A 2014 meta - analysis
of dietary trials reached much the same conclusion.
Not exact matches
That's just one
of the reasons FloraGLO is trusted most by doctors — based on the results
of the National Disease and Therapeutic Index syndicated report among physicians who recommend a
dietary supplement with lutein for eye health between September 2009 and September 2010 — and is the brand being used in the National Eye Institute's AREDS 2
trial.
Dietary sugars and body weight: systematic review and meta - analyses
of randomised controlled
trials and cohort studies
One
of the biggest studies done recently on nutrition, from the Women's Health Initiative
Dietary Modification
Trial, showed no real benefits from a low - fat diet.
If soothing or feeding practices aren't reducing crying or irritability, your doctor may recommend a short - term
trial of dietary changes.
Screening, random assignment, and follow - up
of the study participants in the Swedish
dietary and exercise behavior - modification intervention
trial in lactating overweight and obese women.
In the randomized controlled
trial, 38 men with abdominal obesity followed a
dietary pattern high in either carbohydrates or fat,
of which about half was saturated.
In an effort to find out, Stephen P. Juraschek, M.D., Ph.D., research and clinical fellow in general internal medicine at the Johns Hopkins University School
of Medicine, and his colleagues used data from the DASH (
Dietary Approaches to Stop Hypertension) clinical
trial, a widely popular and often - cited study whose results were first published in 1997.
It typically takes many years to initiate such
trials because
of the stringent safety testing that must be done before testing in humans begins, but Reynolds said it may be possible to move faster as the therapy only involves modifying a patient's
dietary intake and supplementing with a medium - chain triglyceride oil, both
of which have no known side effects.
Although the analysis found pulses had little impact on «second meal food intake,» the amount
of food someone eats at his or her next meal, these findings support longer term clinical
trials that have shown a weight loss benefit
of dietary pulses.
A systematic review and meta - analysis
of all available clinical
trials found that people felt 31 per cent fuller after eating on average 160 grams
of dietary pulses compared with a control diet, according to senior author Dr. John Sievenpiper
of St. Michael's Hospital's Clinical Nutrition and Risk Factor Modification Centre.
However, as a physician, I strongly urge patients to wait for the results
of the clinical
trial and to discuss all
dietary and supplemental changes with their doctors.»
Previous research has largely focused on
dietary components and which diet would be best to lower the risk
of obesity and type 2 diabetes, but so far there is no clear evidence from epidemiological or clinical
trial data that a specific diet is optimal for long - term weight - loss or lowering the risk
of diabetes.
Results
of the randomized clinical
trial of the
dietary combination, conducted by researchers at the Johns Hopkins University School
of Medicine, were published in the Nov. 12 issue
of Journal
of the American College
of Cardiology.
Consider the Women's Health Initiative, the largest and longest randomized controlled clinical
trial of a
dietary intervention.
Overall, the investigators found that foods, nutrients,
dietary patterns or supplement use assessed before the start
of the clinical
trial had no measurable influence on the effectiveness
of a multivitamin on CVD risk in middle - aged and older men.
«In the absence
of such a
trial, results
of the PURE study argue against reduction
of dietary sodium to currently recommended levels as an isolated public health recommendation,» she said.
The article is entitled «A Randomized Crossover
Trial of Dietary Sodium Restriction in Stage 3 - 4 Chronic Kidney Disease.»
Other evidence (including some from our own groups) suggests that the main
dietary culprit for excess weight in society remains excess fat intake, not necessarily excess sugars, whilst
trial evidence suggests all forms
of diets work to lessen weight.
These unfavorable effects
of n - 6 LA shown in the SDHS are consistent with two other randomized controlled
trials, in which experimental
dietary conditions selectively increased n - 6 LA in the place
of SFAs by replacing animal fats and common margarines with corn oil.50 51 Together, these three
trials provide a rare opportunity to evaluate the specific effects
of increasing n - 6 LA without confounding from concurrent increases in n - 3 PUFAs.
CREST - E, the largest clinical
trial of the
dietary supplement creatine, has been terminated early because an early analysis
of the results to date showed there was no realistic chance it could show positive results.
«
Dietary calcium intake is not associated with risk of fracture, and there is no clinical trial evidence that increasing calcium intake from dietary sources prevents fractures,» the study authors
Dietary calcium intake is not associated with risk
of fracture, and there is no clinical
trial evidence that increasing calcium intake from
dietary sources prevents fractures,» the study authors
dietary sources prevents fractures,» the study authors write.
