In the development and growth phases or during regeneration, stem cells provide backup and can generate sizeable
amounts of daughter cells.
Prior to cell division, this DNA splits into two single strands, each bearing sequences of biochemical bases that form templates for the
genomes of the daughter cells.
This complex biological machine gathers the chromosomes together and sorts them at the time of cell division, then sends them to the opposite poles
of the daughter cells in a process called chromosome segregation.
When they divide, they produce two
types of daughter cells: some become new stem cells, while others differentiate to replace tissue or form new organs.
To facilitate these approaches, novel microfluidic platforms automating the separation
of daughter cells away from their mothers will be used.
Aggressive cancer treatment creates just such an environment, favoring those cells able to reproduce quickly, producing large
numbers of daughter cells, with a few evading extrinsic mortality to repopulate the tumor.
However, only the columella stem cell daughters die preferentially, and the
death of these daughter cells allows maintenance of a functional stem cell niche.
In organoids, the brain cells organize themselves — very similar to the process in the brain of an embryo: the stem cells divide; a
proportion of the daughter cells develops into nerve cells; these move to wherever they are needed.
A typical yeast cell replicates through
budding of a daughter cell and can undergo 20 - 30 such replication events before senescence.
A careful analysis allows us to track nuclei movements over time, to determine when cell divisions occur, to measure the
orientation of daughter cells in three dimensions and to generate the complete lineage of all cells (von Wangenheim et al. 2014; Rosquete et al. 2013; Lucas et al. 2013; Vermeer et al. 2014).
Stem cells can be cultured in the laboratory, but produce only two
types of daughter cells: neutrophils and macrophages.
In fact, the researchers showed that the synthesis of the capsule is controlled by the same mechanisms that regulate the cell cycle, and identified the protein that inhibits the production of the sugar capsule in one
of the daughter cells.
When a cell divides, it duplicates its chromosomes to make one set for
each of the daughter cells.
The transit amplifying cell undergoes multiple rounds of symmetrical divisions before
all of its daughter cells begin the process of differentiating into neurons.
When a cell divides, its DNA double helix unzips so that the genome can be copied, one for
each of the daughter cells.
Notch activity is antagonised by the cell fate determinant Numb, which asymmetrically partitions at mitosis and «switches off» Notch signalling in one
of the daughter cells (7).