutic agents like ZF143 to reactivate mechanisms for the repair and regeneration of damaged heart muscle tissue in humans.»

Yin's recent work is a continuation of earlier work identifying an experimental drug, ZF143, that accelerates the rate of tissue repair in damaged heart and limb tissue.

«A high - resolution ultrasound revealed harmonized pumping where iPS cells were introduced to the previously damaged heart tissue,» says Satsuki Yamada, M.D., Ph.D., first author of the study.

In the United States, about 720,000 residents experience a heart attack annually, which means that hundreds of thousands of heart patients are living with the disabling complications of heart disease who could benefit from therapies to repair and regenerate damaged heart tissue.

Normally, the inflammatory response to tissue damage after infarction — death of muscle tissue in a heart attack — has two stages.

Any tissue (not just skin) that is chronically inflamed because of the persistent presence of pathogens, toxins or genetic damage helps to spur illness, from heart disease to cancer.

Exploiting that power, researchers are now using microRNAs to convert the scar tissue of damaged hearts into healthy muscle cells, opening the door for a better therapy after heart attacks and heart failure.

There is a lot of work still to do, and many potential pitfalls before it could be applied to human patients, but in principle almost any illness caused by damaged or ageing tissue — heart disease, diabetes, Alzheimer's and dozens of others — could be fixed this way.

Researchers from the UNC School of Medicine have discovered that cells called fibroblasts, which normally give rise to scar tissue after a heart attack, can be turned into endothelial cells, which generate blood vessels to supply oxygen and nutrients to the injured regions of the heart, thus greatly reducing the damage done following heart attack.

The result — the second such finding in the past year — suggests that similar cells from human testicles might have similar powers, paving the way to creating replacement tissue for men who have suffered damage from heart attacks or other injuries and avoiding some of the controversy surrounding embryonic stem cells (ESC).

The spleen, which is 4 inches long and sits in the upper abdomen, acts as a reservoir of immune cells that speed to the site of heart injury after a heart attack to begin clearance of damaged tissue.

But the process, which is often set in motion by cells of the immune system, can also occur whenever tissue is damaged — even in the absence of a pathogenic organism — as, for example, when you stub your toe or, more seriously, suffer a heart attack.

The potential of iPS cells to help treat everything from damaged heart tissue to Parkinson's disease, has prompted intensive research that has looked into the use of skin fibroblast cells as an alternative to controversial embryonic stem cells.

When a person suffers a heart attack, scar tissue forms over the damaged areas of the heart, reducing the organ's...

Yin noted that with a better understanding of the genetic underpinnings that lead to tissue regeneration, he and his team may be able to develop new drug candidates that control the activity of the genetic circuits and repair damaged hearts.

Yin's work builds on earlier work identifying an experimental drug called ZF143 that hastens the rate of tissue repair in damaged heart and limb tissue.

Scientists at the Bar Harbor - based MDI Biological Laboratory have been awarded a patent — the first for the lab — for MSI - 1436, a potential new heart disease drug that stimulates the repair and regeneration of heart tissue damaged by injuries and heart attacks.

Friedreich's ataxiais an inherited disease that causes progressive damage to the nervous system, resulting in symptoms ranging from gait disturbance to speech problems; it can also lead to heart disease and diabetes.The ataxia of Friedreich's ataxia results from the degeneration of nerve tissue in the spinal cord, in particular sensory neurons essential (through connections with the cerebellum) for directing muscle movement of the arms and legs.

By stimulating the growth of new blood vessels, promoting anti-inflammatory effects, recruiting cells toward tissue regeneration and inhibiting further cell death, adult stem cells can restore some function to damaged or diseased heart muscle.

5/15/2008 New Role Found for a Cardiac Progenitor Population In a discovery that could one day lead to an understanding of how to regenerate damaged heart tissue, researchers at the University of California, San Diego have found that parent cells involved in embryonic development of the epicardium — the cell l...