Most recently, the American Journal
of Clinical Nutrition published a meta - analysis
of randomized controlled
trials and concluded that the paleo diet is one
of the most effective
dietary strategies to reduce body weight and prevent the risk
of chronic disease.
Bray GA, Smith SR, de Jonge L, Xie H, Rood J, Martin CK, Most M, Brock C, Mancuso S, Redman LM: Effect
of dietary protein content on weight gain, energy expenditure, and body composition during overeating: a randomized controlled
trial.
Johnson GH, Fritsche K. Effect
of dietary linoleic acid on markers
of inflammation in healthy persons: a systematic review
of randomized controlled
trials.
Targeted alteration
of dietary n - 3 and n - 6 fatty acids for the treatment
of chronic headaches: A randomized
trial.
Effect
of dietary protein content on weight gain, energy expenditure, and body composition during overeating: A randomized controlled
trial.
The first was a 2010
trial in the American Journal
of Epidemiology that examined the effect
of lifestyle and
dietary factors on mortality in middle aged women.
Another conclusion they came to, «weekly ratings
of perceived hunger did not differ by diet group during the
trial, which suggests, as discussed by others (31, 32), that it is the protein content
of the diet and not the severity
of dietary carbohydrate restriction that affects perceived hunger,» mirrored my own experience.
27 Studies cited by the 2010 DGAC Report demonstrate varied metabolic responses to lowered
dietary saturated fat, with certain subpopulations exhibiting adverse rather than improved health outcomes.3 Two recent comprehensive meta - analyses indicate that saturated fat is not linked to heart disease.28, 29 In fact, in a definitive review
of forty - eight clinical
trials, with over sixty - five thousand participants, the reduction or modification
of dietary fat had no effect on mortality, cardiovascular mortality, heart attacks, stroke, cancer, or diabetes.30 Yet, avoiding saturated fat remains a cornerstone
of national
dietary guidance.
The Canadian
Trial of Carbohydrates in Diabetes (CCD), a 1 - y controlled trial of low - glycemic - index dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C - reactive pr
Trial of Carbohydrates in Diabetes (CCD), a 1 - y controlled
trial of low - glycemic - index dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C - reactive pr
trial of low - glycemic - index
dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C - reactive protein
You can easily find large randomized controlled
trials demonstrating the importance
of dietary fiber on PubMed, as well.
Cook NR, «Long term effect
of dietary sodium reduction on cardiovascular disease outcomes: observational follow - up
of the
trials of hypertension prevention.
A systematic review
of all the
dietary trials showed that much
of the benefits
of a low carbohydrate approach faded by 1 year.In the follow up to the DIRECT study, it was found that by 12 months, weight had started to regain in all patients, including the low carbohydrate group.
The DRI for sodium, the foundation publication for our current recommendations for salt consumption, clearly state at the outset that «Because
of insufficient data from dose - response
trials, an Estimated Average Requirement (EAR) could not be established, and thus a Recommended
Dietary Allowance could not be derived.
«In summary, randomized controlled
trials that lowered intake
of dietary saturated fat and replaced it with polyunsaturated vegetable oil reduced CVD by?
Some important studies include: • Beneficial effects
of a high carbohydrate, high fiber diet on hyperglycemic diabetic men (1976) • Response
of non-insulin-dependent diabetic patients to an intensive program
of diet and exercise (1982) • Diet and exercise in the treatment
of NIDDM: The need for early emphasis (1994) • Toward improved management
of NIDDM: A randomized, controlled, pilot intervention using a low fat, vegetarian diet (1999) • The effects
of a low - fat, plant - based
dietary intervention on body weight, metabolism, and insulin sensitivity (2005) • A low - fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical
trial in individuals with type 2 diabetes (2006) • A low - fat vegan diet and a conventional diabetes diet in the treatment
of type 2 diabetes: a randomized, controlled, 74 - wk clinical
trial (2009) • Vegetarian diet improves insulin resistance and oxidative stress markers more than conventional diet in subjects with Type 2 diabetes (2011) • Glycemic and cardiovascular parameters improved in type 2 diabetes with the high nutrient density (HND) diet (2012)
All studies had to be listed in the Cochrane Central Register
of Controlled
Trials, and the
dietary interventions observed had to last at least 4 weeks.
