Sentences with phrase «of deiodinases»

Although very minor amounts of selenium appear sufficient for adequate activity of deiodinases, thus limiting the impact of its potential deficiency on synthesis of thyroid hormones, selenium status appears to have an impact on the development of thyroid pathologies.

Due to a unique make - up of deiodinases in the pituitary, it will respond differently and often opposite to that of every other tissue in the body.

Because it is the activity of these deiodinases and transport of T4 and T3 into the cell that determines tissue and cellular thyroid levels and not serum thyroid levels, serum thyroid hormone levels may not necessarily predict tissue thyroid levels under a variety of physiologic conditions.

[Laura Sittig et al., «Strain - specific vulnerability to alcohol exposure in utero via hippocampal parent - of - origin expression of deiodinase - III»]

«DNA methylation is a key mechanism by which day length and melatonin levels exert seasonal control over the expression of the deiodinase enzyme known as dio3, and dio3 expression likely acts as a key step for the maintenance of reproductive competency during the breeding season,» said co-author Tyler Stevenson, senior lecturer at the Institute of Biological and Environmental Sciences at the University of Aberdeen in Scotland.

The activity of each type of deiodinase enzyme changes in response to differing physiologic conditions, and this local control of intracellular T4 and T3 levels results in different tissue levels of T4 and T3 under different conditions.

Not exact matches

For deiodinase type 1, 225 chemicals, or 12 % of those tested, showed potential for inhibiting the enzyme (Toxicol.

The researchers screened more than 1,800 chemicals using each of the three deiodinase enzymes.

With so many of the test chemicals flagged as potential endocrine disruptors — 495 potential TPO inhibitors, 404 potential NIS inhibitors, and 225 potential deiodinase inhibitors, among others — EPA may find that those tests will also take decades to complete.

To accurately assess thyroid function, it must be understood that deiodinase enzymes are essential control points of cellular thyroid activity that determine intracellular activation and deactivation of thyroid hormones.

The T3 hormone is known as the «metabolically active» hormone and is produced by the conversion of the «metabolically inactive» T4 hormone (by the deiodinase system).

Interrelationships among thyroxine, growth hormone, and the sympathetic nervous system in the regulation of 5 - iodothyronine deiodinase in rat brown adipose tissue.

Selenium makes up a component of enzymes, called thyroid hormone deiodinases, which help activate and inactivate thyroid hormones, which regulates your thyroid function.

A study by Cettour - Rose et al. published in American Journal of Physiology, Endocrinology and Metabolism demonstrated that physiologic reversal of leptin resistance restored deiodinase activity except in the presence of elevated reverse T3 (86).

Liver Problems: If the liver is sluggish than it will not be able to convert the normal 60 % of T4 - T3 by the 5» deiodinase enzymes.

One of the enzymes that's responsible for thyroid conversion, the 5 - deiodinase enzyme — you break it down 5 - deiodinase.

This is a big mistake, since many of the endocrine - disrupting chemicals we are exposed to are blockers of the 5 ′ - deiodinase enzyme that converts T4 to active T3.

«A wide variety of organochlorine compounds and pesticides have an effect on the thyroid hormones in plasma, tissues and deiodinase enzymes, which are in charge of stabilising the thyroid hormones in tissues.»