Sentences with phrase «of different antibodies»

While at the Basel Institute for Immunology in Switzerland, he published a theory — first seen as heretical, then brilliant — that immune cells reshuffle their DNA to create millions of different antibodies from a small number of genes.

Retargeting of T cells to prostate stem cell antigen expressing tumor cells: comparison of different antibody formats.

a) To measure the overlap coefficient of different antibody binding sites, the signals were separated from background using a brightness criterion and made binary.

Novartis is typically looking at an extremely high number of different antibody sequences to identify the single one having the desired properties.

Not exact matches

Bia was able to test the rice syrup alongside two different ELISA methods, one using the R5 antibody and the other using the Skerritt antibody (a monoclonal antibody for gluten detection that can be used on a variety of cooked and uncooked foods).

That development is important because a T cell response will likely confer longer - term protection than current inoculations do and defend against a variety of flu strains (because T cells would be on the lookout for several different features of the flu virus whereas antibodies would be primarily focused on the shape of a specific strain).

In such patients, a phenomenon called «antibody - dependent enhancement» (ADE) takes place, during which antibodies that were generated during the first infection bind but do not destroy the slightly different newly infecting virus, but instead facilitate its infection of immune cells.

Some of the mice were inoculated with antibodies binding to different DENV serotypes, whereas a second group was naïve, that is, they did not have any anti-DENV antibodies.

By administering a complementary antibody, they blocked the function of two such immune checkpoints, whereby different types of endogenous T - cells were activated.

However, Schweitzer and her colleagues conducted a number of different tests on the T. rex sample, including testing for keratan sulfate using monoclonal antibodies, and compared their results to the same tests performed on known medullary tissue from ostrich and chicken bone.

In an effort to create a more precise diagnostic, the MIT team set out to find antibodies that would interact exclusively with NS1 protein produced by the Zika virus, as well as antibodies specific to NS1 from each of the four different strains of the Dengue virus.

In a study published in the May 29, 2014, edition of Molecular Ecology Resources, Duke researchers Peter Larsen, Ryan Campbell and Anne Yoder used high - throughput sequencing on sifaka blood samples to generate sequence data for more than 150,000 different sifaka antibodies — protective molecules that latch on to bacteria, viruses and other foreign invaders in the body and fight them off before they cause infection.

Data from in vivo mouse models indicate that delivery of the DMAb sequence for the influenza A-targeted monoclonal antibody protected against lethal doses of two very different, clinically relevant influenza A viruses.

Smider and colleagues took serum — blood with the cells removed, leaving antibodies behind — from four immunized cows and tested it against different types of HIV virus in a test tube.

An analysis of 41,302 blood samples taken from the entire study at different time points found that a child who had an intermediate antibody level and became infected again had a 7.64 times higher risk of being in the small group that developed DHS / DSS, researchers report today in Science.

«But when we looked at the different stages of breathing that have already been recognised, we found that this antibody - binding site was still hidden.

The theory that antibodies protective against one type of dengue can collude with a different type of the virus to make a second infection worse was proposed in the 1960s.

Second, the safety of designer proteins will have to be studied carefully, Crowe says, because they are markedly different than natural HA - binding antibodies.

Each antibody fits like a puzzle piece into an array of different proteins on the surfaces of invading pathogens; antibodies can also lock onto other antibodies — usually from a different species.

A small number of people infected with HIV produce antibodies with an amazing effect: Not only are the antibodies directed against the own virus strain, but also against different sub-types of HIV that circulate worldwide.

The idea is that the abundance of stem - focused antibodies — amplified from the two shots of vaccine — will come to the rescue during a natural infection from a virus that possesses a third, totally different head.

Antibodies derived from a type of immune cell found in unusually high numbers in HIV - infected individuals with chronically uncontrolled virus levels are less effective at neutralizing HIV than antibodies derived from a different type of immune cell more common in people without HIV, scientisAntibodies derived from a type of immune cell found in unusually high numbers in HIV - infected individuals with chronically uncontrolled virus levels are less effective at neutralizing HIV than antibodies derived from a different type of immune cell more common in people without HIV, scientisantibodies derived from a different type of immune cell more common in people without HIV, scientists report.

We know from HIV research that around one percent of people infected with HIV form antibodies that combat different virus strains.

Although some TIC - targeting antibodies are available, there is not a single universal antibody which covers all kinds of TICs from different tissues.

