Sentences with phrase «of diabetic nephropathy»

He contributes to other large - scale clinical trials including SAVE (evaluating whether treatment of obstructive sleep apnoea with continuous positive airways pressure can reduce the incidence of serious CV events in patients with established CVD), and CREDENCE, a randomised, double - blind, placebo - controlled trial assessing whether canagliflozin can slow the progression of diabetic nephropathy in patients with type 2 diabetes.

Furthermore, sex - specific differences in gene polymorphism are suggested by one study showing that diabetic women carrying ACE D allele have a higher risk for development of diabetic nephropathy, which was not seen in diabetic men (Table 2)(331).

In an accompanying editorial, Kiran Chandrashekar, MD and Luis Juncos, MD (University of Mississippi) noted that there is a critical need to develop additional therapies to improve the treatment of diabetic nephropathy and that endothelin inhibitors hold considerable promise.

He has made important contributions to the fields of diabetic nephropathy, pregnancy - associated disease, renal vascular hypertension and transplantation.

In this prospective, open and non-randomized study, the effect of alpha - lipoic acid on the progression of endothelial cell damage and the course of diabetic nephropathy, as assessed by measurement of plasma thrombomodulin and urinary albumin concentration (UAC), was evaluated in 84 patients with diabetes mellitus over 18 months.

It is postulated that the significant decrease in plasma thrombomodulin and failure of UAC to increase observed in the alpha - lipoic acid treated group is due to antioxidative effects of alpha - lipoic acid, and if so that oxidative stress plays a central role in the pathogenesis of diabetic nephropathy.

Men show faster progression of diabetic nephropathy and more often undergo dialysis therapy (318).

In contrast, testosterone accelerates the development of nondiabetic chronic renal disease, and in streptozotocin - induced diabetic male rats, decreased testosterone levels and changes of sex hormone levels exacerbated the development of diabetic nephropathy, showing the importance of sex hormones in pathophysiologic mechanisms behind disease progression (334).

In patients with chronic kidney disease who are not on dialysis, ACEIs and ARBs slow the progression of diabetic nephropathy and reduce cardiovascular risk.

Paolo Fiorina, MD, PhD (Boston Children's Hospital / Harvard Medical School) and his colleagues have discovered that a receptor called B7 - 1 is expressed by kidney cells during the progression of diabetic nephropathy.

The results suggest that effective therapeutic agents could be developed to enhance the effects of GLP - 1R on the endothelium which may prevent glomerular endothelial dysfunction and slow the progression of diabetic nephropathy.