Effect
of dietary protein content on weight gain, energy expenditure, and body composition during overeating: a randomized controlled
trial.
Other publications on cancer chemoprevention include Comprehensive review
of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical
trials, Chemopreventive effects
of natural
dietary compounds on cancer development, Organosulfur compounds in cancer chemoprevention, Cancer prevention by natural compounds, Cruciferous vegetables and cancer prevention, Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis, Cruciferous vegetables: cancer protective mechanisms
of glucosinolate hydrolysis products and selenium.
Long term experience 1981 High carbohydrate high in fibre diet in diabetes 2004
Dietary management
of diabetes mellitus in India and South East Asia 2014 Effect
of brown rice, white rice, and brown rice with legumes on blood glucose and insulin responses in overweight Asian Indians: a randomized controlled
trial
CAAT is proving effect in
trials and case studies, and oncologists are relatively willing to recommend the treatment as it is non-invasive, consisting
of predominantly
dietary changes, supplements and foodstuffs added, especially those that have an antioxidant effect; certain foods containing «harmful» amino acids reduced or removed from the regimen altogether.
1935 Effects
of the high carbohydrate - low calorie diet upon carbohydrate tolerance in diabetes mellitus 1955 Low - fat diet and therapeutic doses
of insulin in diabetes mellitus 1958 Effect
of rice diet on diabetes mellitus associated with vascular disease 1976 Beneficial effects
of a high carbohydrate, high fiber diet on hyperglycemic diabetic men 1977 Effect
of carbohydrate restriction and high carbohydrates diets on men with chemical diabetes 1979 High - carbohydrate, high - fiber diets for insulin - treated men with diabetes mellitus 1981 High carbohydrate high in fibre diet in diabetes 1982 Response
of non-insulin-dependent diabetic patients to an intensive program
of diet and exercise 1983 Long - term use
of a high - complex - carbohydrate, high - fiber, low - fat diet and exercise in the treatment
of NIDDM patients 1994 Diet and exercise in the treatment
of NIDDM: the need for early emphasis 1999 Toward improved management
of NIDDM: A randomized, controlled, pilot intervention using a lowfat, vegetarian diet 2005 The effects
of a low - fat, plant - based
dietary intervention on body weight, metabolism, and insulin sensitivity 2006 A low - fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical
trial in individuals with type 2 diabetes 2006 Effect
of short ‐ term Pritikin diet therapy on the metabolic syndrome 2009 A low - fat vegan diet and a conventional diabetes diet in the treatment
of type 2 diabetes: a randomized, controlled, 74 - wk clinical
trial
Again, data from randomized clinical
trials in children as young as 7 months
of age have demonstrated that these
dietary recommendations are safe and do not interfere with normal growth, development, and sexual maturation.44, 46,48
The new SMILES
trial was presented at the conference: the first randomized controlled diet depression study where ONE THIRD
of the
dietary intervention group saw improvements in their depression and anxiety symptoms by switching from processed / junk food to real food with no specific
dietary restrictions.
In a multicenter
trial in Spain, we randomly assigned participants who were at high cardiovascular risk, but with no cardiovascular disease at enrollment, to one
of three diets: a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce
dietary fat).
In humans, data collected from 38 different
trials of food consumption that used widely varying intakes
of protein, from 8 to 54 %
of energy, showed: «Percent
dietary protein was negatively associated with total energy intake (F = 6.9, P < 0.0001) irrespective
of whether carbohydrate (F = 0, P = 0.7) or fat (F = 0, P = 0.5) were the diluents
of protein.
PREDIMED, one
of the largest interventional
dietary trials, randomized more than 7,000 men and women at high cardiovascular risk into different diet groups and followed them for years.
The scientist in me hopes to see randomized, controlled
trials comparing the ability
of raw milk, pasteurized milk, UHT - treated milk, and milk - free diets to prevent and treat asthma, and comparing their effects with and without other nutritional treatments, such as the inclusion
of liver, bone broth, and other nutrient - dense foods, and
dietary or lifestyle interventions aimed at increasing the metabolic rate.
, Role
of Dietary Fats in Modulating Cardiometabolic Risk During Moderate Weight Gain: A Randomized Double - Blind Overfeeding
Trial (LIPOGAIN Study), 2014