For one study in 2012 in Frontiers in Immunology, scientists from Canada injected these stem - recognizing antibodies into mice to see if the mice were shielded from a different strain of flu.

«Our results show how different factors boost the formation of antibodies that broadly combat different viral strains,» concludes Trkola.

For Alexandra Trkola, a professor of medical virology at UZH, this surprising discovery needs to be studied more closely: «First of all, we need to understand more precisely what significance and impact the genetic, geographical and socio - economic factors of people from different ethnicities have on the formation of these antibodies.»

Hookworm infections seem to provoke a mix of two different immune cells: type 1 T cells, which instruct other cells to directly attack pathogens, and type 2 T cells, which tell cells to produce antibodies.

The new «trivalent» vaccine induces antibodies against three different parts of the virus, including two components that normally help HSV2 evade immune attack.

Moreover, levels of Ebola fighting antibodies are not uniform in different people and some experts have even speculated that such transfusions could potentially do harm.

Once the peptides are captured, they flow along the strip and are exposed to several invisible test lines made of other antibodies specific to different tags attached to the peptides.

First, IgE antibodies from the patient's blood are isolated by interaction with magnetic beads that are coated with a different type of antibody.

The antibodies are tagged to reveal which proteins are expressed in each of the different tissues.

New research conducted by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, found that higher levels of antibody against a different flu surface protein — neuraminidase (NA)-- were the better predictor of protection against flu infection and its unpleasant side effects.

T cells are thought to be able to provide protection across different strains, says Teijaro, because the bits of influenza virus the T cells recognize do not mutate as much as the influenza surface proteins, the target of antibodies.

«We used two different antibodies — one of which has been in clinical trials for Alzheimer's — to neutralize the effects of amyloid - beta and showed that you're able to rescue changes in tau,» Young - Pearse said.

One point of contention is whether validation should be considered «pass / fail,» or whether it should yield a ranking to score different antibodies as better or worse than others for the same target and application.

The flu vaccine works by exposing the body to parts of inactivated flu from the three major different types of flu that infect humans, prompting the immune system to develop antibodies against these viruses.

«We found that antibodies called IgAs, which are commonly found on mucosal surfaces, can actually protect us from infections in two different ways,» adds the head of the study, who now works at The Scripps Research Institute in the USA.

Because different groups of people encounter different diseases — the European settlers had high exposure to smallpox, measles, and influenza thanks to close contact with livestock — they develop different antibodies.

However, high levels of a different type of envelope - binding antibody belonging to the IgA family were associated with a lack of protection against HIV infection.

For the new study, the team set out to do a proof - of - principle selection of antibodies that can bring about a different effect: protecting cells against an otherwise certain death.

Each B cell carries different rearrangements in its DNA, corresponding to the specificity and type of antibody it produces.

To investigate why checkpoint inhibitors so often stop working, Velculescu; Valsamo Anagnostou, M.D., Ph.D., instructor of oncology at the Johns Hopkins University School of Medicine; Kellie N. Smith, Ph.D., a cancer immunology research associate at the Johns Hopkins University School of Medicine; and their colleagues at the Bloomberg ~ Kimmel Institute for Cancer Immunotherapy studied tumors of four patients with non-small cell lung cancer and one patient with head and neck cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-CTLA4.

To see whether blocking CD47 could reverse plaque buildup, the group tested the experimental anticancer antibody drug in several different mouse models of cardiovascular disease.

BI-1206 showed remarkable success in mice in overcoming resistance to monoclonal antibodies like rituximab, currently used to treat different types of lymphoma and leukemia.

When low levels of antibodies from a previous dengue infection sense a new serotype is around, they weakly bind to the different serotype, lead it to cells with receptors for their constant regions, and the new serotype ultimately enters those cells.

Using this approach as a template, researchers could substitute other types of antibodies and vaccines to target different tumors.

Each patient had about 100 different autoantibodies in their blood, but since each patient had different autoantibodies, the 81 patients collectively had antibodies to thousands of different human proteins.

The researchers harvested satellite cells from both healthy and injured muscle tissue of young mice and from healthy tissue of old mice; extracted these cells» DNA with the histone coatings intact; and used tagged antibodies targeting the different kinds of marks to find which spots on those histones were flagged with either «stop» or «go» signals.