One of the most serious classifications of this disease is known as diffuse scleroderma wherein the «sclerosis» (hardening of the tissue) occurs in the internal systems of the body, causing damage and widespread scarring to the skin as well as to various internal organs such as the lungs, kidneys, heart and gastrointestinal organs.

Okyanos cardiac cell therapy targets the restoration of blood flow to the heart and repairs damaged heart tissue caused by heart attack or ischemic and non-ischemic heart disease.

The U.S. Patent and Trademark Office has announced that it will grant a patent to MDI Biological Laboratory scientists Voot P. Yin, Ph.D., and Kevin Strange, Ph.D., and their collaborator Michael Zasloff, M.D., Ph.D., for use of the small molecule MSI - 1436 to stimulate the repair and regeneration of heart tissue damaged by injuries such as a heart attack.

Cardiac cell therapy helps restore blood flow and repair damaged heart tissue without the risk of rejection.

«The damage from a heart attack is typically permanent because heart - muscle cells — deprived of oxygen during the attack — die and scar tissue forms,» said Dr. Srivastava, who directs cardiovascular and stem cell research at Gladstone, an independent and nonprofit biomedical - research institution.

Re-introducing your own stem cells into an injured area of the body — be it a joint, damaged heart or other tissue — can stimulate new blood flow in these areas while reducing inflammation.

If the affected heart muscle is damaged it can heal, but it may not be able to pump blood like it used to because of scar tissue.

This paradigm of harnessing cells in nearby areas of damage to replenish lost tissue is not just applicable to the heart; it may be useful in many other organs in the body that have support cells like fibroblasts.

CINCINNATI - Scientists used an experimental targeted molecular therapy to block a matrix - forming protein in heart cells damaged by heart attack, reducing levels of scarred muscle tissue and saving mouse models from heart failure.

By studying them, we are beginning to gain insight into human disease — to understand why organs such as the heart can not repair themselves or why, as we age, the incidence of debilitating diseases such as cancer, heart disease and Alzheimer's increases so rapidly, and we are developing new therapies that will enhance our abilities to regenerate damaged tissues and prolong healthy lifespan.

The adult human heart is only half muscle; the other half is made of support cells called fibroblasts that help repair wounds and form scars around damaged tissue.

But now, scientists at the Gladstone Institutes have demonstrated that this damage need not be permanent — by finding a way to transform the class of cells that form human scar tissue into those that closely resemble beating heart cells.

The resulting ischemia (restriction in blood supply) and ensuing oxygen shortage, if left untreated for a sufficient period of time, can cause damage or death (infarction) of heart muscle tissue (myocardium).

Adults over 65 are at increased risk for complications from pneumonia, and serious cases that require hospitalization have been linked to long - term health issues like cardiovascular tissue damage and an increased risk of heart disease.

Ripe bananas contain a slightly higher concentration of antioxidant compounds than unripe bananas, says David L. Katz, M.D. Antioxidants are able to inhibit free radicals from damaging DNA and cellular tissue, and a diet rich in a variety of antioxidants may be instrumental in preventing cancer, heart disease, diabetes and neurodegenerative disorders like Alzheimer's disease.

Oxidative damage to the... blood vessels causes arterio - and atherosclerosis (hardening of the arterioles and arteries) leading to heart disease and stroke; brain causes Alzheimer's and Parkinson's disease; eyes causes cataracts and macular degeneration; skin causes wrinkles, sagging and «age spots»; connective tissue causes faulty collagen and elastin formation, possibly leading to tendonitis / osis, and other musculoskeletal complications and injuries; etc..

The compartments aren't able to expand as much as they're supposed to be able to under increased pressure and you get a ton of pressure within the muscles and as that happens, it compresses nerves and blood vessels and decreases blood flow which means that the tissues inside that compartment don't get enough oxygen rich blood and they are essentially oxygen starved and they become damage the same way that your heart, if oxygen starved, undergoes a heart attack and this can not be painful but can be damaging to the muscles.